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PMS2

  • Official Full Name

    PMS2 postmeiotic segregation increased 2

  • Overview

    Microsatellite instability (MSI) is characterized by genome-wide alterations in short, repetitive DNA sequences. It is caused by defects in the nucleotide mismatch repair (MMR) system. Biologically, defective MMR results in a general increase in the mutat
  • Synonyms

    PMS2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2, postmeiotic segregation increased (S. cerevisiae) 2; mismatch repair endonuclease PMS2; H_DJ0042M02.9; HNPCC4; PMS1 protein homolog 2; DNA mismatch repair protein PMS2; PMSL2; PMS2CL;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • E. coli
  • HEK293
  • HEK293T
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PMS2-1383HCL Recombinant Human PMS2 cell lysate N/A
Human PMS2-1017H Recombinant Human PMS2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PMS2-1720H Recombinant Human PMS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PMS2-197H Recombinant Human PMS2 protein, His-tagged E. coli His 513-862 aa
Human PMS2-1720H-B Recombinant Human PMS2 Protein Pre-coupled Magnetic Beads HEK293
Human PMS2-1490HFL Recombinant Full Length Human PMS2 Protein, C-Flag-tagged Mammalian cells Flag
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PMS2 Related Articles
  • PMS2 Related Research Area

PMS2 involved in several pathways and played different roles in them. We selected most pathways PMS2 participated on our site, such as Mismatch repair, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mismatch repairMLH1;MLH3;RFC1;RFC3;POLD2;LIG1;PCNA;RPA3;EXO1
Fanconi anemia pathwayHER6;FUZ;FANCF;BLM;BRCA1;RAD51C;TOP3A;ATRIP;REV3L

PMS2 has several biochemical functions, for example, ATP binding, ATPase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PMS2 itself. We selected most functions PMS2 had, and list some proteins which have the same functions with PMS2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMYH9;UBE1Y1;DHX9;PRKACB;MCMDC2;NTRK2B;ERCC6L;CHUK;SHPK
ATPase activitySMARCA5;ATAD1B;RHOBTB3;KIF2A;TOR1B;VCP;HSP90AA1;KIF27;KIF13B
DNA bindingHIST1H2AG;NR2F1B;PBX1;POLE2;HOXB7A;ZNF354B;TBX6;ZNF654;ZFP771
contributes_to MutSalpha complex bindingMLH1;PMS2
endonuclease activitySETMAR;FEN1;ERN2;RSFR;ANG;MRE11A;PNKP;PMS2;ZC3H12A
protein bindingHOXA10;S100P;KLF15;ANXA9;PRKAR1A;ABCD2;ROCK2;SPN;MTA3
single base insertion or deletion binding
contributes_to single-stranded DNA bindingIGJ;POLR2D;PMS2;MSH2;IGHM;MSH3;MLH1

PMS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PMS2.

MLH1; BRIP1; FSCN1; ZNF189; RASA1; XPA; AKT1; PPP2CB

Roth, RM; Hampel, H; et al. A Modified Lynch Syndrome Screening Algorithm in Colon Cancer BRAF Immunohistochemistry Is Efficacious and Cost Beneficial. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:336-343(2015).
Muro, Y; Nakashima, R; et al. Autoantibodies to DNA Mismatch Repair Enzymes in Polymyositis/Dermatomyositis and Other Autoimmune Diseases: A Possible Marker of Favorable Prognosis. ARTHRITIS & RHEUMATOLOGY 66:3457-3462(2014).
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