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RABGEF1

Official Full Name

RAB guanine nucleotide exchange factor (GEF) 1
Overview

RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]
Synonyms

RABGEF1; RAB guanine nucleotide exchange factor (GEF) 1; RAP1; RABEX5; rabex-5; rab5 GDP/GTP exchange factor; rabaptin-5-associated exchange factor for Rab5;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
His|SUMO
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RABGEF1-2142H	Recombinant Human RABGEF1, His-tagged	E.coli	His	C-term-358aa	$319 / 25ug
Human	RABGEF1-2575HCL	Recombinant Human RABGEF1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RABGEF1-1149H	Recombinant Human RABGEF1 Protein (1-491 aa), His-SUMO-tagged	E.coli	His/SUMO	1-491 aa	Inquiry
Mouse	RABGEF1-13849M	Recombinant Mouse RABGEF1 Protein	Mammalian Cell	His		Inquiry
Mouse	RABGEF1-7372M	Recombinant Mouse RABGEF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Rabgef1-5339M	Recombinant Mouse Rabgef1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	RABGEF1-7372M-B	Recombinant Mouse RABGEF1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	RABGEF1-11096Z	Recombinant Zebrafish RABGEF1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

RABGEF1 involved in several pathways and played different roles in them. We selected most pathways RABGEF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RABGEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

RABGEF1 has several biochemical functions, for example, DNA binding, Rab GTPase binding, Rab guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RABGEF1 itself. We selected most functions RABGEF1 had, and list some proteins which have the same functions with RABGEF1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	POLR3F;HIST1H2AL;DERL3;PROX2;FOXC1A;JUNBA;KDM1B;HELZ2;TERF1
Rab GTPase binding	RAB11FIP1;RABGAP1L;NDRG1;EXPH5;TMEM127;GAS8;RAB11FIP2;SYTL1;CFAP45
Rab guanyl-nucleotide exchange factor activity	DENND2A;RIN3;RAB3IP;RABGEF1;SBF1;FAM116A;DENND3;TRAPPC4;DENND2D
protein binding	EFHC1;SSSCA1;NUDT4;CORO1B;EPS8;OLR1;ATP6V1C2;MGAT5B;ZAK
ubiquitin protein ligase activity	MED24;RNF146;UBE3A;RNF14;ARIH1;UHRF1;PPIL2;ANKIB1A;UBE2KB
zinc ion binding	LTA4H;ZNF598;RPH3A;SHRPRBCK1R;FHL1B;ZDHHC14;PRKCA;NR3C2;TRIM44

RABGEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RABGEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RABGEF1.

UBB; EGFR; YWHAB; YWHAG; TEAD4; UBC