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PMP22

  • Official Full Name

    peripheral myelin protein 22

  • Overview

    PMP-22 (Peripheral Myelin Protein) is a glycoprotein expressed in the compact myolin of the peripheral nervous system. In the peripheral nervous system, PMP-22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) and protein P0 during nerve development and regeneration. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot-Marie-Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies.
  • Synonyms

    PMP22; peripheral myelin protein 22; GAS 3; HNPP; Sp110; PMP-22; growth arrest-specific 3; growth arrest-specific protein 3; DSS; CMT1A; CMT1E; GAS-3; HMSNIA; MGC20769;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Equus caballus (Horse)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PMP22-30010TH Recombinant Human PMP22 Wheat Germ N/A 160 amino acids
Human PMP22-8045H Recombinant Human PMP22 protein, His & T7-tagged E.coli His/T7 Met1~Glu160 (Accession # Q01453)
Human PMP22-1810H Recombinant Human PMP22, GST-tagged E.coli GST 31-133aa
Human PMP22-30913TH Recombinant Human PMP22 Wheat Germ N/A 90 amino acids
Human PMP22-1718H Recombinant Human PMP22 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PMP22-4473H Recombinant Human PMP22 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PMP22-2147H Recombinant Human PMP22 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PMP22-1034H Recombinant Human PMP22 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PMP22-1718H-B Recombinant Human PMP22 Protein Pre-coupled Magnetic Beads HEK293
Human PMP22-374HF Recombinant Full Length Human PMP22 Protein In Vitro Cell Free System 160 amino acids
Human PMP22-1811H Recombinant Human PMP22 Protein, His-tagged E.coli His 31-133 aa
Human PMP22-504HFL Recombinant Full Length Human PMP22 Protein, C-Flag-tagged Mammalian cells Flag
Human PMP22-1812H Recombinant Human PMP22 Protein, His-SUMO-tagged E.coli His-SUMO Gly31~Gly133
Human PMP22-4943H Recombinant Human PMP22 Protein (Gly31-Gly133), N-His tagged E.coli N-His Gly31-Gly133
Mouse PMP22-13017M Recombinant Mouse PMP22 Protein Mammalian Cell His
Mouse Pmp22-4957M Recombinant Mouse Pmp22 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PMP22-6876M-B Recombinant Mouse PMP22 Protein Pre-coupled Magnetic Beads HEK293
Mouse Pmp22-1955M Recombinant Mouse Pmp22 Protein, His&GST-tagged E.coli N-His&GST Met1-Ser64
Mouse PMP22-6876M Recombinant Mouse PMP22 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PMP22-4542R Recombinant Rat PMP22 Protein Mammalian Cell His
Rat PMP22-4202R-B Recombinant Rat PMP22 Protein Pre-coupled Magnetic Beads HEK293
Rat Pmp22-2389R Recombinant Rat Pmp22 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-160aa
Rat PMP22-4202R Recombinant Rat PMP22 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL34481BF Recombinant Full Length Bovine Peripheral Myelin Protein 22(Pmp22) Protein, His-Tagged E.coli expression system His Full Length (1-160)
Equus caballus (Horse) RFL2736EF Recombinant Full Length Horse Peripheral Myelin Protein 22(Pmp22) Protein, His-Tagged E.coli expression system His Full Length (1-159)
Homo sapiens (Human) RFL464HF Recombinant Full Length Human Peripheral Myelin Protein 22(Pmp22) Protein, His-Tagged E.coli expression system His Full Length (1-160)
Mus musculus (Mouse) RFL7720MF Recombinant Full Length Mouse Peripheral Myelin Protein 22(Pmp22) Protein, His-Tagged E.coli expression system His Full Length (1-161)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL14546PF Recombinant Full Length Pongo Abelii Peripheral Myelin Protein 22(Pmp22) Protein, His-Tagged E.coli expression system His Full Length (1-160)
Rattus norvegicus (Rat) RFL25006RF Recombinant Full Length Rat Peripheral Myelin Protein 22(Pmp22) Protein, His-Tagged E.coli expression system His Full Length (1-160aa)
Rhesus Macaque PMP22-3486R Recombinant Rhesus monkey PMP22 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PMP22-3304R Recombinant Rhesus Macaque PMP22 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PMP22-3304R-B Recombinant Rhesus Macaque PMP22 Protein Pre-coupled Magnetic Beads HEK293
Chicken PMP22-4716C Recombinant Chicken PMP22 Mammalian Cell His
Chicken PMP22-4717C Recombinant Chicken PMP22 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PMP22 Related Articles

PMP22 involved in several pathways and played different roles in them. We selected most pathways PMP22 participated on our site, such as Neural Crest Differentiation, a6b1 and a6b4 Integrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMP22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neural Crest DifferentiationOLIG3;OLIG1;LHX1;DLL3;ASCL1;GBX2;TXLNB;CDH7;DLX5
a6b1 and a6b4 Integrin signalingMST1;MST1R;PMP22

PMP22 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PMP22 itself. We selected most functions PMP22 had, and list some proteins which have the same functions with PMP22. You can find most of the proteins on our site.

Function Related Protein
protein bindingELF2;XBP1;MCM8;DHX16;MPDU1;MYO9B;SLBP;TLE1;SLC6A18

PMP22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMP22 here. Most of them are supplied by our site. Hope this information will be useful for your research of PMP22.

KLRC1; SMIM3; tyrB; gltD1; DDX52

Kalantari-Dehaghi, M; Anhalt, GJ; et al. Pemphigus Vulgaris Autoantibody Profiling by Proteomic Technique. PLOS ONE 8:-(2013).
Homs, J; Ariza, L; et al. Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration. GENE THERAPY 18:622-630(2011).
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