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PROM1

  • Official Full Name

    prominin 1

  • Overview

    CD133 (also known as Prominin-1 or AC133) is a 120 kD pentaspan glycoprotein with 5 transmembrane domains which localize to cellular protrusions. CD133 was initially described as a surface antigen specific for human hematopoietic stem cells and as a marke
  • Synonyms

    PROM1; prominin 1; prominin-1; prominin-like 1; antigen AC133 homolog; prominin-like protein 1; Prom; AC133; CD133; Prom-1; Proml1; 4932416E19Rik;

  • Recombinant Proteins
  • Chromatography Reagents
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Myc
  • DDK
  • DYKDDDDK
  • Fc
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • SUMO
  • Myc|DDK
  • N/A
  • N
  • mFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PROM1-095H Active Recombinant Human PROM1 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human PROM1-456H Active Recombinant Human PROM1 protein, His-Avi-tagged, Biotinylated(Detergent) HEK293 His-Avi Gly 20 - His 865
Human PROM1-5907H Active Recombinant Human PROM1 protein, His-tagged(Detergent) HEK293 His Gly 20 - His 865
Human PROM1-3572H Active Recombinant Human PROM1 protein, His-tagged(Nanodisc) HEK293 His Gly 20 - His 865
Human PROM1-3972H Active Recombinant Human PROM1 protein, His-Avi-tagged, Biotinylated(Nanodisc) HEK293 His-Avi Gly 20 - His 865
Human PROM1-712H Active Recombinant Human PROM1 Full Length Transmembrane protein(VLPs) HEK293 N/A Gly 20 - His 865
Human PROM1-46H Recombinant Human PROM1, MYC/DDK-tagged HEK293 Myc/DDK
Human PROM1-7072H Recombinant Human PROM1 protein, His-tagged E.coli His Ile171~Asp431
Human PROM1-73H Recombinant Human Prominin 1, GST-tagged Wheat Germ GST
Human PROM1-70H Recombinant Human Prominin 1 Wheat Germ N/A
Human PROM1-45H Recombinant Human PROM1, MYC/DDK-tagged HEK293 Myc/DDK
Human CD133-90H Recombinant Human Prominin 1, GST-tagged Wheat Germ GST
Human PROM1-1380H Recombinant Human PROM1 Protein (Ala179-Tyr433), N-His tagged E.coli N-His Ala179-Tyr433
Human PROM1-1493H Recombinant Human PROM1 Protein (508-792 aa), His-tagged Yeast His 508-792 aa
Human PROM1-412H Recombinant Human PROM1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human PROM1-954H Recombinant Human PROM1 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human PROM1-247H Recombinant Human PROM1 protein, hFc-tagged HEK293 hFc Gly20-Gly108
Human PROM1-5259H Recombinant Human PROM1 Protein (Ser279-Gly390), C-His tagged Mammalian cells C-His Ser279-Gly390
Human PROM1-1728H Recombinant Human PROM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PROM1-399HF Recombinant Full Length Human PROM1 Protein In Vitro Cell Free System 865 amino acids
Human PROM1-953H Recombinant Human PROM1 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human PROM1-7929HFL Recombinant Full Length Human PROM1, Flag-tagged Mamanlian cells Flag
Human PROM1-1893H Active Recombinant Human PROM1 Full Length Transmembrane protein, His-tagged HEK293 His 20-865aa
Human PROM1-161H Recombinant Human PROM1 Protein, C-His-tagged E.coli C-His
Human PROM1-2795H Recombinant Human PROM1 Protein (Gly508-Asn792), His tagged E.coli His Gly508-Asn792
Human PROM1-327H Recombinant Human PROM1 protein, His-tagged HEK293 His Gly20-Gly108
Human PROM1-1381H Recombinant Human PROM1 Protein (Leu805-Ans865), N-GST tagged E.coli N-GST Leu805-Ans865
Mouse Prom1-7073M Recombinant Mouse Prom1 protein, His-tagged E.coli His Ala180~Trp435
Mouse PROM1-503M PROM1 Antibody-coupled magnetic MicroBeads
Mouse Prom1-3371M Recombinant Mouse Prom1 protein, His-SUMO-tagged E.coli His-SUMO 509-794aa
Mouse Prom1-5140M Recombinant Mouse Prom1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Prom1-121R Recombinant Rat Prom1, His-tagged Human Cell His
Rat PROM1-166R Recombinant Rat Prom1, Fc tagged Human Cell His
Rat Prom1-120R Recombinant Rat Prom1 protein(Asn171-Tyr424), mFc-tagged HEK293 N-mFc Asn171-Tyr424
Rat Prom1-33R Recombinant Rat Prom1, His tagged Human Cell His
Rat PROM1-981RCL Recombinant Rat PROM1 cell lysate Human Cell N/A
Rat Prom1-120RA Recombinant Rat Prom1 protein, Fc-tagged, APC labeled HEK293 Fc
Rat Prom1-120RP Recombinant Rat Prom1 protein, Fc-tagged, R-PE labeled HEK293 Fc
Rat Prom1-120RAF488 Recombinant Rat Prom1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 490
Rat Prom1-120RAF555 Recombinant Rat Prom1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 490
Rat Prom1-120RAF647 Recombinant Rat Prom1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 490
Rat Prom1-120RF Recombinant Rat Prom1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 490
Rhesus Macaque PROM1-3619R Recombinant Rhesus monkey PROM1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PROM1-3437R-B Recombinant Rhesus Macaque PROM1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PROM1-3437R Recombinant Rhesus Macaque PROM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken PROM1-5497C Recombinant Chicken PROM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PROM1 Related Articles
  • PROM1 Related Research Area

PROM1 involved in several pathways and played different roles in them. We selected most pathways PROM1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PROM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Transcriptional misregulation in cancerTRAF1;CEBPE;BMI1;GOLPH3L;KDM6A;Bcl2a1b;TSPAN7;MAX;PBX1

PROM1 has several biochemical functions, for example, actinin binding, cadherin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PROM1 itself. We selected most functions PROM1 had, and list some proteins which have the same functions with PROM1. You can find most of the proteins on our site.

Function Related Protein
actinin bindingCSRP3;RELA;TTN;NFKB1;MICALL2;PKD2;PROM1;PDLIM5
cadherin bindingFert2;PSEN1;CTNND1;AKAP5;MMP24;CD2AP;JUPA;CDK5R1;CTNNA3
protein bindingSOX4;KCNMB4;NAT9;RPIA;S100A9;SPANXA1;IGF2BP1;MRFAP1L1;AJUBA

PROM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PROM1.

ACTB; Actb; Cdhr1; PLEKHA5

Olausson, KH; Maire, CL; et al. Prominin-1 (CD133) Defines Both Stem and Non-Stem Cell Populations in CNS Development and Gliomas. PLOS ONE 9:-(2014).
Gopisetty, G; Xu, J; et al. Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylation. ONCOGENE 32:3119-3129(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there specific diseases where PROM1 protein is extensively studied? 01/25/2022

Yes, PROM1's role is widely studied in various cancers, including brain, breast, colon, and pancreatic cancers.

What methods are used to study PROM1 protein in clinical settings? 10/24/2021

Various laboratory techniques, such as flow cytometry, immunohistochemistry, and molecular biology assays, are employed to study PROM1 expression and function.

Is PROM1 exclusively related to cancer and regenerative medicine? 01/05/2019

No, PROM1 is also associated with certain eye disorders and is being researched for potential applications in retinal diseases.

Can PROM1 be a potential target for therapeutic interventions? 08/10/2016

Research suggests that it could be a target for treatments aimed at eliminating cancer stem cells and potentially preventing cancer relapse.

Are there any side effects associated with targeting PROM1 in therapies? 03/06/2016

The potential impact on normal stem cells and unintended consequences on healthy tissues are areas of concern when targeting PROM1 for therapies.

Customer Reviews (3)

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Reviews
05/01/2021

    They can offer detailed characterization data, including purity, stability, and functional assessments, to support researchers' confidence in using the protein in their trials.

    10/01/2017

      Manufacturers can support researchers in developing assays to measure PROM1 protein levels or activity specific to their clinical trial settings.

      12/14/2016

        This may involve guidance in selecting appropriate detection methods, providing assay components, or optimizing protocols for optimal performance and sensitivity.

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