Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

PTPRK

Official Full Name

protein tyrosine phosphatase, receptor type, K
Overview

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.
Synonyms

PTPRK; protein tyrosine phosphatase, receptor type, K; receptor-type tyrosine-protein phosphatase kappa; R PTP kappa; dJ480J14.2.1; DKFZp686C2268; DKFZp779N1045; OTTHUMP00000017180; OTTHUMP00000017181; OTTHUMP00000017182; OTTHUMP00000017187; OTTHUMP00000040306; Protein tyrosine phosphatase kappa; Protein tyrosine phosphatase kappa precursor; Protein tyrosine phosphatase receptor type K; Protein tyrosine phosphatase receptor type kappa; Protein-tyrosine phosphatase kappa; PTPK; PTPkappa; PTPRK_HUMAN; R-PTP-kappa; Receptor type tyrosine protein phosphatase kappa; OTTHUMP00000233054; OTTHUMP00000233055; OTTHUMP00000233080; protein-tyrosine phosphatase, receptor type, kappa; dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
His|T7
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PTPRK-1432H	Recombinant Human PTPRK protein, His & T7-tagged	E.coli	His/T7	Thr1185~Ser1440 (Accession # Q15262)	Inquiry
Human	PTPRK-3120H	Recombinant Human PTPRK Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	PTPRK-5497H	Recombinant Human PTPRK Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	PTPRK-1805H	Recombinant Human PTPRK Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	PTPRK-1581HFL	Recombinant Full Length Human PTPRK Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	PTPRK-1805H-B	Recombinant Human PTPRK Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	PTPRK-13700M	Recombinant Mouse PTPRK Protein	Mammalian Cell	His		Inquiry
Mouse	PTPRK-7287M	Recombinant Mouse PTPRK Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PTPRK-7287M-B	Recombinant Mouse PTPRK Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Ptprk-5248M	Recombinant Mouse Ptprk Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PTPRK Related Gene Family

PTPRK involved in several pathways and played different roles in them. We selected most pathways PTPRK participated on our site, such as EGFR downregulation, Signal Transduction, Signaling by EGFR, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
EGFR downregulation	AP2B1;STAM2;AP2A2;PTPRK;SPRY1;SPRY2;AP2S1;AP2M1;AP2A1
Signal Transduction	IFT88;PRICKLE1;DISP2;TMED5;LRIG1;RNF31;GPR132B;KIF14;GPR120
Signaling by EGFR	SPRY1;ADAM12;LRIG1;PTPRK;PAG1

PTPRK has several biochemical functions, for example, beta-catenin binding, gamma-catenin binding, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRK itself. We selected most functions PTPRK had, and list some proteins which have the same functions with PTPRK. You can find most of the proteins on our site.

Function	Related Protein
beta-catenin binding	KLF4;TBL1X;TCF7L2;GLI3;LZIC;SLC9A3R1;SOX17;ASH2L;CXADR
gamma-catenin binding	PTBP3;LEF1;APC;TCF7L2;FER;DSG1;PTPRJ;CDH2;PTPRK
hydrolase activity	ACY3.2;ABHD14A;HE1B;EAR2;ACTG2;NDST2;C6AST4;MMP30;USP9
phosphatase activity	C12orf5;PTPN11B;ALPI.2;CDC14A;SSH2B;ALP3;PTPN4A;PTPRJA;EVLA
phosphoprotein phosphatase activity	PPTC7A;PPP1CBL;PPM1DB;PPP1R3B;MTM1;PPP3CC;PPM1BB;PPP2CA;DUSP26
protein kinase binding	WAS;STXBP1;KCNA5;CAMK2N1A;PAK2;TRIM22;LSM2;SV2A;CDK5RAP2
protein tyrosine phosphatase activity	PTENB;PGP;CDC25C;PTPDC1;PTPRJA;PTPRQ;PTPN20B;MTMR4;SSH3

PTPRK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRK here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRK.

Ywhae