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PRKACA

  • Official Full Name

    protein kinase, cAMP-dependent, catalytic, alpha

  • Overview

    cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the;cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The;inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the;dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric;catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans.;The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of;cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been;observed.
  • Synonyms

    PRKACA; protein kinase, cAMP-dependent, catalytic, alpha; cAMP-dependent protein kinase catalytic subunit alpha; PKACa; PKA C-alpha; protein kinase A catalytic subunit; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; MGC48865; MGC102831;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Dog
  • Human
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • C
  • His
  • DDK
  • GST
  • His (Fc)
  • Avi
  • Myc
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKACA-552H Active Recombinant Human PRKACA, GST-tagged Sf9 Insect Cell GST
Human PRKACA-149HFL Recombinant Full Length Human PRKACA Protein E. coli Full Length
Human PRKACA-394H Recombinant Human PRKACA, GST-tagged, Active Sf9 Insect Cell GST
Human PRKACA-31113TH Recombinant Human PRKACA E.coli N/A
Human PRKACA-547H Recombinant Human PRKACA Mammalian Cell His
Human PRKACA-55643H Recombinant Human PRKACA, GST-tagged E.coli GST False
Human PRKACA-1415HCL Recombinant Human PRKACA cell lysate N/A
Human PRKACA-2952H Recombinant Human PRKACA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PRKACA-3492H Recombinant Human PRKACA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRKACA-0816H Recombinant Human PRKACA Protein (G2-F351), Tag Free Insect Cell No tag G2-F351
Human PRKACA-2674H Recombinant Human PRKACA protein(11-350 aa), C-His-tagged E. coli C-His 11-350 aa
Human PRKACA-3369H Recombinant Human PRKACA protein, His-tagged E.coli His 2-351aa
Human PRKACA-2051HF Active Recombinant Full Length Human PRKACA Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-351(end)
Human PRKACA-3908H-B Recombinant Human PRKACA Protein Pre-coupled Magnetic Beads HEK293
Human PRKACA-1917H Recombinant Human PRKACA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRKACA-3908H Recombinant Human PRKACA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRKACA-2080HF Active Recombinant Full Length Human PRKACA Protein, GST-tagged Insect (sf21) GST 1-351(end)
Human PRKACA-3371H Recombinant Human PRKACA protein, His-tagged E.coli His 1-351 aa
Human PRKACA-010H Recombinant Human PRKACA protein, GST-tagged Insect Cell GST 1-351aa
Human PRKACA-0817H Recombinant Human PRKACA Protein (G2-F351), GST tagged Insect Cell GST G2-F351
Mouse PRKACA-13352M Recombinant Mouse PRKACA Protein Mammalian Cell His
Mouse Prkaca-608M Recombinant Mouse Prkaca E.coli N/A
Mouse PRKACA-7086M Recombinant Mouse PRKACA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PRKACA-7086M-B Recombinant Mouse PRKACA Protein Pre-coupled Magnetic Beads HEK293
Mouse Prkaca-5111M Recombinant Mouse Prkaca Protein, Myc/DDK-tagged HEK293T Myc/DDK
Dog PRKACA-4494D Recombinant Dog PRKACA protein, His-tagged E.coli His 2-350aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRKACA Related Research Area

PRKACA involved in several pathways and played different roles in them. We selected most pathways PRKACA participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNG7;FGF17;MAPK9;ACVR1C;RAF1;PPP3CCB;RPS6KA3B;PLA2G4D;GRB2A
Ras signaling pathwayPLA2G4C;PRKACB;PTPN11;PLCG1;PIK3CB;PDGFB;INS2;BCL2L1;CALM2
Calcium signaling pathwayTNNC1B;ADRA1D;PDGFRA;PRKACBA;PPP3CB;EDNRBA;CHRM3;ADRB2;VDAC3
cAMP signaling pathwayPLD2;PIK3CD;HCAR3;ATP2B4;PTCH1;CREB3L3;CAMK2D;VAV2;CREB3L2
Chemokine signaling pathwayPRKACG;LYN;Ccl21c;CXCL10;CCR9;ARRB2;STAT2;GNG13;HCK
Oocyte meiosisADCY1A;ITPR1;Adcy4;PPP2CA;PPP3R1;RPS6KA3B;RPS6KA1;PRKACBA;YWHABL
ApoptosisFASLG;PRKACB;PRKAR2A;CAPN1B;PIK3R2;CAPN1;DSG1;YWHAQ;NFKBIAB
Adrenergic signaling in cardiomyocytesTPM4;ADCY3;TNNC1A;MYH7;BCL2;GNAS;RAPGEF4;TPM1;TPMA
Vascular smooth muscle contractionGNA15.4;AVPR1A;CALM1A;GNAQ;PPP1R12A;PRKCDA;KCNMB1;PRKACG;PRKCBB
Wnt signaling pathwayRAC1;FZD3A;RHOAD;WNT9A;SFRP4;WNT7A;SOST;CSNK2A2A;RHOA
Hedgehog signaling pathwayWNT1;WNT10B;IHHB;GLI2B;WNT11B;GAS1A;WNT4A;WNT16;PTCH2
Gap junctionTUBA1C;MAP3K2;TUBA4L;ADRB3B;PDGFAB;TUBB2B;SOS1;Adcy4;HRAS
Platelet activationARHGEF12;PTGS1;GNAI3;MYLK3;TBXAS1;COL27A1;GP1BB;TBXA2R;BTK
Circadian entrainmentGNG12;KCNJ5;NOS1AP;CALM3;MTNR1B;AKR1C1;CACNA1G;GRIA2;GRIN2B
Long-term potentiationMAPK3;ITPR3;HRAS;CALML5;PPP1CB;BRAF;PRKACG;RPS6KA1;PRKCA
Retrograde endocannabinoid signalingGABRG1;GABRR2;PRKACA;MAPK3;GABRP;GABRD;GABRA3;GNG12;ABHD6
Glutamatergic synapseADRBK2;GNB4;PRKCA;GRIK5;GNG3;PLD1;SLC1A2;DLGAP1;GRIA4
Cholinergic synapseCREB3L2;CHRM4;CREB3;GNAI2;ACHE;AKT1;KCNQ1;FOS;CHAT
Serotonergic synapseCYP2D26;HTR6;HRAS;GNGT1;PLCB4;PLA2G4D;SLC18A2;CYP4X1;ITPR1
GABAergic synapsePRKACB;GABRG1;SLC38A1;GABARAP;GAD1;GABRE;GNB1;GNG11;GABRQ
Dopaminergic synapsePLCB3;DRD1;PRKACG;SLC6A3;GNG12;GRIA1;DRD1A;PPP2CA;GNG5
Olfactory transductionCNGA4;PRKACA;CALM2;OR51E2;OR5B2;OR6B2;OLFR146;ADRBK2;OR2A4
Taste transductionTAS2R103;TAS2R108;TAS2R120;TAS2R109;PRKACB;TAS2R113;SCNN1B;TAS2R137;TAS2R104
Inflammatory mediator regulation of TRP channelsMAPK12;PLCG1;PRKCB;ITPR3;CAMK2A;CYP2C70;TRPV4;MAP2K3;BDKRB1
Insulin signaling pathwayMAPK9;ARAF;CALM1A;CALM2A;PPP1R3C;SOCS4;PHKG1;PRKAR1A;TSC1A
Insulin secretionATP1B2;SLC2A2;KCNN1;ATF4;KCNMB2;Adcy4;FXYD2;CCKAR;VAMP2
GnRH signaling pathwayCALM1B;PRKACBB;ELK1;MAPK7;CALM2A;CALM3B;ITPR1;ADCY1B;LHBETA1
Ovarian steroidogenesisHSD17B7;STAR;IGF1R;INS;LHB;CYP2J5;AKR1C3;Adcy4;GNAS
Progesterone-mediated oocyte maturationCDC16;CCNA2;IGF1RA;IGF1RB;PIK3R3A;IGF1R;RPS6KAL;ANAPC2;GNAI2B
Estrogen signaling pathwaySOS1;CALM3;ATF4;ESR1;ITPR3;AKT1;PIK3CB;Adcy4;HSPA8
MelanogenesisTCF7;CALM3;WNT11;PRKACBB;WNT16;WNT10B;GNAI2A;FZD2;KIT
Thyroid hormone synthesisLRP2;DUOX2;GNAS;GPX8;GPX5;PDIA4;ATP1B4;PRKACG;ATP1B2
Thyroid hormone signaling pathwayPIK3R3;HDAC2;DIO3;ESR1;PLCG2;ITGB3;FXYD2;PIK3R2;RCAN2
Oxytocin signaling pathwayFOS;RHOA;NPR1;CACNG1;MAP2K1;CAMK2D;PPP1R12B;PIK3CA;CALM4
Regulation of lipolysis in adipocytesPTGS2;TSHB;GNAI2;GNAI1;AQP7;PIK3CB;PIK3R5;Adcy4;IRS2
Renin secretionPLCB1;GNAI2;LOC100328615;GNAS;CALM2;GUCY1B3;PRKACB;PLCB2;Ren1
Aldosterone synthesis and secretionCREB5;CREB3L3;CALM3;CYP11B2;PRKD1;CAMK1G;CALM4;GNA11;AGTR1
Endocrine and other factor-regulated calcium reabsorptionPLCB3;ATP1B2;PRKCA;CALB1;GNAS;ATP1B4;ATP1A4;DNM3;RAB11A
Salivary secretionATP1B2;CST1;RYR3;PRH1;CST2;ATP1A4;PLCB4;LYZ2;PRKACA
Gastric acid secretionATP1B2;PRKCA;PLCB1;CALML3;CALML5;HRH2;ATP1B4;ITPR3;EZR
Bile secretionOSTB;GNAS;Car2;ABCB11;BAAT;ATP1B2;EPHX1;ABCC2;LDLR
Parkinsons diseaseNDUFS7;NDUFA6;SLC25A6;COX7A1;NDUFV1;GPR37;SLC25A5;SDHC;NDUFB10
Prion diseasesMAP2K2;C8B;PRNP;HSPA5;C8G;IL6;NCAM2;BAX;ELK1
Cocaine addictionBDNF;GRIN3A;GRM3;DRD1A;MAOB;DRD1;PRKACB;CREB3L4;RGS9
AlcoholismGNG10;HDAC1;H2AFZ;HIST1H2BL;HIST2H2BE;ATF6B;CREB3L2;HIST1H2AC;HIST1H2BQ
Vibrio cholerae infectionKDELR1;ATP6V1C1;PRKCA;ATP6AP1;ACTB;ERO1L;KDELR2;ATP6V0B;ATP6V1E1
AmoebiasisLAMC1;IL10;COL4A4;SERPINB3;ADCY1;CD14;TGFB2;RAB5B;HSPB1
HTLV-I infectionETS2;HLA-DRB1;MYB;TRP53;Pdgfa&Pdgfb;BAX;DVL2;WNT7B;GSK3B
Epstein-Barr virus infectionPOLR2L;AKT1;HLA-DQB1;NFKB2;POLR2C;TRAF1;PIK3CB;MAP2K4;ENTPD8
Pathways in cancerFGFR3;PIK3CB;RAF1;FGF5;EP300;RAC3;GNG5;TGFA;RET
Viral carcinogenesisHLA-E;HIST2H4;HNRNPK;BAK1;ATP6V0D2;GTF2H2;KAT2B;TRAF2;GTF2A2
Proteoglycans in cancerBRAF;WNT4;NRAS;ROCK1;CAV1;IGF2;SMAD2;HOXD10;WNT5A
Dilated cardiomyopathyMYL2;SGCB;CACNG8;ITGA1;SGCA;ITGAV;TGFB2;ITGA9;PRKACA

PRKACA has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACA itself. We selected most functions PRKACA had, and list some proteins which have the same functions with PRKACA. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPRKCG;ABCG2B;ITPKA;STK25A;AAK1;FKBP4;IRAK1;HSPA12A;UBE2NA
cAMP-dependent protein kinase activityPRKX;PRKACA;PRKACG;PRKAA1;PRKAG1;PRKACB;AKAP13
protein bindingZNF180;OTUD7B;TERF2;MLPH;MLANA;OLFM2;HCLS1;ZNHIT3;CAPG
protein complex bindingFYB;KRT8;KHDRBS1;MTAP1B;ITGB1BP1;UQCRC2;HCLS1;TRAF2;CRHR1
protein kinase A regulatory subunit bindingARFGEF1;KCNQ1;RYR2;AKAP5;ARFGEF2;ACBD3;AKAP1;AKAP7;AKAP6
protein kinase bindingMAP2K7;MVP;KIF13B;STXBP1;TRP53;SPDYE2;CACNB4;GHR;KIF20A
protein serine/threonine/tyrosine kinase activityAKT1;ACVR2B;AURKB;AURKA;RPS6KA2;PRKACA;RPS6KA1;TESK2;TESK1
ubiquitin protein ligase bindingCCDC50;GPR19;CUL4A;PCBP2;UBE2T;UBE2K;MAGEA2B;BRCA1;DIO2

PRKACA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACA here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACA.

PRKAR1A; PRKAR2B; GSK3B; PRKAR2A; PRKAR1B; LRRK2

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