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RALGDS

  • Official Full Name

    ral guanine nucleotide dissociation stimulator

  • Overview

    Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
  • Synonyms

    RALGDS; ral guanine nucleotide dissociation stimulator; RGF; RGDS; RalGEF; ral guanine nucleotide exchange factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RALGDS-30899TH Recombinant Human RALGDS, GST-tagged E.coli GST
Human RALGDS-1124H Recombinant Human RALGDS protein, GST-tagged E.coli GST
Human RALGDS-2168H Recombinant Human RALGDS, GST-tagged E.coli GST 553-902aa
Human RALGDS-2169H Recombinant Human RALGDS, MYC/DDK-tagged HEK293 Myc/DDK
Human RALGDS-2541HCL Recombinant Human RALGDS 293 Cell Lysate HEK293 N/A
Human RALGDS-3839HFL Recombinant Full Length Human RALGDS, Flag-tagged Mamanlian cells Flag
Human RALGDS-1855H Recombinant Human RALGDS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RALGDS-439H Recombinant Human RALGDS Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human RALGDS-1001HFL Recombinant Full Length Human RALGDS Protein, C-Flag-tagged Mammalian cells Flag
Human RALGDS-1855H-B Recombinant Human RALGDS Protein Pre-coupled Magnetic Beads HEK293
Mouse Ralgds-5360M Recombinant Mouse Ralgds Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat RALGDS-4918R Recombinant Rat RALGDS Protein Mammalian Cell His
Rat RALGDS-4577R-B Recombinant Rat RALGDS Protein Pre-coupled Magnetic Beads HEK293
Rat RALGDS-4577R Recombinant Rat RALGDS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RALGDS Related Articles

RALGDS involved in several pathways and played different roles in them. We selected most pathways RALGDS participated on our site, such as Ras signaling pathway, Rap signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RALGDS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayGNB1;KSR2;KRAS;GNG10;MAPK3;GRIN2B;SOS1;MAPK9;RASSF1
Rap signaling pathwayFGF9;MAPK12;MAGI2;RAC3;PIK3CB;MAPK1;FGF3;FGF1;TLN1
Phospholipase D signaling pathwayPIK3R5;SPHK1;Adcy4;CYTH2;DGKD;PLA2G4C;INS;PIK3CD;PLA2G4F
Pathways in cancerFOS;WNT5A;APC;CSF3R;FZD2;RXRB;MAPK8;WNT9A;LAMA2
Colorectal cancerPIK3CD;CCND1;PIK3CG;MSH2;MAPK3;MLH1;AKT1;FOS;PIK3CA
Pancreatic cancerIKBKG;SMAD4;TRP53;BCL2L1;MAPK9;AKT2;KRAS;MAPK1;BRAF
Choline metabolism in cancerPLA2G4F;WASL;MAPK9;Pdgfa&Pdgfb;PRKCG;MTOR;TAE1;PIP5K1C;PIP5K1A

RALGDS has several biochemical functions, for example, GTPase regulator activity, guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RALGDS itself. We selected most functions RALGDS had, and list some proteins which have the same functions with RALGDS. You can find most of the proteins on our site.

Function Related Protein
GTPase regulator activityGPSM2;TSC1A;WAS;GPSM1B;RIMS1;RALGDS;GPSM2L;RUNDC3A;WASL
guanyl-nucleotide exchange factor activityARHGEF7;SERGEF;GDPGP1;TBXA2R;TBXAS1;RASGRF2B;RINL;ARFGEF2;RASGEF1BA
protein bindingARMC1;ZFPM2;WNT11;RAB27B;C14orf159;ARL2BP;C5orf20;CNOT8;THOC4

RALGDS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RALGDS here. Most of them are supplied by our site. Hope this information will be useful for your research of RALGDS.

HRAS; RAP1B; MAPK3; KRAS; CD68; RRAS2; Rit2; RIT1

Mach, N; Gao, Y; et al. The peripheral blood transcriptome reflects variations in immunity traits in swine: towards the identification of biomarkers. BMC GENOMICS 14:-(2013).
Samakoglu, S; Deevi, DS; et al. Preclinical Rationale for Combining an EGFR Antibody with Cisplatin/Gemcitabine for the Treatment of NSCLC. CANCER GENOMICS & PROTEOMICS 9:77-92(2012).
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