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PTPN13

  • Official Full Name

    protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)

  • Overview

    A novel protein tyrosine phosphatase, FAP-1 (for FAS-associated phosphatase) (originally designated PTP-BAS), has been shown to associated with the carboxy terminus fifteen amino acids of FAS. Three isoforms of the protein result from alternative RNA splicings, the longest of which encodes a protein 2485 amino aicds in lenghth. Although lacking a transmembrane region, FAP-1 does contain a membrane-binding domain, similar to that found in cytoskeleton-associated proteins such as ezrin. FAP-1 does not seem to associate with CD40 or death domain proteins such as TNF-RI and TNF-RII.
  • Synonyms

    PTPN13; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); tyrosine-protein phosphatase non-receptor type 13; PTP BAS; PTP BL; PTP1E; PTPL1; hPTPE1; protein-tyrosine phosphatase 1E; protein-tyrosine phosphatase PTPL1; fas-associated protein-tyrosine phosphatase 1; PNP1; FAP-1; PTPLE; PTP-BL; hPTP1E; PTP-BAS; DKFZp686J1497;

  • Recombinant Proteins
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • GST
  • His
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTPN13-463H Recombinant Human PTPN13,GST-tagged,Active E.coli GST
Human PTPN13-8097H Recombinant Human PTPN13 protein, His & T7-tagged E.coli His/T7 Met1~Asn161 (Accession # Q12923)
Human PTPN13-3728H Recombinant Human PTPN13 protein, His-tagged E.coli His 1-350 aa
Mouse Ptpn13-337M Active Recombinant Mouse Protein Tyrosine Phosphatase, Non-receptor Type 13 E.coli N/A
Mouse Ptpn13-8098M Recombinant Mouse Ptpn13 protein, His & T7-tagged E.coli His/T7 Met1~Asn161 (Accession # G5E8B1)
Rat Ptpn13-8099R Recombinant Rat Ptpn13 protein, His & T7-tagged E.coli His/T7 Met1~Asn161 (Accession # G3V9S3)
Zebrafish PTPN13-5628Z Recombinant Zebrafish PTPN13 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTPN13 Related Research Area
  • PTPN13 Related Signal Pathway

PTPN13 involved in several pathways and played different roles in them. We selected most pathways PTPN13 participated on our site, such as Apoptosis Modulation and Signaling, Ephrin B reverse signaling, Fc-epsilon receptor I signaling in mast cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Apoptosis Modulation and SignalingDIABLO;DFFA;BLK;HRK;HN1;CASP2;PTRH2;CDKN2A;BCL2L11
Ephrin B reverse signalingEFNB1;EFNB2;PTPN13
Fc-epsilon receptor I signaling in mast cellsLAT2;DOK1;S1PR1;PTPN13;ITK

PTPN13 has several biochemical functions, for example, phosphatidylinositol 3-kinase regulatory subunit binding, protein binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN13 itself. We selected most functions PTPN13 had, and list some proteins which have the same functions with PTPN13. You can find most of the proteins on our site.

Function Related Protein
phosphatidylinositol 3-kinase regulatory subunit bindingFAM83A;DNM2;PIK3R1;PIK3AP1;FAM83B;XBP1;PTPN13
protein bindingFHL5;PCSK9;USP46;EVI5L;BMP2;MYL12B;TRIP6;RAB37;NAA35
protein tyrosine phosphatase activityMTMR8;MTMR1;EYA1;EYA2;MTMR7A;CDC25A;DUSP2;EYA3;PTPRK

PTPN13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN13 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN13.

RAPGEF6; PKN2; FAS; PLEKHA1; PDCD10

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is the expression of PTPN13 regulated in cells? 04/09/2023

The expression of PTPN13 can be regulated at the transcriptional level by various factors, including transcription factors, epigenetic modifications, and signaling pathways. For example, the tumor suppressor p53 can transcriptionally upregulate PTPN13 expression. Additionally, growth factors, cytokines, and oncogenic signals can modulate PTPN13 expression through their downstream effectors.

Are there any specific inhibitors or activators targeting PTPN13? 04/04/2023

There are no specific inhibitors or activators targeting PTPN13 available. However, further research is underway to identify small molecules or compounds that can modulate PTPN13 activity selectively.

How does PTPN13 interact with its substrates and regulate their activities? 05/20/2021

PTPN13 binds to its substrates through its phosphatase domain and regulates their activities by dephosphorylation. It acts as a negative regulator of signaling pathways by dephosphorylating tyrosine residues on target proteins, thereby modulating their enzymatic activity, protein-protein interactions, and subcellular localization.

Can PTPN13 serve as a prognostic marker or therapeutic target in specific cancer types? 07/23/2020

PTPN13 shows diverse expression patterns in different cancer types, and its potential as a prognostic marker or therapeutic target remains to be fully elucidated. Further studies are needed to determine its clinical significance in specific cancer types and its potential for personalized treatment approaches.

Are there any potential therapeutic strategies targeting PTPN13 for cancer treatment? 07/21/2020

As PTPN13 functions as a tumor suppressor, restoring its activity or expression could be a potential therapeutic strategy. However, direct targeting of PTPN13 is challenging. Alternatively, targeting downstream signaling pathways that are dysregulated in PTPN13-deficient tumors, such as the PI3K/AKT pathway, may provide potential therapeutic opportunities.

What is the role of PTPN13 in cancer development and progression? 04/27/2017

PTPN13 acts as a tumor suppressor in various cancers. Its loss or inactivation is associated with increased cell proliferation, survival, and metastasis. PTPN13 regulates key signaling pathways involved in cancer progression, such as the PI3K/AKT and MAPK pathways, and its dysregulation contributes to tumor growth, invasion, and resistance to therapies.

What are the cellular functions of PTPN13 and its related signaling pathways? 03/18/2017

PTPN13, also known as Fas-associated phosphatase-1 (FAP-1), plays critical roles in various cellular processes, including cell adhesion, migration, proliferation, and survival. It is involved in regulating multiple signaling pathways such as the PI3K/AKT, MAPK, and Wnt pathways.

Customer Reviews (3)

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Reviews
05/13/2020

    The performance of this reagent during the experiment is remarkable, providing the optimal sample preparation conditions.

    12/26/2016

      I am truly grateful for this product as it has successfully resolved protein interference issues that I encountered.

      06/05/2016

        Utilizing this protein reagent, my gel electrophoresis results for experimental samples are clearer, enabling better comparison and analysis.

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