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PPIA

  • Official Full Name

    peptidylprolyl isomerase A (cyclophilin A)

  • Overview

    This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms

    PPIA; peptidylprolyl isomerase A (cyclophilin A); CYPA; CYPH; HEL-S-69p; peptidyl-prolyl cis-trans isomerase A; PPIase A; rotamase A; cyclophilin; T cell cyclophilin; cyclosporin A-binding protein; epididymis secretory sperm binding protein Li 69p;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • E.coli
  • Escherichia coli O6:H1
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • His|SUMO
  • SUMO
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPIA-26334TH Active Recombinant Human PPIA E.coli N/A 1-165 aa
Human PPIA-8311H Active Recombinant Human PPIA, His tagged E.coli His
Human PPIA-22H Recombinant Human PPIA protein, GST-tagged E.coli GST 1-165 aa (full-length)
Human PPIA-26337TH Recombinant Human PPIA N/A
Human PPIA-60H Recombinant Human PPIA, His-tagged E.coli His
Human PPIA-1140H Recombinant Human PPIA protein, His-tagged E.coli His Met1-Glu165
Human PPIA-187H Recombinant Human PPIA Mammalian Cell His
Human PPIA-2975HCL Recombinant Human PPIA 293 Cell Lysate HEK293 N/A
Human PPIA-1743H-B Recombinant Human PPIA Protein Pre-coupled Magnetic Beads HEK293
Human PPIA-001H Recombinant Human PPIA Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human PPIA-4081H Recombinant Human PPIA protein, GST-tagged E.coli GST 2-165aa
Human PPIA-50HFL Recombinant Full Length Human PPIA Protein, C-Flag-tagged Mammalian cells Flag
Human PPIA-1743H Recombinant Human PPIA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PPIA-4080H Recombinant Human PPIA protein, His&Myc-tagged E.coli His&Myc 1-165aa
Human PPIA-0216H Recombinant Human PPIA Protein (M1-E165), Tag Free E.coli No tag M1-E165
Human PPIA-4082H Recombinant Human PPIA protein E.coli N/A 2-165aa
Human PPIA-0217H Recombinant Human PPIA Protein (M1-E165), His/Strep tagged E.coli His/Strep M1-E165
Human PPIA-5945H Recombinant Human PPIA Protein (Val2-Glu165), N-His tagged E.coli N-His Val2-Glu165
Mouse Ppia-871M Recombinant Mouse Ppia protein, His-tagged E.coli His Met1-Leu164
Mouse PPIA-13179M Recombinant Mouse PPIA Protein Mammalian Cell His
Mouse PPIA-6978M Recombinant Mouse PPIA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ppia-872M Recombinant Mouse Ppia Protein E.coli N/A
Mouse PPIA-6978M-B Recombinant Mouse PPIA Protein Pre-coupled Magnetic Beads HEK293
Mouse Ppia-5038M Recombinant Mouse Ppia Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ppia-7385M Recombinant Mouse Ppia Protein, His-tagged E.coli His 1-164
Rat Ppia-5691R Recombinant Rat Ppia protein, His-tagged E.coli His Val2~Leu164 (Accession # P10111)
Rat PPIA-4600R Recombinant Rat PPIA Protein Mammalian Cell His
Rat PPIA-4259R-B Recombinant Rat PPIA Protein Pre-coupled Magnetic Beads HEK293
Rat PPIA-4259R Recombinant Rat PPIA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey PPIA-5692R Recombinant Rhesus monkey PPIA protein, His-tagged E.coli His Val2~Glu165 (Accession # P62940)
Cattle PPIA-5689C Recombinant Cattle PPIA protein, His-tagged E.coli His Val2~Ile164 (Accession # P62935)
E.coli PPIA-2096E Recombinant Escherichia coli O157:H7 PPIA Protein (25-190 aa), His-SUMO-tagged E.coli His/SUMO 25-190 aa
Escherichia coli O6:H1 ppiA-4242E Recombinant Escherichia coli O6:H1 ppiA protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 25-190aa
Rhesus Macaque PPIA-3543R Recombinant Rhesus monkey PPIA Protein, His-tagged Mammalian Cell His
Rhesus Macaque PPIA-3361R-B Recombinant Rhesus Macaque PPIA Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PPIA-3361R Recombinant Rhesus Macaque PPIA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig PPIA-5690P Recombinant Pig PPIA protein, His-tagged E.coli His Val2~Ile164 (Accession # P62936)
Chicken PPIA-4005C Recombinant Chicken PPIA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PPIA Related Articles
  • PPIA Related Research Area

PPIA involved in several pathways and played different roles in them. We selected most pathways PPIA participated on our site, such as APOBEC3G mediated resistance to HIV-1 infection, Assembly Of The HIV Virion, Basigin interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPIA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
APOBEC3G mediated resistance to HIV-1 infectionBANF1;APOBEC3G;gag;PPIA;PSIP1;HMGA1
Assembly Of The HIV VirionPPIA;NMT2;VPS37A;gag
Basigin interactionsPPIA;SLC7A10;SLC3A2B;SLC7A6;SLC7A11;SLC16A1;NADL1.1;SLC7A8A;SLC3A2A
Binding and entry of HIV viriongag;PPIA;CCR5
Budding and maturation of HIV viriongag;PDCD6IP;CHMP4B;VPS37A;CHMP4C;PPIA
Cell surface interactions at the vascular wallANGPT2A;GAS6;GRB7;SLC7A11;F11R.2;GRB14;CEACAM8;GLG1B;SLC16A1
DiseaseFDX1;MTRR;TRIM24;HMGA1;CCDC59;PACS1;CPSF6;LRRFIP1;SFTPB
Early Phase of HIV Life CycleBANF1;PPIA;PSIP1;gag;CCR5

PPIA has several biochemical functions, for example, peptide binding, peptidyl-prolyl cis-trans isomerase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPIA itself. We selected most functions PPIA had, and list some proteins which have the same functions with PPIA. You can find most of the proteins on our site.

Function Related Protein
peptide bindingNpepo;ANG;NLN;ERCC3;OXTRL;BDKRB1;RNPEPL1;CLTB;RPS6KB2
peptidyl-prolyl cis-trans isomerase activityPPIL6;PPID;FKBP1B;RANBP2;PPIL3;FKBP4;TTC9C;FKBP3;PPIE
poly(A) RNA bindingTFAM;IGF2BP1;PIN4;PSMC1;PWP2;NUSAP1;DNM1;RPS9;RBM4B
protein bindingZFYVE1;FAM86A;UBA7;EPC1;LXN;FIBPB;HDAC6;AIMP1;HIST1H3H
unfolded protein bindingSIL1;MKKS;PFDN4;CALR;DNAJB6;PPIA;HSP90AB1;SERPINH1;APCS
virion bindingPPIA;HIPK2;PVRL1;PTX3;CD209;HSP90B1;APCS;CLEC4M;TSG101

PPIA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPIA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPIA.

gag; q99ib8-pro_0000045602; LNX1; SUPT5H; PTPRN; AIFM1; gag-pol

Lacombe, J; Mange, A; et al. A Multiparametric Serum Marker Panel as a Complementary Test to Mammography for the Diagnosis of Node-Negative Early-Stage Breast Cancer and DCIS in Young Women. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 23:1834-1842(2014).
Garibo, D; Flores, C; et al. Inhibition equivalency factors for microcystin variants in recombinant and wild-type protein phosphatase 1 and 2A assays. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 21:10652-10660(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can PPIA be used as a therapeutic target for infectious diseases? 10/17/2022

PPIA has been studied in the context of infectious diseases, particularly in viral infections, as a potential therapeutic target.

Are there any side effects associated with drugs that target PPIA? 07/07/2022

Some drugs targeting PPIA may have side effects, including immunosuppression, which needs to be carefully managed.

Is PPIA used in organ transplantation procedures? 07/04/2021

Yes, PPIA has been studied in the context of organ transplantation due to its role in immune responses and immunosuppression.

Can PPIA be used as a potential drug target for neuroprotective therapies? 04/09/2019

PPIA modulation has shown promise in neuroprotection, making it a potential drug target for neurodegenerative disorders.

Are there any drugs that target PPIA for clinical use? 05/11/2017

Some drugs, such as cyclosporine, target PPIA for immunosuppressive purposes in transplantation and autoimmune diseases.

Customer Reviews (3)

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Reviews
03/04/2022

    The PPIA protein's robustness and stability have contributed significantly to the success of my experiments, enabling precise and reproducible measurements.

    05/31/2020

      I highly recommend the PPIA protein for a wide range of research applications.

      06/16/2019

        Its exceptional performance, in combination with its clear and distinct protein bands, make it an absolute must-have for researchers looking to achieve accurate and reliable results in their experiments.

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