Pvrl2
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Official Full Name
poliovirus receptor-related 2 (herpesvirus entry mediator B)
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Overview
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] -
Synonyms
PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B); HVEB; PRR2; CD112; PVRR2; poliovirus receptor-related protein 2; nectin-2; poliovirus receptor-like 2; herpesvirus entry protein B;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Antibody
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- Mammalian cells
- Rabbit
- Avi|Fc
- C
- His
- Fc
- GST
- His (Fc)
- Avi
- human|IgG1|Fc
- mFc
- N/A
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- Pvrl2 Related Research Area
Pvrl2 involved in several pathways and played different roles in them. We selected most pathways Pvrl2 participated on our site, such as Cell adhesion molecules (CAMs), Adherens junction, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pvrl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | HLA-G;CLDN10A;JAM3B;HLA-DPA1;NLGN1;NCAM2;MADCAM1;NRXN2;CLDN19 |
| Adherens junction | PTPRM;TCF7;CTNND1;SMAD2;CTNNA2;FYN;PVRL2;BAIAP2A;SMAD3 |
| Herpes simplex infection | TLR2;TAF13;SRPK1B;TRAF6;TLR2-2;MAPK10;IFNA3;IFNGR1;TLR3 |
Pvrl2 has several biochemical functions, for example, cell adhesion molecule binding, coreceptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pvrl2 itself. We selected most functions Pvrl2 had, and list some proteins which have the same functions with Pvrl2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cell adhesion molecule binding | SELL;NLGN1;MSN;CRTAM;DSP;PKP3;CD226;NLGN2;NLGN3 |
| coreceptor activity | ACVR2A;CD28;CCR8;ZP2;CD8A;CD80;RAMP3;ACKR3B;RGMD |
| identical protein binding | MRFAP1L1;ATXN3;CRYAA;DAAM1;CDC42;MSANTD3;RELA;BCL2;Serpina1c |
| protein binding | TGFB3;PTPN13;TAG-260;APLP2;NR2F2;KRT5;FGFBP1;BAZ1B;ILF2 |
| protein homodimerization activity | SYT16;CD200;DPYD;HINT2;CALCOCO2;TCF3B;HPS4;CHRNA7;PLDN |
| receptor binding | PTK6B;TNFSF13;CADM4;PSPN;NPFF;HFE2;DECR2;FIS1;IL29 |
| virus receptor activity | ITGB7;HSPA1A;CD4;NCAM1;HAVCR1;RPSA;DAG1;ITGB5;LDLR |
Pvrl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pvrl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Pvrl2.
MDFI; PVRL3; KRTAP5-9; KRTAP10-5
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