PPP1R8
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Official Full Name
protein phosphatase 1, regulatory subunit 8
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Overview
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. -
Synonyms
PPP1R8; protein phosphatase 1, regulatory subunit 8; protein phosphatase 1, regulatory (inhibitor) subunit 8; nuclear inhibitor of protein phosphatase 1; activator of RNA decay; ard 1; ARD1; NIPP 1; NIPP1; nuclear subunit of PP 1; PRO2047; protein phospha;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PPP1R8 Related Articles
PPP1R8 involved in several pathways and played different roles in them. We selected most pathways PPP1R8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
PPP1R8 has several biochemical functions, for example, DNA binding, RNA binding, endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R8 itself. We selected most functions PPP1R8 had, and list some proteins which have the same functions with PPP1R8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF643;ZNF596;PRKRIR;MSXB;RAD50;DLX4B;GLI4;ZNF221;TA |
| RNA binding | KIAA0430;CRNKL1;MKI67IP;CELF6;NHP2L1;LSM5;PTBP1B;ADAD2;KIN |
| endonuclease activity | CL2;RNASEL3;RNASE6;PPP1R8;EAR2;DROSHA;ANG;SETMAR;EME1 |
| protein binding | DOCK2;ZNF329;NRP1B;XRN1;DNAIC2;GATAD2B;MEPE;GMCL1P1;CBY1 |
| protein phosphatase type 1 regulator activity | PPP1R16B;PHACTR1;PPP1R7;NSFL1C;PHACTR3;KCNS1;UBXN2B;PPP1R8;PPP1R15A |
| protein serine/threonine phosphatase inhibitor activity | PPP1R1C;PPP1R17;PPP1R14C;PPP1R1A;PPP1R8;PPP1R11 |
| ribonuclease E activity |
PPP1R8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R8.
PPP1CA; PPP1CB; APPBP2; PPP1CC; CDC5L; LRRK2; NME2; SF3A2; Cep72; STC2; GBP2; CRMP1; SETDB1
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