PVRL1
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Official Full Name
poliovirus receptor-related 1 (herpesvirus entry mediator C)
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Overview
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009] -
Synonyms
PVRL1; poliovirus receptor-related 1 (herpesvirus entry mediator C); ED4; PRR; HIgR; HVEC; OFC7; PRR1; PVRR; CD111; PVRR1; SK-12; CLPED1; nectin-1; poliovirus receptor-related protein 1; nectin 1; poliovirus receptor-like 1; herpesvirus Ig-like receptor; herpes virus entry mediator C; ectodermal dysplasia 4 (Margarita Island type);
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Rat
- E.coli
- HEK293
- Human Cell
- Fc
- His(C
- ter)
- hFc
- His
- N/A
- N
- T7|His
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PVRL1-3136H | Active Recombinant Human PVRL1, His-tagged | HEK293 | His | Met 1-Thr 334 | |
| Human | PVRL1-106H | Recombinant Human PVRL1 protein, T7/His-tagged | E.coli | T7/His |
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| Human | PVRL1-3217H | Active Recombinant Human PVRL1 protein, His-tagged | HEK293 | His | Gln 31 - Thr 334 | |
| Human | PVRL1-2299HCL | Recombinant Human PVRL1 cell lysate | Human Cell | N/A |
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| Human | PVRL1-2646H | Recombinant Human PVRL1 Protein, His-tagged | E.coli | N-His | Thr153-Arg380 |
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| Human | PVRL1-3045H | Recombinant Human PVRL1 protein, His-tagged | E.coli | His | 31-334 aa | |
| Human | PVRL1-275H | Recombinant Human PVRL1 Protein (ECD), Fc-His-tagged(C-ter) | HEK293 | Fc-His(C-ter) | Met1-Thr334 |
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| Human | PVRL1-276H | Recombinant Human PVRL1 Protein (ECD), His-tagged(C-ter) | HEK293 | His(C-ter) | Met1-Thr334 |
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| Human | PVRL1-1947H | Active Recombinant Human PVRL1 protein, hFc-tagged | HEK293 | hFc | Met1-Thr334 |
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| Human | PVRL1-1948H | Recombinant Human PVRL1 protein, hFc-tagged, Biotinylated | HEK293 | hFc | Met 1-Thr 334 |
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| Human | PVRL1-0568H | Active Recombinant Human PVRL1 protein, Fc-tagged | HEK293 | Fc | Gln31-Thr334 |
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| Rat | Pvrl1-7472R | Recombinant Rat Pvrl1, Fc tagged | Human Cell | Fc |
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| Rat | Pvrl1-7473R | Recombinant Rat Pvrl1 protein, His-tagged | HEK293 | His | Met1-Ala354 |
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| Rat | PVRL1-1409RCL | Recombinant Rat PVRL1 cell lysate | Human Cell | N/A |
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- Involved Pathway
- Protein Function
- Interacting Protein
- PVRL1 Related Research Area
PVRL1 involved in several pathways and played different roles in them. We selected most pathways PVRL1 participated on our site, such as Cell adhesion molecules (CAMs), Adherens junction, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PVRL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | CLDN22;ESAM;CLDN5;MHC2A;ITGAM;ICAM1;SDC1;NCAM1B;CNTN2 |
| Adherens junction | LMO7;WASF1;PTPRF;RHOAA;WASF2;AASS;ACTB;EGFR;TCF7 |
| Herpes simplex infection | IFNB;ALYREF;IL1B;PVRL2;IL12BA;MAVS;OAS1;ARNTL1B;HLA-C |
PVRL1 has several biochemical functions, for example, carbohydrate binding, cell adhesion molecule binding, coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PVRL1 itself. We selected most functions PVRL1 had, and list some proteins which have the same functions with PVRL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | ILLR1;KLRC2;CALR3;KLRF1;CLEC4E;CNTN2;CLEC12A;GANC;MAN2A1 |
| cell adhesion molecule binding | GLYCAM1;NRXN1;POSTN;CADM4;MSN;NLGN1;CADM1;PTPRD;ADAM8 |
| coreceptor activity | RAMP2;RAMP3;ACVR2A;ZP2;CCR5;RGMD;PVRL1;CCR8;TGFBR3 |
| protein binding | HRK;GORASP1;GPC3;TFIP11;EIF1AD;CDK17;FNBP1;TOP1;KLC2 |
| protein heterodimerization activity | HIST1H2BE;H2AFY2;TLR2;TAS1R2;PRMT5;RRAGD;NFE2L2A;HIST1H2AI;CUL3 |
| protein homodimerization activity | GALE;TPD52;PVALB;MCL1B;PPP2R4;APOA2;ZBTB4;DAXX;ZHX2 |
| receptor binding | HSPA1A;EPB49;LYN;GSTK1;WNT2BB;TESPA1;LAMA2;F2;CADM4 |
| virion binding | HSP90B1;TSG101;CLEC4M;PTX3;PPIA;PVRL1;CD209;APCS;HIPK2 |
| virus receptor activity | CCR5;ICAM1;ITGB6;AXL;XPR1;HAVCR1;CLDN1;HYAL2;EFNB2 |
PVRL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PVRL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PVRL1.
PVRL4; PVRL3; vgld_hhv1f_protein; Pick1; MLLT4; gD
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