PRSS1
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Official Full Name
protease, serine, 1 (trypsin 1)
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Overview
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. -
Synonyms
PRSS1; protease, serine, 1 (trypsin 1); TRY1; trypsin-1; Alpha-trypsin chain 2; Beta-trypsin; Cationic trypsinogen; Serine protease 1; TRY1_HUMAN; Trypsin I; trypsinogen 1; trypsinogen A; digestive zymogen; nonfunctional trypsin 1; TRP1; TRY4; TRYP1;
- Recombinant Proteins
- Native Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.Coli or Yeast
- HEK293
- Human Pancreas
- Mammalian Cell
- Mammalian cells
- Yeast
- C
- His
- Fc
- Fc|His
- His (Fc)
- Avi
- Myc
- His|SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PRSS1 Related Research Area
PRSS1 involved in several pathways and played different roles in them. We selected most pathways PRSS1 participated on our site, such as Neuroactive ligand-receptor interaction, Pancreatic secretion, Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRSS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | PTGER4;TAAR14E;LOC780933;PTH1RB;LOC100328615;TAAR7B;THRA;GABRA5;CHRNB1 |
| Pancreatic secretion | PLA2G3;LOC780933;CPB2;PLCB4;CLCA4;PNLIP;CTRL;ATP1B2;TRPC1 |
| Protein digestion and absorption | ATP1B3;CELA2B;ATP1A3;KCNE3;SLC3A1;ATP1A4;ATP1B2;PRSS1;ATP1A2 |
| Influenza A | STAT1;IFNA8;KPNA2;NLRP3;CASP1;TNFSF10;Fasl;MYD88;MAVS |
PRSS1 has several biochemical functions, for example, metal ion binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRSS1 itself. We selected most functions PRSS1 had, and list some proteins which have the same functions with PRSS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZNF821;JUB;PVALB8;ZFP276;SH3RF3;CPEB1B;ZNF671;HIC1L;FHL1B |
| serine-type endopeptidase activity | PRSS3;PRSS7;HTRA3;GZMH;HTRA1;PROCA;MASP2;CELA2A;FURINB |
PRSS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRSS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRSS1.
GRB2; ALB; PPP2R2B; STK38L
- Q&As
- Reviews
Q&As (6)
Ask a questionThe structure of PRSS1 determines its ability to bind specifically to the substrate and the efficiency of the catalytic reaction. The study of its structure can help us understand its function and mechanism of action.
PRSS1 can interact with other digestive enzymes, such as stomach acid and bile, to participate in the digestive process of food.
It is primarily involved in the digestion of proteins in the digestive system, breaking them down into small peptides and amino acids.
Therapeutic strategies for PRSS1 may include supplementing or inhibiting its expression and regulating its interaction with other digestive enzymes. These methods may have potential applications in treating diseases such as pancreatitis or pancreatic cancer.
The expression of PRSS1 in the pancreas is determined by factors such as its substrate specificity and synergies with other digestive enzymes. In other organs, its expression may vary by different regulatory mechanisms.
Lack of PRSS1 may lead to protein digestion disorders, while overexpression of PRSS1 may lead to diseases such as pancreatitis or pancreatic cancer.
Customer Reviews (3)
Write a reviewThe pharmacodynamic parameters of PRSS1 were good.
PRSS1 has very high sensitivity in Western blot and can detect low concentrations of the protein of interest.
PRSS1 has good compatibility and stability with various excipients.
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