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PLA2G12A

  • Official Full Name

    phospholipase A2, group XIIA

  • Overview

    Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids;and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low;specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 (PubMed;11031251)).
  • Synonyms

    PLA2G12A; phospholipase A2, group XIIA; phospholipase A2, group XII , PLA2G12; group XIIA secretory phospholipase A2; EC 3.1.1.4; Group XIIA secretory phospholipase A2 precursor; GXII sPLA2; Phosphatidylcholine 2 acylhydrolase GXII; Phospholipase A2 group XIIA; PLA2G12; sPLA2-XII; group XII secreted phospholipase A2; group XIIA secreted phospholipase A2; phosphatidylcholine 2-acylhydrolase 12A; GXII; ROSSY;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • SUMO
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLA2G12A-1749H Recombinant Human PLA2G12A, GST-tagged E.coli GST 23-189aa
Human PLA2G12A-30734TH Recombinant Human PLA2G12A, His-tagged E.coli His
Human PLA2G12A-72H Recombinant Human Phospholipase A2, Group XIIA, His-tagged E.coli His
Human PLA2G12A-482HCL Recombinant Human PLA2G12A lysate HEK293 N/A
Human PLA2G12A-4792H Recombinant Human PLA2G12A protein, His&Myc-tagged E.coli His&Myc 23-189aa
Human PLA2G12A-2337H Recombinant Human PLA2G12A protein, His&Myc-tagged His&Myc 23-189aa
Human PLA2G12A-207HFL Recombinant Full Length Human PLA2G12A Protein, C-Flag-tagged Mammalian cells Flag
Human PLA2G12A-1881H Recombinant Human PLA2G12A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PLA2G12A-1692H-B Recombinant Human PLA2G12A Protein Pre-coupled Magnetic Beads HEK293
Human PLA2G12A-1709H Recombinant Human PLA2G12A Protein (23-185 aa), His-tagged Yeast His 23-185 aa
Human PLA2G12A-1692H Recombinant Human PLA2G12A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pla2g12a-712M Recombinant Mouse Phospholipase A2, Group XIIA E.coli N/A
Mouse PLA2G12A-12883M Recombinant Mouse PLA2G12A Protein Mammalian Cell His
Mouse Pla2g12a-8261M Recombinant Mouse Pla2g12a protein, His & T7-tagged E.coli His/T7 Gln26~Leu192 (Accession # Q9EPR2)
Mouse PLA2G12A-6794M Recombinant Mouse PLA2G12A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pla2g12a-4895M Recombinant Mouse Pla2g12a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pla2g12a-2338M Recombinant Mouse Pla2g12a protein, His&Myc-tagged Insect Cell His&Myc 26-192aa
Mouse PLA2G12A-6794M-B Recombinant Mouse PLA2G12A Protein Pre-coupled Magnetic Beads HEK293
Mouse PLA2G12A-4793M Recombinant Mouse PLA2G12A protein, His-SUMO-tagged E.coli His-SUMO 26-192aa
Mouse Pla2g12a-4794M Recombinant Mouse Pla2g12a protein, His&Myc-tagged E.coli His&Myc 26-192aa
Rhesus Macaque PLA2G12A-3452R Recombinant Rhesus monkey PLA2G12A Protein, His-tagged Mammalian Cell His
Rhesus Macaque PLA2G12A-3270R-B Recombinant Rhesus Macaque PLA2G12A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PLA2G12A-3270R Recombinant Rhesus Macaque PLA2G12A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PLA2G12A-5211Z Recombinant Zebrafish PLA2G12A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PLA2G12A Related Articles

PLA2G12A involved in several pathways and played different roles in them. We selected most pathways PLA2G12A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerophospholipid metabolismAGPAT3;PTDSS1A;PLA2G2F;GPD1C;DGKD;CHAT;AGPAT5;PHYKPL;AGPAT6
Ether lipid metabolismPLD1A;PPAP2C;PPAP2A;PLA2G4D;PLA2G2A;PLA2G2E;CHPT1;PLB1;PLA2G4B
Arachidonic acid metabolismPTGS2;LTC4S;CYP1A1;CYP2C8;ALOX12;CYP2C38;PLA2G4A;PLA2G4AA;GPX1A
Linoleic acid metabolismPLA2G4C;CYP2C50;PLA2G12B;CYP2C39;PLA2G12A;PLA2G4D;PLA2G2E;CYP2P9;CYP2C54
alpha-Linolenic acid metabolismPLA2G10;PLA2G6;PLA2G2F;PLA2G2D;FADS2;PLA2G2A;PLA2G12B;PLA2G2E;PLA2G4A
Metabolic pathwaysNDUFA8;BCMO1;ATP6V0A1A;PGM2;ALPI.1;CYP2P10;DHCR7;NMRK2;AGXT2L1
Ras signaling pathwayIKBKG;GNB1;RIN1;RAP1B;FGF1;PRKCB;PLCE1;RALBP1;KITLG
Vascular smooth muscle contractionPRKCG;MAPK1;MAPK3;PPP1R12B;PRKCH;PRKCE;CYP4A12A;ARAF;PLA2G4C
Pancreatic secretionRAB3D;PLCB4;PLA2G2D;ATP2B4;PLCB1;CLCA1;FXYD2;AMY2A4;RAP1A
Fat digestion and absorptionAGPAT2;DGAT1;APOB;MOGAT2;ACAT2;PLA2G12B;SCARB1;PPAP2C;PPAP2A

PLA2G12A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G12A itself. We selected most functions PLA2G12A had, and list some proteins which have the same functions with PLA2G12A. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingMMP20;MMP1A;DUOX2;SNED1;MYL12.2;ACTN1;SYT1;FKBP14;PCDH2G3
calcium-dependent phospholipase A2 activityPLA2G1B;PLA2G4F;PLA2G3;PLA2G2A;PLA2G12A;PLA2G4B;PLA2G4A;PLA2G5

PLA2G12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G12A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G12A.

DVL2; RB1; UMPS; YWHAG; RPS6; RPS15; MEF2C; TMEM37; UCK1; EPB41L3

Peuravuori, H; Kollanus, S; et al. Expression of group XIIA phospholipase A(2) in human digestive organs. APMIS 122:1171-1177(2014).
Ee, SM; Lo, YL; et al. Distribution of Secretory Phospholipase A2 XIIA in the Brain and its Role in Lipid Metabolism and Cognition. MOLECULAR NEUROBIOLOGY 50:60-75(2014).
  • Q&As
  • Reviews

Q&As (5)

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How does PLA2G12A contribute to cell signaling pathways? 12/15/2022

PLA2G12A-generated lipid mediators can act as signaling molecules, influencing various cellular processes and pathways.

Can PLA2G12A be a therapeutic target for cancer treatment? 03/22/2022

Investigations are underway to explore the role of PLA2G12A in cancer progression, with the goal of identifying therapeutic strategies to target this protein.

How does PLA2G12A contribute to inflammatory responses? 01/17/2019

PLA2G12A is involved in the generation of lipid mediators, such as eicosanoids, which play a role in inflammation and immune responses.

Can the measurement of PLA2G12A levels be used as a diagnostic marker? 01/16/2019

Studies suggest that alterations in PLA2G12A expression or activity may serve as potential diagnostic markers for certain diseases, although more research is needed.

Are there any ongoing clinical trials targeting PLA2G12A? 03/23/2016

Information on current clinical trials targeting PLA2G12A can be obtained from databases like ClinicalTrials.gov, indicating the evolving interest in its therapeutic potential.

Customer Reviews (3)

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Reviews
10/30/2017

    the manufacturer of the PLA2G12A protein plays a vital role in supporting my research endeavors.

    03/10/2017

      the manufacturer's commitment to ongoing innovation ensures that I have access to the most advanced and updated versions of the PLA2G12A protein.

      06/09/2016

        They proactively monitor scientific advancements and customer feedback to continually refine and improve the performance of the protein.

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