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PTGES

  • Official Full Name

    prostaglandin E synthase

  • Overview

    Prostaglandin E synthase-1 (PGE synthase-1) catalyzes the isomerization of PGH2 to PGE2. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. PGE synthase-1 is a 16 kDa membrane associated protein with glutathione-dependent activity. The mRNA for PGE synthase-1 is expressed in a variety of tissues including prostate, testes, and small intestine as well as in A549 and HeLa cells. PGE synthase-1 protein expression is increased in A549 cells following treatment with IL-1β.
  • Synonyms

    PTGES; prostaglandin E synthase; MGST1L1; glutathione S transferase 1 like 1; MGST IV; MGST1 L1; MGST1 like 1; microsomal glutathione S transferase 1 like 1; microsomal prostaglandin E synthase 1; p53 induced gene 12; PIG12; TP53I12; tumor protein p53 ind;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Equus caballus (Horse)
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In vitro E. coli expression system
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf21 Insect Cell
  • C
  • 10×His
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|GST
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTGES-583H Recombinant Human Prostaglandin E Synthase Sf21 Insect Cell N/A
Human PTGES-32H Recombinant Human PTGES protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PTGES-145H Recombinant Human PTGES Protein, His/GST-tagged E.coli His/GST Thr21~Ala148
Human PTGES-2715HCL Recombinant Human PTGES 293 Cell Lysate HEK293 N/A
Human PTGES-1544H Recombinant Human PTGES Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTGES-9439HFL Recombinant Full Length Human PTGES protein, Flag-tagged Mamanlian cells Flag
Human PTGES-3312H Recombinant Human PTGES Protein (Met1-Leu152), His tagged E.coli His Met1-Leu152
Human PTGES-11H Recombinant Human PTGES-3C-eGFP Protein (M1-L152 end), C-10×His-tagged Insect Cell C-10×His M1-L152 end
Human PTGES-1247H Recombinant Human PTGES Protein (M1-L152 end), His tagged Insect Cell His M1-L152 end
Mouse Ptges-483M Recombinant Mouse Ptges Full Length Transmembrane protein, His-SUMO-tagged In vitro E. coli expression system His-SUMO 1-153aa
Mouse Ptges-5220M Recombinant Mouse Ptges Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Ptges-1999R Recombinant Rat Ptges Protein, His-tagged E.coli N-His Thr35-Tyr131
Bos taurus (Bovine) RFL23092BF Recombinant Full Length Bovine Prostaglandin E Synthase(Ptges) Protein, His-Tagged E.coli expression system His Full Length (1-153)
Canis lupus familiaris (Dog) (Canis familiaris) RFL22685CF Recombinant Full Length Dog Prostaglandin E Synthase(Ptges) Protein, His-Tagged E.coli expression system His Full Length (1-153)
Equus caballus (Horse) RFL6531EF Recombinant Full Length Horse Prostaglandin E Synthase(Ptges) Protein, His-Tagged E.coli expression system His Full Length (1-153)
Homo sapiens (Human) RFL35415HF Recombinant Full Length Human Prostaglandin E Synthase(Ptges) Protein, His-Tagged E.coli expression system His Full Length (1-152)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL16895MF Recombinant Full Length Macaca Fascicularis Prostaglandin E Synthase(Ptges) Protein, His-Tagged E.coli expression system His Full Length (1-152)
Mus musculus (Mouse) RFL27653MF Recombinant Full Length Mouse Prostaglandin E Synthase(Ptges) Protein, His-Tagged E.coli expression system His Full Length (1-153)
Rhesus Macaque PTGES-3691R Recombinant Rhesus monkey PTGES Protein, His-tagged Mammalian Cell His
Rhesus Macaque PTGES-3509R-B Recombinant Rhesus Macaque PTGES Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PTGES-3509R Recombinant Rhesus Macaque PTGES Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PTGES-2298Z Recombinant Zebrafish PTGES Mammalian Cell His
Chicken PTGES-4126C Recombinant Chicken PTGES Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTGES Related Articles

PTGES involved in several pathways and played different roles in them. We selected most pathways PTGES participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismPTGS2A;AWAT1;CYP2C38;CBR1L;GGT1A;CYP2C9;CYP2U1;CYP4A10;CYP2C50
Metabolic pathwaysATP6V1C1B;AGL;DPM2;POLR1D;NNT;INPP5KA;BPGM;CYP27B1;FBP2

PTGES has several biochemical functions, for example, glutathione binding, prostaglandin-E synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGES itself. We selected most functions PTGES had, and list some proteins which have the same functions with PTGES. You can find most of the proteins on our site.

Function Related Protein
glutathione bindingGSTM1;PTGES2;GSTM2;GSTM4;GSTP2;GPX1;PTGESL;GSTM7;GSTM3
prostaglandin-E synthase activityPTGES;PTGES3;PTGESL;PTGES2

PTGES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGES here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGES.

GOLT1B

Reddy, SA; Shelar, SB; et al. Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-kappa B- and MAPK-dependent manner. INTERNATIONAL IMMUNOPHARMACOLOGY 24:440-450(2015).
Gobel, C; Breitenbuecher, F; et al. Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity. CELL DEATH & DISEASE 5:-(2014).
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