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POFUT2

Official Full Name

protein O-fucosyltransferase 2
Overview

Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 (PubMed 16464857)).
Synonyms

POFUT2; protein O-fucosyltransferase 2; C21orf80, chromosome 21 open reading frame 80; GDP-fucose protein O-fucosyltransferase 2; FUT13; KIAA0958; O-FucT-2; peptide-O-fucosyltransferase 2; C21orf80;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mamanlian cells
Mammalian Cell
Wheat Germ

Tag

Flag
GST
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POFUT2-1825H	Recombinant Human POFUT2, GST-tagged	E.coli	GST	21-429aa	$319 / 25ug
Human	POFUT2-3892H	Recombinant Human POFUT2 protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	POFUT2-27511TH	Recombinant Human POFUT2, His-tagged	E.coli	His		Inquiry
Human	POFUT2-285H	Recombinant Human POFUT2 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	POFUT2-3056HCL	Recombinant Human POFUT2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	POFUT2-903H	Recombinant Human POFUT2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	POFUT2-6576HFL	Recombinant Full Length Human POFUT2 protein, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	POFUT2-606HF	Recombinant Full Length Human POFUT2 Protein, GST-tagged	In Vitro Cell Free System	GST	429 amino acids	Inquiry
Mouse	Pofut2-4979M	Recombinant Mouse Pofut2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	POFUT2-4816Z	Recombinant Zebrafish POFUT2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
POFUT2 Related Articles

POFUT2 involved in several pathways and played different roles in them. We selected most pathways POFUT2 participated on our site, such as Other types of O-glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with POFUT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Other types of O-glycan biosynthesis	B3GALT4;B4GALT2;POGLUT1;GXYLT2;COLGALT2;ST6GAL2A;B3GAT2;OGT.1;ST6GAL1

POFUT2 has several biochemical functions, for example, peptide-O-fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POFUT2 itself. We selected most functions POFUT2 had, and list some proteins which have the same functions with POFUT2. You can find most of the proteins on our site.

Function	Related Protein
peptide-O-fucosyltransferase activity	POFUT1;POFUT2

POFUT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POFUT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POFUT2.

USP22; GABARAP; MAP1LC3A

Vasudevan, D; Takeuchi, H; et al. Peters Plus Syndrome Mutations Disrupt a Noncanonical ER Quality-Control Mechanism. CURRENT BIOLOGY 25:286-295(2015).

Muller, J; Rana, NA; et al. O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function. PLOS ONE 9:-(2014).