prlr
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  • Official Full Name
  • prolactin receptor
  • Background
  • This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
  • Synonyms
  • PRLR; prolactin receptor; HPRL; MFAB; hPRLrI; PRL-R; hPRL receptor; secreted prolactin binding protein;
Cat.#:PRLR-2060HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRLR Protein, His-tagged
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Cat.#:PRLR-386HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRLR Protein, Fc-tagged
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Cat.#:PRLR-720HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRLR Protein, His-tagged
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Cat.#:Prlr-721RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Prlr Protein, His-tagged
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Cat.#:PRLR-719BTag:His
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine PRLR Protein, His-tagged
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Cat.#:PRLP-3704HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRLP, GST-tagged
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Cat.#:PRLR-1677HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human Prolactin Receptor, Fc-tagged
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Cat.#:PRLR-177HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRLR, His tagged
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Cat.#:PRLR-2723HCLTag:MYC/DDK
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human PRLR HEK293T cell lysate
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Cat.#:PRLR-4144HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Prolactin Receptor
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Cat.#:PRLR-58HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Prolactin Receptor, GST-tagged
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Cat.#:PRLR-59HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PRLR protein, GST-tagged
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Cat.#:PRLR-76HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Prolactin Receptor, chiMAX Fc Fusion Protein
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Cat.#:Prlr-213MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Prlr, Fc-His tagged
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Cat.#:Prlr-7395MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Prlr, His tagged
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Cat.#:Prlr -100RTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat Prolactin Receptor, chiMAX Fc Fusion Protein
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Cat.#:Prlr-1797RTag:N/A
Source (Host):NS0Species:Rat
Product nameRecombinant Rat Prolactin Receptor
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Cat.#:PRLR-4701RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRLR Protein
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Cat.#:Prlr-62RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Prolactin Receptor
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Cat.#:Prlr-7003RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Prlr, His tagged
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Cat.#:PRLR-53BTag:N/A
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine Prolactin Receptor
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Cat.#:PRLR-1837RTag:N/A
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit Prolactin Soluble Receptor
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Cat.#:PRLR-6417CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRLR
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Cat.#:PRLR-55OTag:N/A
Source (Host):E. coliSpecies:Ovine
Product nameRecombinant Ovine Prolactin Receptor
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Cat.#:prlr-61RTag:N/A
Source (Host):E. coliSpecies:Rainbow Trout
Product nameRecombinant Rainbow Trout Prolactin Receptor
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Cat.#:PRLR-2722HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRLR cell lysate
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Cat.#:PRLR-1451MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PRLR cell lysate
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Cat.#:PRLR-1740RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat PRLR cell lysate
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Involved Pathway

Prlr involved in several pathways and played different roles in them. We selected most pathways Prlr participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prlr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL4R; CCR8; CXCR4A; RELT; XCR1; IFNE; ACVR1; INHBE; IL9; PDGFB
Neuroactive ligand-receptor interaction
GRIK3; PTGER4; RXFP4; F2RL3; MTNR1BB; HTR1B; ADRB2A; DRD7; GIPR; GRIA4
PIK-Akt signaling pathway
KIT; GNG13; IL7R; PDPK1; IL4; IFNA21; IL3RA; GNG8; G6PC3; FGF4
Jak-STAT signaling pathway
Il23a; Il12b; IL22; IL7R; IL3; IL2RA; STAT3; SOCS1A; MTOR; PIK3R3A; IL19
Prolactin signaling pathway
TH; SHC1; SOCS1; SOCS3; MAPK1; GSK3B; SHC3; LHCGR; SRC; MAPK12

Protein Function

Prlr has several biochemical functions, for example, metal ion binding, ornithine decarboxylase activator activity, peptide hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Prlr itself. We selected most functions Prlr had, and list some proteins which have the same functions with Prlr. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein SAP30L; ZNFX1; SMAD2; PLA2G4D; ZFAND5B; CSGALNACT2; PPM1L; SMYD2A; TGM2A; GNAI1
Function ornithine decarboxylase activator activity
Related Protein PRLR; AZIN2; AZIN1A; AZIN1; AZIN1B
Function peptide hormone binding
Related Protein HCRTR2; MC4R; PRLR; PTH1RA; PTH1RB; GHRHR; AGTR1B; RXFP2; INHBA; GALR3
Function prolactin receptor activity
Related Protein PRLR
Function protein binding
Related Protein SOX9A; KLHDC5; SLC39A7; PARP2; SUMO1; INTS4; ACAA2; SARM1; ZNF622; NEU4
Function protein homodimerization activity
Related Protein SLC14A2; PVRL1B; SDCBP2; MCL1; S100A6; CRYAB; ADH5; UGT1A3; MAOB; MTMR2

Interacting Protein

Prlr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prlr here. Most of them are supplied by our site. Hope this information will be useful for your research of Prlr.
GH1; NEK3; VAV2; YWHAZ

Prlr Related Articles

Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
Sackmann-Sala, L; Goffin, V; et al. Prolactin-Induced Prostate Tumorigenesis. RECENT ADVANCES IN PROLACTIN RESEARCH 846:221-242(2015).