rara
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  • Official Full Name
  • retinoic acid receptor, alpha
  • Background
  • This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
  • Synonyms
  • RARA; retinoic acid receptor, alpha; retinoic acid receptor alpha; NR1B1; RAR; RAR-alpha; retinoic acid receptor, alpha polypeptide; nuclear receptor subfamily 1 group B member 1; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear recep
Cat.#:RARA-1130HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RARA, Ligand Binding Domain
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Cat.#:RARA-1131HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RARA, Ligand Binding Domain, GST-tagged
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Cat.#:RARA-190HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Retinoic Acid Receptor, Alpha, His-tagged
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Cat.#:RARA-111HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Retinoic acid receptor alpha, GST-tagged
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Cat.#:RARA-170HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RARA protein, GST/His-tagged
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Cat.#:RARA-2510HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RARA, His-tagged
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Cat.#:RARA-31053THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RARA, His-tagged
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Cat.#:RARA-31319THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RARA, His-tagged
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Cat.#:RARA-31320THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RARA, His-tagged
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Cat.#:RARA-13932MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RARA Protein
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Cat.#:Rara-5686MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rara protein, His & T7-tagged
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Cat.#:Rara-5687RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Rara protein, His & T7-tagged
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Cat.#:RARA-6105CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RARA
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Cat.#:RARA-2515HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RARA 293 Cell Lysate
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Cat.#:RARA-2516HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RARA 293 Cell Lysate
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Involved Pathway

RARA involved in several pathways and played different roles in them. We selected most pathways RARA participated on our site, such as Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with RARA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pathways in cancer
PTGER3; RAF1; MAP2K2; FGF21; ARNT; FGF9; FGF3; TP53; GNAI3; XIAP
Transcriptional misregulation in cancer
BCL6; NR4A3; RUNX1T1; PTCRA; FOXO1; MET; H3F3C; Bcl2a1b; LDB1; PAX5
Acute myeloid leukemia
ARAF; GRB2; CHUK; PIK3CA; CCND1; AKT3; MAPK3; TCF7L2; IKBKG; ZBTB16

Protein Function

RARA has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, alpha-actinin binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RARA itself. We selected most functions RARA had, and list some proteins which have the same functions with RARA. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein TBX5; TFAP2C; KAT2B; BCL6AB; NFKB1; ETV3; FOXK1; ZNF812; MEF2D; ARID3A
Function alpha-actinin binding
Related Protein MAGI1; PPARG; ADORA2A; XIRP2; PKD2L1; LRRC10; RARA; KCNN2; KCNA5; ALMS1
Function chromatin DNA binding
Related Protein GATA1; MYOD1; NEUROG3; THRA; SLAMF7; RUVBL2; RXRA; GRHL3; APEX1; INSM1B
Function enzyme binding
Related Protein PPP3CA; NR5A1; XRCC1; JUND; DDC; YWHAE; BTG1; UGT1A2; IL6R; SCN5A
Function protein binding
Related Protein JDP2; C19orf57; ADAP2; CDK18; ATP6V0C; BRK1; PHF1; EVL; HELT; ISL1
Function protein domain specific binding
Related Protein RHOA; IL1B; MTOR; IGBP1; YWHAG1; KPNB1; TWIST1; Akap2; LAMP1; MECP2
Function protein heterodimerization activity
Related Protein CHRAC1; H2AFV; IRAK2; HMG20B; USF2; SOX6; PBX1; SUPT3H; HIST1H4E; ZHX1
Function protein kinase A binding
Related Protein AKAP5; AKAP7; DACT1; AKAP6; MYRIP; NBEA; AKAP4; AKAP14; Akap3; DACT2
Function protein kinase B binding
Related Protein BCL10; TRAF6; APPL1; CDC37; CCDC88A; PINK1; RARA; ANKRD2; PDE3B; BAD
Function receptor binding
Related Protein PLG; FGG; F2; PAOX; SEMA4D; WNT7AA; NRG3; Fgf15; HLA-F; FGF12A
Function retinoic acid binding
Related Protein LCN12; RARA; UGT1A1; LRAT; CRABP1B; CRABP2; NR2F2; CRABP1; UGT1A7; SERPINA5
Function retinoic acid receptor activity
Related Protein RARGB; RARA; RARG; NR1D4B; RARAA; RXRA; RARB; RARGA; ESRRG; RARAB
Function retinoic acid-responsive element binding
Related Protein RXRA; RARA; ZFP536
Function steroid hormone receptor activity
Related Protein ESR2; NR1H4; NR2E3; RXRB; VDRA; GPR30; PGR; PPARA; NR2F1; VDRB
Function transcription coactivator activity
Related Protein MED13; FHL5; RNF14; ATF6; UTF1; NPM1; TFDP1; GMEB1; NACA; MAGED1
Function transcription corepressor activity
Related Protein ZBTB32; TGIF1; RCOR2; KCTD1; LIMD1; TOB1; TAF9B; ANKRD1; CBFA2T3; EID1
Function transcription factor activity, sequence-specific DNA binding
Related Protein HIVEP2; GATA1; LMX1B; ZNF649; UBP1; ZFP36L1; ZNF501; ZKSCAN6; ASCL1B; GATA5
Function transcription factor binding
Related Protein THRA; BRD7; CRY1; RPS3; PSMD10; YWHAZ; FOXO1; PBX1; RBL1; GCM1
Function zinc ion binding
Related Protein BIRC8; CA3; MLL1; RYBP; CPE; PML; LHX8A; CALB1; TXNDC17; MATR3L

Interacting Protein

RARA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RARA here. Most of them are supplied by our site. Hope this information will be useful for your research of RARA.
RXRG; RXRA; MED1

RARA Related Articles

Yin, CC; Jain, N; et al. Identification of a Novel Fusion Gene, IRF2BP2-RARA, in Acute Promyelocytic Leukemia. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK 13:19-22(2015).
Mueller, GA; Maleki, SJ; et al. Identification of Maillard reaction products on peanut allergens that influence binding to the receptor for advanced glycation end products. ALLERGY 68:1546-1554(2013).