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PTPN2

  • Official Full Name

    protein tyrosine phosphatase, non-receptor type 2

  • Overview

    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
  • Synonyms

    PTPN2; protein tyrosine phosphatase, non-receptor type 2; PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP; tyrosine-protein phosphatase non-receptor type 2; T-cell protein tyrosine phosphatase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTPN2-1519H Active Recombinant Human PTPN2, GST-tagged E.coli GST Full length
Human PTPN2-240H Active Recombinant Human PTPN2(1-341) Protein E. coli 1-341 aa
Human PTPN2-8088H Recombinant Human PTPN2 protein, His & T7-tagged E.coli His/T7 Met1~Gly257 (Accession # P17706)
Human PTPN2-2056H Recombinant Human PTPN2, GST-tagged E.coli GST N-term-346aa
Human PTPN2-470H Recombinant Human PTPN2, Gly & Pro tagged Insect Cell His
Human PTPN2-940H Active Recombinant Human PTPN2 protein, His&GST-tagged Insect Cells His/GST Met1-Asn314
Human PTPN2-464H Recombinant Human PTPN2,GST-tagged,Active E.coli GST
Human PTPN2-567HCL Recombinant Human PTPN2 cell lysate Insect Cell N/A
Human PTPN2-144H Active Recombinant Human PTPN2 Protein, His/GST-tagged Insect cell His/GST 1-314
Human PTPN2-6094H Recombinant Human PTPN2 Protein (Met1-Gly257), N-His tagged E.coli N-His Met1-Gly257
Human PTPN2-3131H Recombinant Human PTPN2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PTPN2-2375H Recombinant Human PTPN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTPN2-85H Recombinant Human PTPN2(Met1-Asn314) Protein, C-6*His-tagged E.coli His
Human PTPN2-2196H Active Recombinant Human PTPN2 protein Insect Cells N/A Met1-Asn314
Mouse Ptpn2-2548M Active Recombinant Mouse Ptpn2, His tagged Insect Cell His Ser 2-Asn 314
Mouse Ptpn2-8089M Recombinant Mouse Ptpn2 protein, His & T7-tagged E.coli His/T7 Met1~Glu237 (Accession # Q06180)
Mouse PTPN2-533MCL Recombinant Mouse PTPN2 cell lysate Insect Cell N/A
Mouse Ptpn2-5238M Recombinant Mouse Ptpn2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PTPN2-4831R Recombinant Rat PTPN2 Protein Mammalian Cell His
Rat PTPN2-4490R Recombinant Rat PTPN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTPN2-4490R-B Recombinant Rat PTPN2 Protein Pre-coupled Magnetic Beads HEK293
Chicken PTPN2-4267C Recombinant Chicken PTPN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTPN2 Related Articles
  • PTPN2 Related Research Area

PTPN2 involved in several pathways and played different roles in them. We selected most pathways PTPN2 participated on our site, such as Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Jak-STAT signaling pathwayIL12BA;IL12RB2;PIK3CA;CCND2;IFNB;IL23;PIK3CD;LIFR;CRFB4

PTPN2 has several biochemical functions, for example, integrin binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN2 itself. We selected most functions PTPN2 had, and list some proteins which have the same functions with PTPN2. You can find most of the proteins on our site.

Function Related Protein
integrin bindingCIB2;VCAM1;IGF1;MMP14;ICAM3;COL4A3;FN1;WISP1A;TGFBI
protein bindingCRYBA1;S100A14;ATG13;TAF6L;NSMCE4A;MTOR;PRPF8;POU2AF1;NOD1
protein kinase bindingCAMK2N1A;ARHGEF7;E2F1;KCNA5;TP53;USF1;Cd24a;CDK5RAP1;RPS6KA3
protein tyrosine phosphatase activityCDC14AA;DUSP16;PTPN20B;PTPN9;DUSP11;PTPRZ1;PTPRC;DUSP2;DUSP23
receptor tyrosine kinase bindingTOB1;PIK3R2;PTPN14;NCK1;FIZ1;ARHGEF16;SOCS5;GNB2L1;LRP4
syntaxin bindingSYT10;NAPAA;CPLX2L;SYT13;STX8;CXorf15;SYT11B;STX16;SYT3

PTPN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN2.

GHR; ITGA1; WASL; CDC42; INSR; SFN; UCHL5; q5ni33_fratt; PSMC1; EGFR

Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).
Li, HJ; Spagnol, G; et al. TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication. JOURNAL OF CELL SCIENCE 127:3269-3279(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the therapeutic effect of specific PTPN2 inhibitors on inflammatory diseases? 09/30/2022

PTPN2 inhibitors can inhibit certain signaling pathways in the inflammatory response, thereby playing a role in the treatment of inflammatory diseases.

Is there a soluble PTPN2 protein? 01/06/2022

Yes, soluble PTPN2 proteins exist that can be detected in extracellular fluids and may play a role in regulating cell-to-cell communication and signal transduction.

What is the modulating effect of soluble PTPN2 protein on immune response? 03/17/2021

PTPN2 protein can interact with receptors on the surface of immune cells to regulate the activation and function of immune cells, thereby playing a role in regulating immune responses.

What is the role of PTPN2 protein in autoimmune diseases? 01/15/2021

Studies have shown that PTPN2 protein plays a certain role in autoimmune diseases, and its expression level may be related to the occurrence and progression of the disease.

Are specific PTPN2 inhibitors useful for the treatment of autoimmune diseases? 11/02/2020

Specific PTPN2 inhibitors can inhibit certain abnormal signaling pathways in autoimmune diseases, thereby playing a role in the treatment of autoimmune diseases.

How does PTPN2 protein regulate immune response? 04/16/2020

This protein can interact with a variety of immune molecules, such as T cell receptors (TCRs) and B cell receptors (BCRs), to regulate immune responses by regulating their phosphorylation status.

Customer Reviews (3)

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Reviews
10/06/2022

    Repeatability is good, and the results of multiple experiments are consistent.

    08/10/2022

      The impurities are very well removed and the purity is very high.

      04/14/2021

        Performance is very stable and the price is very reasonable. I would definitely buy this product again.

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