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PRDX4

  • Official Full Name

    peroxiredoxin 4

  • Overview

    The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.
  • Synonyms

    PRDX4; peroxiredoxin 4; peroxiredoxin-4; AOE37 2; prx-IV; peroxiredoxin IV; antioxidant enzyme AOE372; thioredoxin peroxidase AO372; thioredoxin peroxidase (antioxidant enzyme); thioredoxin-dependent peroxide reductase A0372; PRX-4; AOE37-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • N
  • Flag
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRDX4-1022H Recombinant Human PRDX4 E.coli N/A
Human PRDX4-2048H Recombinant Human Peroxiredoxin 4, His-tagged E.coli His
Human PRDX4-30466TH Recombinant Human PRDX4, His-tagged E.coli His
Human PRDX4-2880HCL Recombinant Human PRDX4 293 Cell Lysate HEK293 N/A
Human PRDX4-1759H-B Recombinant Human PRDX4 Protein Pre-coupled Magnetic Beads HEK293
Human PRDX4-322H Recombinant Human PRDX4 Protein, His-tagged E.coli His Leu6~Trp249
Human PRDX4-2845H Recombinant Human PRDX4 protein(71-260 aa), C-His-tagged E. coli C-His 71-260 aa
Human PRDX4-700H Recombinant Human PRDX4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRDX4-2119HFL Recombinant Full Length Human PRDX4 Protein, C-Flag-tagged Mammalian cells Flag
Human PRDX4-1759H Recombinant Human PRDX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRDX4-5554H Recombinant Human PRDX4 Protein (Leu6-Trp249), His tagged E.coli His Leu6-Trp249
Human PRDX4-3910H Recombinant Human PRDX4 Protein (Trp38-Asn271), N-His tagged E.coli N-His Trp38-Asn271
Human PRDX4-3911H Recombinant Human PRDX4 Protein (Met1-Asn271), C-His and N-His tagged E.coli C-His and N-His Met1-Asn271
Mouse PRDX4-13325M Recombinant Mouse PRDX4 Protein Mammalian Cell His
Mouse PRDX4-7072M-B Recombinant Mouse PRDX4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Prdx4-323M Recombinant Mouse Prdx4 Protein, His-tagged E.coli His Ser14~Thr258
Mouse Prdx4-5103M Recombinant Mouse Prdx4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PRDX4-7072M Recombinant Mouse PRDX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRDX4-4660R Recombinant Rat PRDX4 Protein Mammalian Cell His
Rat PRDX4-4319R-B Recombinant Rat PRDX4 Protein Pre-coupled Magnetic Beads HEK293
Rat PRDX4-4319R Recombinant Rat PRDX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRDX4-3592R Recombinant Rhesus monkey PRDX4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRDX4-3410R Recombinant Rhesus Macaque PRDX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRDX4-3410R-B Recombinant Rhesus Macaque PRDX4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRDX4-5551Z Recombinant Zebrafish PRDX4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PRDX4 involved in several pathways and played different roles in them. We selected most pathways PRDX4 participated on our site, such as Selenium Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Selenium PathwayPRDX3;SAA2-SAA4;DIO2;MSRB1;SELK;SAA4;SEP15;SAA2;PRDX4

PRDX4 has several biochemical functions, for example, protein binding, protein homodimerization activity, thioredoxin peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX4 itself. We selected most functions PRDX4 had, and list some proteins which have the same functions with PRDX4. You can find most of the proteins on our site.

Function Related Protein
protein bindingCD200R4;RASD1;ACAN;GORAB;NSG1;SMC1A;MIB1;FAM46A;SNX20
protein homodimerization activityTOX3;NAMPT;ECT2;HOMER2;NR4A2;BHLHE40;GRIK2;APOE;FGFR2
thioredoxin peroxidase activityPRDX1;PRDX4;PRDX2;PRDX3

PRDX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX4.

LBP; TBXA2R; NR4A1; PDIA6; P4HB; PDIA3; TXNDC5; CLIC1; MT-CO1; PLG

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary biological role of PRDX4 in cells? 05/09/2022

PRDX4 acts as a peroxidase, reducing peroxides to protect cells from oxidative stress.

What role does PRDX4 play in protein folding and quality control? 08/15/2020

It assists in protein folding and prevents the aggregation of misfolded proteins.

In which cellular compartments is PRDX4 primarily located? 07/14/2020

PRDX4 is primarily located in the endoplasmic reticulum and secreted extracellularly.

Are there potential therapeutic applications targeting PRDX4? 06/15/2020

Therapeutic applications may involve modulating PRDX4 activity to mitigate oxidative stress-related diseases.

How does PRDX4 contribute to the cellular antioxidant defense system? 10/18/2019

It reduces hydrogen peroxide and lipid peroxides, contributing to the antioxidant defense.

How is the activity of PRDX4 regulated within cells? 01/01/2019

Cellular redox status and covalent modifications regulate PRDX4 activity.

What happens when there is dysregulation or deficiency of PRDX4? 10/13/2018

PRDX4 deficiency can lead to increased oxidative stress and damage, affecting cellular functions.

Customer Reviews (3)

Write a review
Reviews
12/07/2021

    Delivery on time, perfect.

    01/19/2021

      Very effective protein product.

      10/24/2020

        High-quality, great for research.

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