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RAPGEF3

  • Official Full Name

    Rap guanine nucleotide exchange factor (GEF) 3

  • Overview

    EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signal
  • Synonyms

    RAPGEF3; Rap guanine nucleotide exchange factor (GEF) 3; rap guanine nucleotide exchange factor 3; bcm910; cAMP GEFI; EPAC; exchange protein directly activated by cAMP 1; EPAC 1; 9330170P05Rik; exchange fact;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RAPGEF3-1022H Recombinant Human RAPGEF3, GST-tagged Wheat Germ GST
Human RAPGEF3-2181H Recombinant Human RAPGEF3, GST-tagged E.coli GST 398-746aa
Human RAPGEF3-135H Recombinant Human RAPGEF3, MYC/DDK-tagged HEK293 Myc/DDK
Human RAPGEF3-1032H Recombinant Human Rap guanine nucleotide exchange factor (GEF) 3 E.coli N/A
Human RAPGEF3-2521HCL Recombinant Human RAPGEF3 293 Cell Lysate HEK293 N/A
Human RAPGEF3-3595H Recombinant Human RAPGEF3 protein, His-tagged E.coli His 441-788 aa
Human RAPGEF3-3474H Recombinant Human RAPGEF3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RAPGEF3-5103HFL Recombinant Full Length Human RAPGEF3, Flag-tagged Mamanlian cells Flag
Human RAPGEF3-3056H Recombinant Human RAPGEF3 protein, His-tagged E.coli His 43-203 aa
Mouse Rapgef3-5377M Recombinant Mouse Rapgef3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat RAPGEF3-4927R Recombinant Rat RAPGEF3 Protein Mammalian Cell His
Rat RAPGEF3-4586R Recombinant Rat RAPGEF3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RAPGEF3-4586R-B Recombinant Rat RAPGEF3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RAPGEF3 Related Articles

RAPGEF3 involved in several pathways and played different roles in them. We selected most pathways RAPGEF3 participated on our site, such as Adaptive Immune System, Adrenergic signaling in cardiomyocytes, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemFGF8B;WWP1;CRTAM;FBXO27;ASB7;LAIR2;SPSB4;CYBA;CDKN1B
Adrenergic signaling in cardiomyocytesCACNG7A;AGTR1B;SCN1BB;BCL2A;PPP2R2CA;ADRB3A;MAPK13;PPP2R2C;PLCB2
HemostasisPRTN3;KCNMA1;CENPE;G6b;RACGAP1;F13A1A.1;ZFPM2A;PHF21A;DOCK8
Immune SystemTRIM17;SIGLEC6;NLRP4B;BTR09;ASB7;HCST;BTLA;SIGLEC8;TNFSF13B
Integrated Pancreatic Cancer PathwayTOP1;TFF1;FST;RAPGEF3;MAPK4;IL11;CASP12;CD82;PPP1R13L
Integration of energy metabolismMARCKSA;RAPGEF3;KCNC2;SYT5;ARL2BP;KCNS3;KCNS3A;MARCKSB;KCNJ11
Integrin alphaIIb beta3 signalingITGB3A;LOC100514666;FN1B;RAPGEF3;RAPGEF4

RAPGEF3 has several biochemical functions, for example, Rap guanyl-nucleotide exchange factor activity, cAMP binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF3 itself. We selected most functions RAPGEF3 had, and list some proteins which have the same functions with RAPGEF3. You can find most of the proteins on our site.

Function Related Protein
Rap guanyl-nucleotide exchange factor activityRAP1A;RAPGEF3;RAPGEF5
cAMP bindingPDE10A;RAPGEF4;PDE4B;HCN2;PDE4D;PRKAR2B;PDE11A;PDE2A;RAPGEF3
guanyl-nucleotide exchange factor activityDIS3;RASGEF1BA;RIC8A;BCAR3;KALRN;RASGRP2;DENND1C;FGD6;ARHGEF1B
protein bindingAXL;NEK2;SLC22A5;CD5;LTA4H;ARHGEF15;MMP15;FEM1B;HNRNPUL1
protein domain specific bindingRCC2;HSPA5;YWHAE2;IGBP1;ARFIP2B;MYH9;DDX6;TFDP2;HMGB2

RAPGEF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF3.

PDE3B; 3',5'-cyclic amp; 7-ch-c_amp; mant-gdp; RAP1B; PIK3R6

Vadnais, ML; Aghajanian, HK; et al. Signaling in Sperm: Toward a Molecular Understanding of the Acquisition of Sperm Motility in the Mouse Epididymis. BIOLOGY OF REPRODUCTION 89:-(2013).
Fang, ZQ; Zang, WD; et al. Gene expression profile and enrichment pathways in different stages of bladder cancer. GENETICS AND MOLECULAR RESEARCH 12:1479-1489(2013).
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