ppt1
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  • Official Full Name
  • palmitoyl-protein thioesterase 1
  • Background
  • The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • PPT1; palmitoyl-protein thioesterase 1; PPT; ceroid lipofuscinosis; neuronal 1; infantile; CLN1; INCL; PPT-1; palmitoyl-protein hydrolase 1; ceroid-palmitoyl-palmitoyl-protein thioesterase 1
Cat.#:Ppt1-534MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ppt1 Protein, His-tagged
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Cat.#:PPT1-29543THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PPT1
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Cat.#:PPT1-366HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PPT1, Fc-tagged
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Cat.#:PPT1-367HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PPT1, His-tagged
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Cat.#:PPT1-652HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPT1 Protein, His-tagged
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Cat.#:PPT1-13281MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPT1 Protein
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Cat.#:PPT1-4647RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPT1 Protein
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Cat.#:PPT1-808CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PPT1 Protein, His-tagged
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Cat.#:PPT1-3581RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPT1 Protein, His-tagged
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Cat.#:PPT1-2592CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPT1
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Cat.#:PPT1-12524ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPT1
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Cat.#:PPT1-001HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PPT1 cell lysate
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Involved Pathway

PPT1 involved in several pathways and played different roles in them. We selected most pathways PPT1 participated on our site, such as Fatty acid elongation, Metabolic pathways, Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fatty acid elongation
HADH; ACAA2; HSD17B12; MECR; ELOVL7A; ELOVL1B; ELOVL1; ELOVL4A; ELOVL5; HADHAA
Metabolic pathways
GALNT5; ETNPPL; ACOX3; OGDH; ST3GAL1; SQLE; PEMT; ALAS2; UGP2; UQCR10
Fatty acid metabolism
Scd1; PTPLA; ELOVL2; ACAA1; SCD; CPT2; FADS1; ACADS; ACSL3; SCD5
Lysosome
ENTPD4; AP1S2; LIPA; GALNS; TCEAL4; ARSB; CD164; DNASE2; CTSL1B; ASAH1A

Protein Function

PPT1 has several biochemical functions, for example, palmitoyl-(protein) hydrolase activity, palmitoyl-CoA hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPT1 itself. We selected most functions PPT1 had, and list some proteins which have the same functions with PPT1. You can find most of the proteins on our site.
Function
Related Protein
Function palmitoyl-(protein) hydrolase activity
Related Protein PPT2; LYPLA2; LYPLAL1; PPT1; LYPLA1
Function palmitoyl-CoA hydrolase activity
Related Protein ACOT2; PPT1; ACOT8; THEM4; BAAT; THEM5; GNPAT; ACOT1; ACOT7; ACOT5

Interacting Protein

PPT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPT1.
GNAQ; ompR; pi3p; 15-deoxy-delta(12,14; MYC; cona_canen; 1C; VCAM1

PPT1 Related Articles

Hu, J; Lu, JY; et al. Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis. MOLECULAR GENETICS AND METABOLISM 107:213-221(2012).
Chu-LaGraff, Q; Blanchette, C; et al. The Batten Disease Palmitoyl Protein Thioesterase 1 Gene Regulates Neural Specification and Axon Connectivity during Drosophila Embryonic Development. PLOS ONE 5:-(2010).