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PYGL

Official Full Name

phosphorylase, glycogen, liver
Overview

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms

PYGL; phosphorylase, glycogen, liver; phosphorylase, glycogen; liver; glycogen phosphorylase, liver form; glycogen storage disease type VI; Hers disease; GSD6;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ
Yeast

Tag

Flag
GST
His
His (Fc)
Avi
MYC
DDK
Myc|DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PYGL-43H	Recombinant Human PYGL, His-tagged	E.coli	His		Inquiry
Human	PYGL-31270TH	Recombinant Human PYGL	Wheat Germ	N/A	847 amino acids	Inquiry
Human	PYGL-7823H	Recombinant Human PYGL protein, His-tagged	E.coli	His	Asn633~Glu820 (Accession # P06737)	Inquiry
Human	PYGL-1819H	Recombinant Human PYGL Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	PYGL-759H	Recombinant Human PYGL Protein (2-846 aa), GST-tagged	E.coli	GST	2-846 aa	Inquiry
Human	PYGL-3176H	Recombinant Human PYGL Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	PYGL-1819H-B	Recombinant Human PYGL Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	PYGL-6128H	Recombinant Human PYGL Protein (Gln370-Val538), N-His tagged	E.coli	N-His	Gln370-Val538	Inquiry
Human	PYGL-1497H	Recombinant Human PYGL Protein (2-846 aa), His-tagged	Yeast	His	2-846 aa	Inquiry
Human	PYGL-416HF	Recombinant Full Length Human PYGL Protein	In Vitro Cell Free System		847 amino acids	Inquiry
Human	PYGL-1275HFL	Recombinant Full Length Human PYGL Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Mouse	Pygl-453M	Recombinant Mouse Pygl Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Mouse	Pygl-2009M	Recombinant Mouse Pygl Protein, His-tagged	E.coli	N-His	Thr603-Phe750	Inquiry
Rat	PYGL-4859R	Recombinant Rat PYGL Protein	Mammalian Cell	His		Inquiry
Rat	Pygl-7824R	Recombinant Rat Pygl protein, His-tagged	E.coli	His	Thr341~Gly509 (Accession# P09811)	Inquiry
Rat	Pygl-7825R	Recombinant Rat Pygl protein, His-tagged	E.coli	His	Thr603~Phe750 (Accession # P09811)	Inquiry
Rat	Pygl-7826R	Recombinant Rat Pygl protein, His-tagged	E.coli	His	Gln73~Val267 (Accession # P09811)	Inquiry
Rat	PYGL-4518R-B	Recombinant Rat PYGL Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PYGL-4518R	Recombinant Rat PYGL Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	PYGL-1871Z	Recombinant Zebrafish PYGL	Mammalian Cell	His		Inquiry
Chicken	PYGL-5962C	Recombinant Chicken PYGL	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PYGL Related Articles

PYGL involved in several pathways and played different roles in them. We selected most pathways PYGL participated on our site, such as Starch and sucrose metabolism, Metabolic pathways, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PYGL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Starch and sucrose metabolism	HK1;PGM2L1;GUSB;AMY2A;UGT1A6A;GPIA;AGLA;AMY1A;AMY2B
Metabolic pathways	ACOT2;AGPS;HSD3B2;ENPP7;PCCA;PNAT10;CRYL1;ST8SIA5;ADK
Insulin signaling pathway	INS1;EIF4E2RS1;INSB;PRKACAA;PKLR;SOCS3B;FOXO1;G6PCA.2;PYGMA
Insulin resistance	RPS6KB1B;PPP1R3CA;PRKAG3;PPP1CAB;OGT.1;CREB3L3;PPP1R3DA;PIK3CA;PTPRFB

PYGL has several biochemical functions, for example, AMP binding, ATP binding, bile acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PYGL itself. We selected most functions PYGL had, and list some proteins which have the same functions with PYGL. You can find most of the proteins on our site.

Function	Related Protein
AMP binding	PRKAG1;PRPS2;PYGM;ACSS2;FBP1;PRKAG2;CYB5R3;PRPS1;ACSS1
ATP binding	MAPK11;BCR;CSF1RA;ATRX;VRK3;PCCB;UCKL1A;HELZ;ITPKB
bile acid binding	FABP1;STARD5;AKR1C2;PLA2G1B;FABP10A;AKR1C21;FABP6;PYGL;NR1H4
drug binding	DHODH;PPARD;ATP5O;HTR2C;CHRM1;FNTB;HTR2A;CYP2C9;ACE
glucose binding	HKDC1;G6PDX;SLC2A8;PYGL;HK2;HK3;UGP2;SLC2A3;GYS1
glycogen phosphorylase activity	PYGMB;PYGB;PYGL;PYGMA;PYGM
protein binding	NBL1;SEC61G;COG8;LARS;SFRP1;MLANA;ATP2B4;PSMB4;NOTCH4
protein homodimerization activity	TWIST1;MGLL;IZUMO3;PARK7;AGXT;CHUK;DMRT2B;NR0B2;S100A5
purine nucleobase binding	PNP;PYGL
pyridoxal phosphate binding	MOCOS;GOT2A;AGXT;MARC2;CCBL1;SRR;HINT2;MARC1;SHMT1
vitamin binding

PYGL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYGL here. Most of them are supplied by our site. Hope this information will be useful for your research of PYGL.

PYGB; USP19; IDH2; BAG1; HSD3B7; IKBKB; GABARAPL2; FKBP5; Ripk3

Liu, J; Wang, X; et al. Maslinic acid modulates glycogen metabolism by enhancing the insulin signaling pathway and inhibiting glycogen phosphorylase. CHINESE JOURNAL OF NATURAL MEDICINES 12:259-265(2014).

Zhou, DX; Zheng, LY; et al. Identification and differential expression of human carcinoma-associated antigens in hepatocellular carcinoma tissues. EXPERIMENTAL BIOLOGY AND MEDICINE 238:167-175(2013).