PSME1
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Official Full Name
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
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Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified. -
Synonyms
PSME1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); proteasome activator complex subunit 1; IFI5111; PA28alpha; 11S regulator complex alpha subunit; 29kD MCP activator subunit; Activator of multicatalytic protease subunit 1; Interferon gamma IEF SSP 5111; Interferon gamma inducible protein 5111; Interferon gamma up regulated I 5111 protein; MGC8628; PA28A; Proteasome activator subunit 1; REGalpha; REG-alpha; IGUP I-5111; 29-kD MCP activator subunit; interferon-gamma IEF SSP 5111; proteasome activator subunit-1; 11S regulator complex subunit alpha; proteasome activator 28 subunit alpha; interferon-gamma-inducible protein 5111; interferon gamma up-regulated I-5111 protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PSME1 involved in several pathways and played different roles in them. We selected most pathways PSME1 participated on our site, such as Proteasome, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSME1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMD11B;PSMB9B;PSMA4;SHFM1;PSMD6;PSMA2;PSMD11;PSMB7;POMP |
| Antigen processing and presentation | CD8B;CD8A;KLRC1;HLA-A;H2-AB1;HSPA5;NFYA;HSPA6;HLA-C |
PSME1 has several biochemical functions, for example, endopeptidase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSME1 itself. We selected most functions PSME1 had, and list some proteins which have the same functions with PSME1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activator activity | PSMD14;PSME1;ADRM1;PSME2;SFRP2;PSME3 |
PSME1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSME1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSME1.
PFDN1; RPP14; TK1; ATP1B1; VIM; VCL; CHD3; AIMP2; ITGB3BP; TUBB2A; SETDB1; CDC37; SMN1; leuD; PIK3R3; EMG1; PSME2; USP22
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