PPIA
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Official Full Name
peptidylprolyl isomerase A (cyclophilin A)
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Overview
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
PPIA; peptidylprolyl isomerase A (cyclophilin A); CYPA; CYPH; HEL-S-69p; peptidyl-prolyl cis-trans isomerase A; PPIase A; rotamase A; cyclophilin; T cell cyclophilin; cyclosporin A-binding protein; epididymis secretory sperm binding protein Li 69p;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- E.coli
- Escherichia coli O6:H1
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- Rhesus monkey
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Strep
- His|SUMO
- SUMO
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- PPIA Related Articles
- PPIA Related Research Area
PPIA involved in several pathways and played different roles in them. We selected most pathways PPIA participated on our site, such as APOBEC3G mediated resistance to HIV-1 infection, Assembly Of The HIV Virion, Basigin interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPIA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
APOBEC3G mediated resistance to HIV-1 infection | BANF1;APOBEC3G;gag;PPIA;PSIP1;HMGA1 |
Assembly Of The HIV Virion | PPIA;NMT2;VPS37A;gag |
Basigin interactions | PPIA;SLC7A10;SLC3A2B;SLC7A6;SLC7A11;SLC16A1;NADL1.1;SLC7A8A;SLC3A2A |
Binding and entry of HIV virion | gag;PPIA;CCR5 |
Budding and maturation of HIV virion | gag;PDCD6IP;CHMP4B;VPS37A;CHMP4C;PPIA |
Cell surface interactions at the vascular wall | ANGPT2A;GAS6;GRB7;SLC7A11;F11R.2;GRB14;CEACAM8;GLG1B;SLC16A1 |
Disease | FDX1;MTRR;TRIM24;HMGA1;CCDC59;PACS1;CPSF6;LRRFIP1;SFTPB |
Early Phase of HIV Life Cycle | BANF1;PPIA;PSIP1;gag;CCR5 |
PPIA has several biochemical functions, for example, peptide binding, peptidyl-prolyl cis-trans isomerase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPIA itself. We selected most functions PPIA had, and list some proteins which have the same functions with PPIA. You can find most of the proteins on our site.
Function | Related Protein |
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peptide binding | Npepo;ANG;NLN;ERCC3;OXTRL;BDKRB1;RNPEPL1;CLTB;RPS6KB2 |
peptidyl-prolyl cis-trans isomerase activity | PPIL6;PPID;FKBP1B;RANBP2;PPIL3;FKBP4;TTC9C;FKBP3;PPIE |
poly(A) RNA binding | TFAM;IGF2BP1;PIN4;PSMC1;PWP2;NUSAP1;DNM1;RPS9;RBM4B |
protein binding | ZFYVE1;FAM86A;UBA7;EPC1;LXN;FIBPB;HDAC6;AIMP1;HIST1H3H |
unfolded protein binding | SIL1;MKKS;PFDN4;CALR;DNAJB6;PPIA;HSP90AB1;SERPINH1;APCS |
virion binding | PPIA;HIPK2;PVRL1;PTX3;CD209;HSP90B1;APCS;CLEC4M;TSG101 |
PPIA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPIA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPIA.
gag; q99ib8-pro_0000045602; LNX1; SUPT5H; PTPRN; AIFM1; gag-pol
- Q&As
- Reviews
Q&As (5)
Ask a questionPPIA has been studied in the context of infectious diseases, particularly in viral infections, as a potential therapeutic target.
Some drugs targeting PPIA may have side effects, including immunosuppression, which needs to be carefully managed.
Yes, PPIA has been studied in the context of organ transplantation due to its role in immune responses and immunosuppression.
PPIA modulation has shown promise in neuroprotection, making it a potential drug target for neurodegenerative disorders.
Some drugs, such as cyclosporine, target PPIA for immunosuppressive purposes in transplantation and autoimmune diseases.
Customer Reviews (3)
Write a reviewThe PPIA protein's robustness and stability have contributed significantly to the success of my experiments, enabling precise and reproducible measurements.
I highly recommend the PPIA protein for a wide range of research applications.
Its exceptional performance, in combination with its clear and distinct protein bands, make it an absolute must-have for researchers looking to achieve accurate and reliable results in their experiments.
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