RALGDS
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Official Full Name
ral guanine nucleotide dissociation stimulator
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Overview
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010] -
Synonyms
RALGDS; ral guanine nucleotide dissociation stimulator; RGF; RGDS; RalGEF; ral guanine nucleotide exchange factor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
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- Mammalian cells
- C
- Myc
- DDK
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- GST
- His
- His (Fc)
- Avi
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- RALGDS Related Articles
RALGDS involved in several pathways and played different roles in them. We selected most pathways RALGDS participated on our site, such as Ras signaling pathway, Rap signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RALGDS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ras signaling pathway | GNB1;KSR2;KRAS;GNG10;MAPK3;GRIN2B;SOS1;MAPK9;RASSF1 |
Rap signaling pathway | FGF9;MAPK12;MAGI2;RAC3;PIK3CB;MAPK1;FGF3;FGF1;TLN1 |
Phospholipase D signaling pathway | PIK3R5;SPHK1;Adcy4;CYTH2;DGKD;PLA2G4C;INS;PIK3CD;PLA2G4F |
Pathways in cancer | FOS;WNT5A;APC;CSF3R;FZD2;RXRB;MAPK8;WNT9A;LAMA2 |
Colorectal cancer | PIK3CD;CCND1;PIK3CG;MSH2;MAPK3;MLH1;AKT1;FOS;PIK3CA |
Pancreatic cancer | IKBKG;SMAD4;TRP53;BCL2L1;MAPK9;AKT2;KRAS;MAPK1;BRAF |
Choline metabolism in cancer | PLA2G4F;WASL;MAPK9;Pdgfa&Pdgfb;PRKCG;MTOR;TAE1;PIP5K1C;PIP5K1A |
RALGDS has several biochemical functions, for example, GTPase regulator activity, guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RALGDS itself. We selected most functions RALGDS had, and list some proteins which have the same functions with RALGDS. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase regulator activity | GPSM2;TSC1A;WAS;GPSM1B;RIMS1;RALGDS;GPSM2L;RUNDC3A;WASL |
guanyl-nucleotide exchange factor activity | ARHGEF7;SERGEF;GDPGP1;TBXA2R;TBXAS1;RASGRF2B;RINL;ARFGEF2;RASGEF1BA |
protein binding | ARMC1;ZFPM2;WNT11;RAB27B;C14orf159;ARL2BP;C5orf20;CNOT8;THOC4 |
RALGDS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RALGDS here. Most of them are supplied by our site. Hope this information will be useful for your research of RALGDS.
HRAS; RAP1B; MAPK3; KRAS; CD68; RRAS2; Rit2; RIT1
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