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Pyruvate kinase

Official Full Name

Pyruvate Kinase
Overview

Pyruvate kinase is also known as ATP:pyruvate phosphotransferase. There are5isoforms of piruvate kinase in mammals: L, R, M1 and M2. L type is the major isoform in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues as well as in most cancer cells. Defects in PKLR (pyruvate kinase L and R) are the cause of pyruvate kinase hyperactivity; also known as high red cell ATP syndrome. This autosomal dominant phenotype is characterized by increase of red blood cell ATP. Also defects in PKLR are a cause of chronic nonspherocytic hemolytic anemia (CNSHA); also called hereditary nonspherocytic hemolytic anemia.
Synonyms

CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; OPA interacting protein 3; Opa interactivity protein; PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PKM2; PYKM; Pyruvate kinase 1; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozyme R/L; Pyruvate kinase isozymes M1/M2; Pyruvate kinase liver and blood cell; Pyruvate kinase liver and RBC; Pyruvate kinase liver and RBC type; Pyruvate kinase M2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; Pyruvate kinase type L; R type/L type pyruvate kinase; Red cell/liver pyruvate kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; Pyruvate Kinase;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Microorganism	PKLR-1544	Pyruvate kinase	Microorganism	N/A		Inquiry
	Kit-2456	Pyruvate Kinase Assay Kit		N/A		Inquiry

Pyruvate kinase Related Articles

Pyruvate kinase involved in several pathways and played different roles in them. We selected most pathways Pyruvate kinase participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Pyruvate kinase were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

Pyruvate kinase has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Pyruvate kinase itself. We selected most functions Pyruvate kinase had, and list some proteins which have the same functions with Pyruvate kinase. You can find most of the proteins on our site.

Function	Related Protein

Pyruvate kinase has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pyruvate kinase here. Most of them are supplied by our site. Hope this information will be useful for your research of Pyruvate kinase.

Antoniu, S; et al. Fresh from the designation pipeline: orphan drugs recently designated in the European Union (August-October 2014). EXPERT OPINION ON ORPHAN DRUGS 3:321-328(2015).

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).