rad17
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  • Official Full Name
  • RAD17 homolog
  • Background
  • The human checkpoint protein Rad17 and its fission and budding yeast orthologues (Schizosaccharomyces pombe Rad17 and Saccharomyces cerevisiae Rad24, respectively) are involved in the activation of checkpoint signals in response to DNA damage or disruptio
  • Synonyms
  • RAD17; RAD17 homolog (S. pombe); RAD1 (S. pombe) homolog; cell cycle checkpoint protein RAD17; CCYC; RAD17Sp; Rad24; RAD1 homolog; Rad17-like protein; RF-C activator 1 homolog; RF-C/activator 1 homolog; cell cycle checkpoint protein (RAD17); R24L
Cat.#:RAD17-2153HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD17 Protein, His-tagged
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Cat.#:RAD17-2152HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD17, GST-tagged
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Cat.#:RAD17-7137CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAD17
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Cat.#:RAD17-771ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RAD17
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Cat.#:RAD17-2562HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAD17 293 Cell Lysate
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Cat.#:RAD17-2563HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAD17 293 Cell Lysate
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Involved Pathway

RAD17 involved in several pathways and played different roles in them. We selected most pathways RAD17 participated on our site, such as Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD17 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of ATR in response to replication stress
DBF4; RAD9A; MCM8; MCM10; CDK2; CLSPN; RAD17; HUS1; RAD1; RAD9B
Cell Cycle
NUF2; ORC3; CCNB2; PCM1; LEMD3; BARD1; MND1; SMC2; RCC2; RAD9A
Cell Cycle Checkpoints
RAD17; RNF168; CHEK2; MCM8; UIMC1; CDK2; CHEK1; YWHAQ; HUS1; THRSP
DNA Double-Strand Break Repair
KDM4A; HUS1; DNA2; RAD1; BABAM1; CHEK1; BRCC3; UIMC1; RAD17; KDM4B
DNA Repair
CLSPN; ACTR5; ZFP830; WRN; BABAM1; ALKBH2; PARP2; UBE2V2; COPS7B; MAD2L2
DNA damage response
GADD45G; GADD45A; CHEK2; RAD9A; TLK2; DDB2; RAD1; CDK5; HUS1B; RAD17
G2/M Checkpoints
THRSP; FAM175A; BABAM1; RAD9; UIMC1; RAD9B; RNF168; BRCC3; RAD1; TP53BP1
Gastric cancer network 2
S100A6; PLAC8; RAD17; CHTF18; ATAD2; SNRPN; TOP2A; MTDH; DSCC1; SNURF

Protein Function

RAD17 has several biochemical functions, for example, ATP binding, DNA clamp loader activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD17 itself. We selected most functions RAD17 had, and list some proteins which have the same functions with RAD17. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SYK; IFIH1; ABCG1; KATNAL1; RTCB; PAK6; ADK; ABCB7; ACTA1B; MCM9
Function DNA clamp loader activity
Related Protein RAD17; RFC3
Function protein binding
Related Protein RASSF7; ANO6; SRSF5; KRTAP8-1; UXT; PGM1; LYAR; MNAT1; TMEM93; TAX1BP3

Interacting Protein

RAD17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD17 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD17.
NBN; MRE11A; RAD50; RAD9A; FZR1; USP20; PRMT6; npm_alk; CBX6; CBX7

RAD17 Related Articles

Sukhanova, MV; D'Herin, C; et al. Interaction of Ddc1 and RPA with single-stranded/double-stranded DNA junctions in yeast whole cell extracts: Proteolytic degradation of the large subunit of replication protein A in ddc1 Delta strains. DNA REPAIR 22:30-40(2014).
Young, JL; Koon, EC; et al. Differential hRad17 expression by histologic subtype of ovarian cancer. JOURNAL OF OVARIAN RESEARCH 4:-(2011).