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PLA2G2E

  • Official Full Name

    phospholipase A2, group IIE

  • Overview

    Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.
  • Synonyms

    PLA2G2E; phospholipase A2, group IIE; group IIE secretory phospholipase A2; 2IIE; EC 3.1.1.4; GIIE sPLA2; Group IIE secretory phospholipase A2 precursor; Phosphatidylcholine 2 acylhydrolase GIIE; Phosphatidylcholine 2-acylhydrolase 2E; Phospholipase A2 group IIE; sPLA; sPLA2-IIE;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLA2G2E-69H Recombinant Human Phospholipase A2, Group IIE, His-tagged E.coli His
Mouse Pla2g2e -1196M Recombinant Mouse Pla2g2e protein, His-tagged HEK293 His Met 1-Cys 142
Mouse Pla2g2e-1196M Recombinant Mouse Pla2g2e, His-tagged Human Cell His
Mouse PLA2G2E-1874MCL Recombinant Mouse PLA2G2E cell lysate Human Cell N/A
Chicken PLA2G2E-4101C Recombinant Chicken PLA2G2E Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PLA2G2E Related Articles

PLA2G2E involved in several pathways and played different roles in them. We selected most pathways PLA2G2E participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G2E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerophospholipid metabolismTESCA;CHAT;PLA2G4D;ACHE;AGXT2L1;ADPRM;DGKA;PLD4;PLA2G12B
Ether lipid metabolismPLA2G2A;PLA2G12B;LPCAT2;PLD1;PAFAH1B2;PAFAH1B1A;PLD4;PLA2G5;PLA2G4A
Arachidonic acid metabolismALOX12E;GPX1;PTGS1;PTGESL;DPEP1;CYP2C8;PTGES;CYP2P9;LTC4S
Linoleic acid metabolismCYP2C8;CYP2C45;PLA2G2D;CYP2C50;CYP2P7;CYP2P6;PLA2G4F;PLA2G2A;PLA2G6
alpha-Linolenic acid metabolismPLA2G12A;PLA2G12B;FADS2;PLA2G2E;ACAA1;PLA2G5;PLA2G4D;PLA2G1B;PLA2G2D
Metabolic pathwaysB3GALNT1;ADH2-1;HSD11B1;AHCYL2;UGT1A2;GLULA;IPMK;NDUFA2;PLCH1
Ras signaling pathwayETS1;FOXO4;Fasl;GNB1;PLA2G4F;PDGFB;PLA2G6;MLLT4;PDGFD
Vascular smooth muscle contractionARHGEF12;CALM2B;PRKACAB;PPP1CAA;ADCY1A;PRKCA;GUCY1B3;CALM1;AVPR1B
Pancreatic secretionATP1B2;PNLIP;PLCB2;CELA2B;PLA2G2A;BST1;PLA2G1B;ATP2A1;RYR2
Fat digestion and absorptionFABP1;ACAT2;PLA2G2E;PNLIP;GOT2;CLPS;PLA2G2F;DGAT2;MOGAT2

PLA2G2E has several biochemical functions, for example, calcium ion binding, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G2E itself. We selected most functions PLA2G2E had, and list some proteins which have the same functions with PLA2G2E. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingSRR;TPT1;PCDH15A;DSG3;EFHA2;EGFL7;NOX5;THBS4;VSNL1
phospholipase A2 activityPLA2G4AA;PLA2G4D;PLA2G2F;PLA2G16;PLA2G6;PRDX6;PLB1;PLA2G2E;PLA2G1B

PLA2G2E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G2E here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G2E.

Yamaguchi, K; Chijiwa, T; et al. The Finding of a Group IIE Phospholipase A(2) Gene in a Specified Segment of Protobothrops flavoviridis Genome and Its Possible Evolutionary Relationship to Group IIA Phospholipase A(2) Genes. TOXINS 6:3471-3487(2014).
Karray, A; Ben Ali, Y; et al. Drastic changes in the tissue-specific expression of secreted phospholipases A2 in chicken pulmonary disease. BIOCHIMIE 94:451-460(2012).
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