rara
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  • Official Full Name
  • retinoic acid receptor, alpha
  • Background
  • This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
  • Synonyms
  • RARA; retinoic acid receptor, alpha; retinoic acid receptor alpha; NR1B1; RAR; RAR-alpha; retinoic acid receptor, alpha polypeptide; nuclear receptor subfamily 1 group B member 1; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear recep
Cat.#:RARA-1130HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RARA, Ligand Binding Domain
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Cat.#:RARA-1131HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RARA, Ligand Binding Domain, GST-tagged
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Cat.#:RARA-190HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Retinoic Acid Receptor, Alpha, His-tagged
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Cat.#:RARA-111HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Retinoic acid receptor alpha, GST-tagged
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Cat.#:RARA-170HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RARA protein, GST/His-tagged
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Cat.#:RARA-2510HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RARA, His-tagged
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Cat.#:RARA-31053THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RARA, His-tagged
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Cat.#:RARA-31319THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RARA, His-tagged
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Cat.#:RARA-31320THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RARA, His-tagged
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Cat.#:RARA-13932MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RARA Protein
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Cat.#:Rara-5686MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rara protein, His & T7-tagged
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Cat.#:Rara-5687RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Rara protein, His & T7-tagged
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Cat.#:RARA-6105CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RARA
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Cat.#:RARA-2515HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RARA 293 Cell Lysate
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Cat.#:RARA-2516HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RARA 293 Cell Lysate
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Involved Pathway

RARA involved in several pathways and played different roles in them. We selected most pathways RARA participated on our site, such as Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with RARA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pathways in cancer
STAT1; GNAS; BMP4; IKBKB; PML; SPI1; PRKCG; CCDC6; RASSF1; HSP90AA1
Transcriptional misregulation in cancer
CD40; HIST1H3E; ATM; ETV6; SSX1; RXRA; WNT16; FOXO1; CD86; RUNX2
Acute myeloid leukemia
LEF1; MAPK3; MAPK1; MTOR; GRB2; RPS6KB2; PIK3R1; FLT3; ARAF; RELA

Protein Function

RARA has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, alpha-actinin binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RARA itself. We selected most functions RARA had, and list some proteins which have the same functions with RARA. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein GATA2B; ATF5; ZFP551; DMRT1; POGZA; ACTN4; POU3F4; BARHL2; ZFP583; RFX6
Function alpha-actinin binding
Related Protein DAG1; ALMS1; RARA; PPARG; XIRP2; KCNA5; LRRC10; MAGI1; PKD2L1; MYOT
Function chromatin DNA binding
Related Protein MED1; RARA; H2AFY2; HIST1H1C; HIST1H1B; EP300; MYOD1; PPARGC1A; NKAP; BCL6
Function enzyme binding
Related Protein RAC1; SIRT3; LGALS9; NCOA1; TH; HMOX1; UGT1A6; SNX12; ZNHIT6; ECM1
Function protein binding
Related Protein SKP1; ATG5; PLXNC1; DOHH; SMURF1; OSBPL2; C11orf46; TEF; KANSL2; AOC3
Function protein domain specific binding
Related Protein CASP2; ITGA3; RQCD1; ARFIP2A; EFS; ST13; SHC4; CA; YWHABL; BASP1
Function protein heterodimerization activity
Related Protein CLCF1; HIST1H2BP; MID2; TAP1; CHRNA5; CHRNA3; HIST1H2AC; BTBD11A; IRAK3; UGT1A6
Function protein kinase A binding
Related Protein DACT2; AKAP7; AKAP14; LRRK2; Akap3; RARA; AKAP13; DACT1; AKAP5; Akap2
Function protein kinase B binding
Related Protein RARA; TRAF6; BAD; CDC37; CCDC88A; PINK1; ANKRD2; PDE3B; BCL10; APPL1
Function receptor binding
Related Protein CSK; NRG3; CSNK2B; PTK2AA; LIF; ARPP19A; FGF8A; ABCA1; SNX17; ANGPTL1
Function retinoic acid binding
Related Protein UGT1A2; CYP26B1; LRAT; UGT1A9; NR2F2; SERPINA5; UGT1A7; RARA; CRABP1A; CRABP2A
Function retinoic acid receptor activity
Related Protein RARA; RARGB; RXRA; RARAB; RARGA; RARG; RARAA; ESRRG; NR1D4B; RARB
Function retinoic acid-responsive element binding
Related Protein RXRA; ZFP536; RARA
Function steroid hormone receptor activity
Related Protein RARGA; RXRB; NR1D2; NR1H3; HNF4G; ESR2B; NR5A1B; ESRRB; RORAA; NR1D2B
Function transcription coactivator activity
Related Protein RFXAP; TFDP1B; TFDP1; NACA; TUBB3; BRCA1; ZSCAN1; RNF20; ESR2; KDM5A
Function transcription corepressor activity
Related Protein MSC; JUNB; APEX1; CTBP2; KLF12; ZFPM1; AES; HDAC5; CIR1; YAF2
Function transcription factor activity, sequence-specific DNA binding
Related Protein OTX1B; SMAD3; PA2G4B; ZNF202; HOXD3A; EHF; ZEB1; E2F1; NFE2L1B; NTNG1
Function transcription factor binding
Related Protein POU1F1; PARK7; GTF2B; MYC; NFKB1; PPP1R13BA; HEYL; ADD1; SUFU; AHR
Function zinc ion binding
Related Protein ADAMTS16; TRIM62; TRIM64C; CA4B; RBM4.1; NR1D2B; ANPEPA; FBXO11; TET2; NR2F2

Interacting Protein

RARA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RARA here. Most of them are supplied by our site. Hope this information will be useful for your research of RARA.
RXRG; RXRA; MED1

RARA Related Articles

Yin, CC; Jain, N; et al. Identification of a Novel Fusion Gene, IRF2BP2-RARA, in Acute Promyelocytic Leukemia. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK 13:19-22(2015).
Mueller, GA; Maleki, SJ; et al. Identification of Maillard reaction products on peanut allergens that influence binding to the receptor for advanced glycation end products. ALLERGY 68:1546-1554(2013).