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PSPN

  • Official Full Name

    persephin

  • Overview

    The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo.
  • Synonyms

    PSPN; persephin; PSP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PSPN-1003H Active Recombinant Human PSPN E.coli N/A Ala61-Gly156
Human PSPN-570H Recombinant Human PSPN protein E.coli N/A 96
Human PSPN-2733HCL Recombinant Human PSPN 293 Cell Lysate HEK293 N/A
Human PSPN-231H Active Recombinant Human PSPN Protein E.coli
Human PSPN-361H Recombinant Human PSPN Protein, His/GST-tagged E.coli His/GST Val29~Gly156
Human PSPN-6006H Recombinant Human PSPN Protein (Ala61-Gly156), N-His tagged E.coli N-His Ala61-Gly156
Human PSPN-098H Active Recombinant Human PSPN Protein E. coli
Mouse Pspn-1010M Active Recombinant Mouse Pspn E.coli N/A Ala61-Gly156
Mouse Pspn-5209M Active Recombinant Mouse Pspn Protein E. coli
Mouse Pspn-21M Recombinant Mouse Pspn protein E.coli N/A 96
Rat PSPN-4793R Recombinant Rat PSPN Protein Mammalian Cell His
Rat PSPN-4452R Recombinant Rat PSPN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PSPN-4452R-B Recombinant Rat PSPN Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PSPN Related Research Area

PSPN involved in several pathways and played different roles in them. We selected most pathways PSPN participated on our site, such as Axon guidance, Developmental Biology, NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceEFNA1A;SRGAP2;ITGB3A;DUSP5;PAK3;NRAS;SEMA3D;EFNA1;EFNA3
Developmental BiologyACVR1C;PLXND1;RGMA;DPYSL3;DRAP1;DCX;COL9A1A;COL6A3;DUSP5
NCAM signaling for neurite out-growthPSPN;COL9A1A;GFRA1;GFRA2;COL9A1B;GDNF;ST8SIA2;NRTN;GFRA4
NCAM1 interactionsGFRA1;NRTN;PSPN;GFRA4;GFRA2;COL9A1B;COL9A1A;GDNF

PSPN has several biochemical functions, for example, growth factor activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSPN itself. We selected most functions PSPN had, and list some proteins which have the same functions with PSPN. You can find most of the proteins on our site.

Function Related Protein
growth factor activityCSF1A;NRG3;FGF10B;IL3;AREG;BMP15;FGF3;EREG;TGFB1
receptor bindingPTK6B;C5;TNFSF8;DVL3;HAND2;PTK2B;NXPH1;CTNND1;PLXNC1

PSPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSPN here. Most of them are supplied by our site. Hope this information will be useful for your research of PSPN.

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