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PPARGC1A

  • Official Full Name

    peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

  • Overview

    The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
  • Synonyms

    PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 , peroxisome proliferative activated receptor, gamma, coactivator 1, alpha , PPARGC1; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC1; PGC1A; LEM6; Ligand effect modulator 6; Peroxisome proliferative activated receptor gamma coactivator 1 alpha; Peroxisome proliferative activated receptor gamma coactivator 1; Peroxisome proliferator activated receptor gamma coactivator 1 alpha; PGC 1 (alpha); PGC 1 alpha; PGC 1v; PGC-1-alpha; PGC1(alpha); PGC1v; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6; PPAR gamma coactivator 1 alpha; PPAR gamma coactivator 1; PPAR gamma coactivator 1-alpha; PPAR gamma coactivator variant form; PPAR-gamma coactivator 1-alpha; PPARGC 1 alpha; PPARGC-1-alpha; PPARGC1; PRGC1_HUMAN; OTTHUMP00000123372; ligand effect modulator-6; PGC-1v; PGC-1(alpha);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPARGC1A-729H Recombinant Human PPARGC1A Protein, His-tagged E.coli His Ser573~Asn767
Human PPARGC1A-8291H Recombinant Human PPARGC1A protein, GST-tagged Wheat Germ GST
Human PPARGC1A-2611H Recombinant Human PPARGC1A Protein, His-tagged E.coli N-His Glu350-Arg798
Mouse Ppargc1a-8492M Recombinant Mouse Ppargc1a protein, His-tagged E.coli His
Mouse PPARGC1A-13163M Recombinant Mouse PPARGC1A Protein Mammalian Cell His
Mouse Ppargc1a-1962M Recombinant Mouse Ppargc1a Protein, His-tagged E.coli N-His Glu349-Arg797
Mouse PPARGC1A-6970M Recombinant Mouse PPARGC1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PPARGC1A-6970M-B Recombinant Mouse PPARGC1A Protein Pre-coupled Magnetic Beads HEK293
Rat PPARGC1A-4594R Recombinant Rat Ppargc1a protein, His-tagged E.coli His Ser588~Ser773
Rat PPARgC1a-1248R Recombinant Rat PPARgC1a protein, His-tagged E.coli His Glu348~Arg796
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PPARGC1A Related Research Area

PPARGC1A involved in several pathways and played different roles in them. We selected most pathways PPARGC1A participated on our site, such as AMPK signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARGC1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AMPK signaling pathwayRAB10;PPP2R3C;ACACA;SCD5;AKT1;CPT1C;EEF2K;PPP2R2B;CPT1B
Insulin signaling pathwayTSC1;CALML3;PRKAA1;PIK3R5;BADB;CBLC;GRB2A;PRKCI;PHKG1A
Adipocytokine signaling pathwayACSL1B;RELA;RXRG;IRS1;NFKBIB;G6PC;ADIPOQ;G6PCA.1;G6PC3
Insulin resistanceNR1H2;NFKBIA;GYS2;RPS6KAL;PCK1;CREB3L2;PRKCE;FOXO1A;CREB3L3
Huntingtons diseaseAPAF1;TBPL1;UQCRC1;PPARGC1A;NDUFV1;GPX1;CREB3L2;SDHD;COX8C

PPARGC1A has several biochemical functions, for example, DNA binding, RNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARGC1A itself. We selected most functions PPARGC1A had, and list some proteins which have the same functions with PPARGC1A. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF786;AHR;SIM1B;MAFBB;RXRBA;ZBTB8B;ZNF710;NR1D2A;ESR2
RNA bindingNUFIP2;PUF60B;EXOSC3;ZFP385C;DAZL;DDX43;SRSF3;FARSB;MIF4GDB
RNA polymerase II transcription cofactor activityMED31;MED30;MED24;CRSP7;MED21;RBM14;MED4;MED20;MED13A
alpha-tubulin bindingOFD1;WASH1;TRPV4;PROL1;SLC6A2;SNCA;RACGAP1;SERPINB1A;WASH
chromatin DNA bindingMED1;RARA;INSM1A;ACTN4;GRHL1;NOTCH1;VAX1;EZH2;CLOCK
chromatin bindingDMRT1;NKAP;NUPR1;MSL1;SETD7;ZFP354B;HDAC7;POLD1;SMARCC1
estrogen receptor bindingTAF10;FOXL2;NCOA1;PCNA;ISL1;PADI2;TMEM38A;CNOT1;TRIP4
ligand-dependent nuclear receptor bindingMED1;NCOA3;NCOA2;NCOR2;PPARGC1A;UBA3;TADA3;NCOA1;ARID1A
ligand-dependent nuclear receptor transcription coactivator activityMED14;MED1;RBM14;ATXN7L3;BUD31;TSG101;WDR77;PRKCB;SFR1
nucleic acid bindingZCCHC16;SMFN;SSX5;ZNF281B;ZFP583;ZFP740;SALL1A;NTNG1;DDX39AA
nucleotide bindingCPSF6;RHOGD;ARF3A;ACTB2;RBM23;RNPC3;HNRNPH1L;SREK1;CDK14
peroxisome proliferator activated receptor bindingMED1;PRMT2;ASXL1;NR0B2;PPARGC1A;HMGA1-RS1;HMGA1;ASXL2;CREBBP
promoter-specific chromatin binding
protein bindingHJURP;ID3;NBN;CDK1;PHYHIPL;HSPA1L;TRP53;C17orf59;BRIP1
sequence-specific DNA bindingBCL11AB;FOXD4L1;ARXA;HLX;PRRX1B;PBX3B;PHOX2BB;CTCF;GSX1
transcription coactivator activityNACA;MCIN;SMARCB1;TFDP1A;BIRC2;NR1I2;THRAP3;TAF7L;MTF1
transcription factor bindingHIF1A;GNPTAB;ENPP2;HDAC1;DDIT3;RNF4;TRIB1;UBE2I;KAT6B
ubiquitin protein ligase bindingXRCC5;ABI2;POU5F1;WFS1;BLZF1;UBE2O;RRAGA;TNFRSF1B;CLU

PPARGC1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARGC1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARGC1A.

Sirt1; Irf4; Lrpprc; LRPPRC; IQGAP1; EP300; SIRT1; NR1I2

  • Q&As
  • Reviews

Q&As (7)

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What role does PPARGC1A play in thermogenesis and the function of brown adipose tissue? 11/17/2022

PPARGC1A is crucial for thermogenesis, particularly in brown adipose tissue, aiding in heat production.

What therapeutic strategies are being explored that involve modulation of PPARGC1A for disease treatment? 04/24/2022

Therapeutic strategies targeting PPARGC1A aim to modulate its activity to treat metabolic disorders and enhance mitochondrial function.

What is the central role of PPARGC1A (PGC-1α) in cellular energy metabolism? 09/30/2021

PPARGC1A is a master regulator of energy metabolism, coordinating various metabolic pathways.

In which tissues is PPARGC1A predominantly expressed? 04/21/2021

PPARGC1A is highly expressed in tissues with high energy demands, such as muscles and brown adipose tissue.

Are there known genetic variations in PPARGC1A associated with specific health conditions? 10/29/2020

Genetic variations in PPARGC1A have been associated with altered metabolic function and disease susceptibility.

How is PPARGC1A implicated in metabolic disorders like diabetes and obesity? 03/11/2019

Dysregulation of PPARGC1A is linked to metabolic disorders, including diabetes and obesity.

How does PPARGC1A contribute to mitochondrial biogenesis? 02/06/2018

It stimulates mitochondrial biogenesis, enhancing cellular energy production.

Customer Reviews (3)

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Reviews
09/11/2022

    Quality product, worked well.

    05/10/2022

      Very happy, will reorder.

      07/02/2021

        Worked perfectly in tests.

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