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PTN

  • Official Full Name

    pleiotrophin

  • Overview

    Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene.Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein.
  • Synonyms

    PTN; pleiotrophin; NEGF1, neurite growth promoting factor 1; HBGF8; HBNF; heparin binding growth factor 8; HBBM; OSF-1; HB-GAM; HBGF-8; HBNF-1; osteoblast-specific factor 1; heparin-binding brain mitogen; heparin-binding growth factor 8; heparin affin re;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • Human Cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21 Insect Cell
  • C
  • His
  • Fc
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTN-630H Active Recombinant Human PTN protein E.coli N/A
Human PTN-30875TH Recombinant Human PTN, His-tagged E.coli His
Human PTN-30874TH Recombinant Human PTN protein E.coli N/A 136
Human PTN-672H Recombinant Human PTN Protein E.coli N/A
Human PTN-343H Recombinant Human Pleiotrophin Sf21 Insect Cell N/A
Human PTN-3694H Recombinant Human PTN, His-tagtged E.coli His
Human PTN-131H Recombinant Human Pleiotrophin, His-tagged E.coli His
Human PTN-8529H Recombinant Human PTN, None tagged Insect Cell His
Human PTN-439H Recombinant Human PTN protein, His-tagged HEK293F His Gly33~Asp168
Human PTN-673H Recombinant Human PTN Protein, GST-His-tagged E.coli GST/His
Human PTN-001HCL Recombinant Human PTN cell lysate Insect Cell N/A
Human PTN-261H Recombinant Human PTN Protein (Gly33-Asp168), C-His tagged, Animal-free, Carrier-free E.coli C-His Gly33-Asp168
Human PTN-0304H Active Recombinant Human PTN protein Insect Cells N/A Met1-Asp168
Human PTN-232H Recombinant Human PTN Protein E.coli
Human PTN-301230H Recombinant Human PTN protein, GST-tagged E.coli GST Gln94-Asp168
Human PTN-6088H Active Recombinant Human PTN Protein(Gly33~Asp168), His-tagged E. coli N-His Gly33~Asp168
Human PTN-0632H Recombinant Human PTN protein, His-tagged HEK293 His Gly33-Asp168
Mouse PTN-1034M Recombinant Mouse PTN protein(Met1-Asp168) Insect Cells N/A Met1-Asp168
Mouse Ptn-6790M Recombinant Mouse Ptn protein, His-tagged E.coli His Gly33~Asp168 (Accession # P63089)
Mouse Ptn-7414M Recombinant Mouse Ptn, Fc tagged Human Cell Fc
Mouse PTN-386M Recombinant Mouse Ptn, None tagged Insect Cell His
Mouse PTN-001MCL Recombinant Mouse PTN cell lysate Insect Cell N/A
Mouse PTN-1524MCL Recombinant Mouse PTN cell lysate Human Cell N/A
Rat PTN-4825R Recombinant Rat PTN Protein Mammalian Cell His
Rat PTN-4484R-B Recombinant Rat PTN Protein Pre-coupled Magnetic Beads HEK293
Rat Ptn-2001R Recombinant Rat Ptn Protein, His-tagged E.coli N-His Gly33-Asp168
Rat PTN-4484R Recombinant Rat PTN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle PTN-6789C Recombinant Cattle PTN protein, His-tagged E.coli His Gly33~Asp168 (Accession # P21782)
Rhesus Macaque PTN-3697R Recombinant Rhesus monkey PTN Protein, His-tagged Mammalian Cell His
Rhesus Macaque PTN-3514R Recombinant Rhesus Macaque PTN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PTN-3514R-B Recombinant Rhesus Macaque PTN Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PTN-1180Z Recombinant Zebrafish PTN Mammalian Cell His
Chicken PTN-4710C Recombinant Chicken PTN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTN Related Articles
  • PTN Related Research Area

PTN involved in several pathways and played different roles in them. We selected most pathways PTN participated on our site, such as Syndecan-3-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Syndecan-3-mediated signaling eventsCOL20A1;PTN;AGRP

PTN has several biochemical functions, for example, chondroitin sulfate proteoglycan binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTN itself. We selected most functions PTN had, and list some proteins which have the same functions with PTN. You can find most of the proteins on our site.

Function Related Protein
chondroitin sulfate proteoglycan bindingPTPRF;PTN;COL20A1;SEMA5A
growth factor activityCSF2;BMP7;LACRT;AMELX;RABEP1;FGF6A;TGFA;PDGFA;FGF21
heparin bindingGPNMB;FGFRL1;PTPRF;KAL1;FGF7;CXCL13;CLEC3B;CYR61L1;PGF
protein phosphatase inhibitor activityCOL20A1;PPP1R27;PHACTR1;PPP1R37;ARPP19;SET;PPP1R14D;PPP1R1C;PPP1R35

PTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTN here. Most of them are supplied by our site. Hope this information will be useful for your research of PTN.

SGTA; CHD3; TAF1D; UBQLN4; DNAJB11; SMAP; PSMD11; EIF3F; CACNB4; TXNDC9; PLXNB2; SGSM2; NUDT21; DFNA5; PFDN1

Hugosson, F; Sjogren, C; et al. The Drosophila Midkine/Pleiotrophin Homologues Miple1 and Miple2 Affect Adult Lifespan but Are Dispensable for Alk Signaling during Embryonic Gut Formation. PLOS ONE 9:-(2014).
Du, CX; Wang, L; et al. Elevated expression of pleiotrophin in lymphocytic leukemia CD19(+) B cells. APMIS 122:905-913(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is PTN involved in neurodevelopment and neuronal plasticity? 11/27/2021

 PTN plays a critical role in neurodevelopment and neuronal plasticity. During embryonic development, PTN promotes axonal outgrowth, neuronal migration, and synaptogenesis. It interacts with cell surface receptors on neurons, such as ALK, to activate downstream signaling pathways that modulate cytoskeletal dynamics and promote neurite growth. In the adult brain, PTN is involved in synaptic plasticity, memory formation, and neuronal survival. Dysregulation of PTN expression or signaling can disrupt normal neurodevelopmental processes and contribute to neurological disorders.

What are the potential diagnostic applications of PTN? 05/22/2021

 PTN has shown promise as a diagnostic biomarker for certain diseases. Increased PTN expression has been observed in the serum or tissue samples of patients with various cancers, suggesting its potential as a cancer biomarker. Additionally, PTN levels in cerebrospinal fluid have been associated with neurodegenerative disorders, including Alzheimer's disease. Ongoing research aims to develop sensitive and specific assays for PTN detection, which could aid in early disease diagnosis, prognosis, and monitoring of treatment response in these conditions.

 What are the downstream signaling pathways activated by PTN? 11/19/2017

PTN binding to its cell surface receptors initiates downstream signaling pathways that regulate cellular functions. One of the major pathways activated by PTN is the phosphoinositide 3-kinase (PI3K)/Akt pathway, which promotes cell survival and growth. PTN can also activate the mitogen-activated protein kinase (MAPK) pathway, including extracellular signal-regulated kinase (ERK), leading to cellular proliferation and differentiation. Additionally, PTN can influence intracellular calcium signaling and modulate the activity of various transcription factors, ultimately impacting gene expression and cellular behavior.

What is the biological function of the protein PTN? 08/30/2017

The protein PTN, also known as pleiotrophin, plays a crucial role in various biological processes. It functions as a cytokine and growth factor that regulates cellular proliferation, differentiation, and migration. PTN is involved in embryonic development, tissue repair, and the maintenance of neuronal plasticity. Its interactions with cell surface receptors, such as receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and anaplastic lymphoma kinase (ALK), mediate downstream signaling cascades that influence cellular behavior and tissue homeostasis.

Are there any diseases associated with dysregulation of PTN expression? 05/31/2017

Dysregulation of PTN expression has been implicated in several diseases. Increased PTN levels have been observed in various types of cancer, including breast, lung, and glioblastoma, where it promotes tumor growth, angiogenesis, and metastasis. Furthermore, aberrant PTN expression has been linked to neurodegenerative disorders, such as Alzheimer's disease, where it contributes to neuronal dysfunction and neuroinflammation. In cardiovascular diseases, PTN can promote vascular smooth muscle cell proliferation and contribute to the development of atherosclerosis.

How is the PTN protein regulated at the transcriptional level? 03/21/2017

The transcriptional regulation of the PTN gene involves complex mechanisms. Several transcription factors, including AP-1, NF-κB, and SP1, have been identified as regulators of PTN expression. Additionally, epigenetic modifications, such as DNA methylation and histone acetylation, can modulate PTN gene activity. Furthermore, various extracellular stimuli, including growth factors and cytokines, can induce PTN expression through the activation of specific signaling pathways, such as the MAPK/ERK and PI3K/Akt pathways.

What therapeutic strategies are being explored to target PTN? 04/10/2016

 Inhibition of PTN activity or downstream effectors is being investigated as a potential therapeutic approach. Small molecule inhibitors and monoclonal antibodies targeting PTN or its receptors are being developed to block PTN signaling and mitigate its pathological effects. Additionally, strategies to modulate PTN expression through gene therapy or targeted delivery of RNA-based therapeutics are being explored. The efficacy of these approaches is being evaluated in preclinical and clinical studies to determine their potential for treating PTN-related diseases.

Customer Reviews (3)

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Reviews
08/29/2022

    By utilizing this experimental reagent, I save a significant amount of time and effort, enabling a seamless workflow.

    06/30/2020

      Using this reagent, I can rapidly obtain high-quality experimental data.

      07/30/2018

        Following the implementation of this protein reagent, the reproducibility of my experiments has significantly improved, leaving me highly satisfied.

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