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RAPGEF1

  • Official Full Name

    Rap guanine nucleotide exchange factor (GEF) 1

  • Overview

    This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
  • Synonyms

    RAPGEF1; Rap guanine nucleotide exchange factor (GEF) 1; GRF2, guanine nucleotide releasing factor 2 (specific for crk proto oncogene); rap guanine nucleotide exchange factor 1; C3G; CRK SH3-binding GNRP; guanine nucleotide-releasing factor 2 (specific f;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RAPGEF1-2180H Recombinant Human RAPGEF1, His-tagged E.coli His 748-1095aa
Human RAPGEF1-2522HCL Recombinant Human RAPGEF1 293 Cell Lysate HEK293 N/A
Human RAPGEF1-5829H Recombinant Human RAPGEF1 Protein (Lys780-Asn1035), N-His tagged E.coli N-His Lys780-Asn1035
  • Involved Pathway
  • Protein Function
  • Interacting Protein

RAPGEF1 involved in several pathways and played different roles in them. We selected most pathways RAPGEF1 participated on our site, such as Rap signaling pathway, Focal adhesion, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayCDC42;RAP1GAP;VEGFB;ACTB;FGF4;ITGA2B;ITGB1;FGF12;PFN2
Focal adhesionCOL2A1;MYLPF;PARVB;COL4A6;COL2A1A;RAC2;THBS3;MAPK6;PIK3R3A
Neurotrophin signaling pathwayPDPK1;KIDINS220;NTRK3;MAPK13;NFKBIA;NRAS;ATF4;PIK3R2;IRAK4
Insulin signaling pathwayMAP2K1;BAD;PRKACB;PDPK1B;HK1;CBL;CBLB;PIK3R1;PCK2
Renal cell carcinomaFLCN;TCEB1;EGLN1;ARAF;PIK3R3;PIK3CA;MET;PAK3;ETS1

RAPGEF1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF1 itself. We selected most functions RAPGEF1 had, and list some proteins which have the same functions with RAPGEF1. You can find most of the proteins on our site.

Function Related Protein

RAPGEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF1.

CRK; ABL1; GRB2; CRKL; FYN; SRC; NCK1

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