QARS
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Official Full Name
glutaminyl-tRNA synthetase
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Overview
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. -
Synonyms
QARS; glutaminyl-tRNA synthetase; glutamine--tRNA ligase; glutamine tRNA ligase; glutamine-tRNA synthetase; GLNRS; PRO2195;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293T
- Mammalian Cell
- His
- His|T7
- Myc
- DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | QARS-8213H | Recombinant Human QARS protein, His & T7-tagged | E.coli | His/T7 | Pro514~Val775 (Accession # P47897) |
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| Human | QARS-28669TH | Recombinant Human QARS, His-tagged | E.coli | His |
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| Human | QARS-2132HCL | Recombinant Human QARS cell lysate | N/A |
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| Human | QARS-6576H | Recombinant Human QARS Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Mouse | Qars-5277M | Recombinant Mouse Qars Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | Qars-8214R | Recombinant Rat Qars protein, His & T7-tagged | E.coli | His/T7 | Ala2~Asp206 (Accession # Q66H61) |
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| Zebrafish | QARS-11425Z | Recombinant Zebrafish QARS | Mammalian Cell | His |
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| Chicken | QARS-2011C | Recombinant Chicken QARS | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
QARS involved in several pathways and played different roles in them. We selected most pathways QARS participated on our site, such as Aminoacyl-tRNA biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with QARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | GARS;MARS;AARS;KARS;EARS2;DARS;GATB;WARS;NARS |
| Metabolic pathways | NT5C1B-RDH14;GLDC;GUK1B;AOX3L1;HYAL1;PLD1A;GNS;RABGNT1;CYP2J5 |
QARS has several biochemical functions, for example, ATP binding, glutamine-tRNA ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by QARS itself. We selected most functions QARS had, and list some proteins which have the same functions with QARS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SMYHC2;MARS;UBE2A;SPS2;NAIP1;ATP5B;FGFR4;NRBP1;NEK4 |
| glutamine-tRNA ligase activity | |
| protein binding | LRP6;TIMELESS;FAM60A;RNF216;HAUS1;COX4I2;MED27;SCAF8;ZNF550 |
QARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with QARS here. Most of them are supplied by our site. Hope this information will be useful for your research of QARS.
AES; TRIP13; KLC3; TCF12; LZTS2; TRAF4; RNF11
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