RARG
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Official Full Name
retinoic acid receptor, gamma
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Overview
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RARG; retinoic acid receptor, gamma; retinoic acid receptor gamma; NR1B3; RARC; Nuclear receptor subfamily 1 group B member 3; RAR gamma; Retinoic acid receptor gamma 1; Retinoic acid receptor gamma 2; Retinoic acid receptor gamma polypeptide; RAR-gamma; OTTHUMP00000045736; OTTHUMP00000241950; OTTHUMP00000241951; OTTHUMP00000241952; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- RARG Related Research Area
RARG involved in several pathways and played different roles in them. We selected most pathways RARG participated on our site, such as Gene Expression, Generic Transcription Pathway, Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | C2orf49;SNAPC5;MED23;ZNF225;GPR19;ELAC2;EHMT2;ZFP37;SKI |
| Generic Transcription Pathway | CDK8;ZNF792;ZNF79;NR2C2AP;NR1D2;TUBB3;ZNF558;NR6A1;ESR2A |
| Nuclear Receptor transcription pathway | NR5A1A;RXRBB;NR0B2A;NR0B1;NR1I2;NR2F1B;NR2F6;NR2C2AP;NRBF2 |
| Nuclear Receptors | NR4A2A;RARGA;NR1I3;NR2F1A;NR1D2B;RARGB;NR2C2;NR0B1;NR1H3 |
| Nuclear receptors in lipid metabolism and toxicity | NR1I2;RARG;RARGB;NR1I3;CYP24A1;ABCC2;RARGA;CYP27B1;VDRB |
| Signal Transduction | CCBP2;SOX13;RARG;RHOUA;SHRPRBCK1R;UTS2D;IRBP;PTPRK;CDC42EP5 |
| Signaling by Retinoic Acid | CRABP2A;CRABP1A;CRABP2;RDH14;PDK3B;ALDH8A1;FABP11A;FABP11B;PDK2B |
| Vitamin A and Carotenoid Metabolism | RARG;CRABP1;RDH10;BCO2;CRABP2;RDH12;DHRS3;RBP7 |
RARG has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RARG itself. We selected most functions RARG had, and list some proteins which have the same functions with RARG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | RUNX2B;NUCB1;NKX2.7;SIX3A;ZNF530;ZFP57;IRX5B;NR4A2A;CERS5 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZNF583;ZFP39;BARHL1A;LMO2;TRP53;GATA4;MNT;ZNF548;ZFP583 |
| protein binding | NLRP2;NITR9;VPS11;ARL6IP1;MXD4;TRAPPC10;EIF2A;DAZL;CNOT10 |
| retinoic acid receptor activity | RARAA;ESRRG;RARAB;RARGB;RXRA;RARG;RARA;RARB;RARGA |
| retinoid X receptor binding | MED25;FUS;NCOR1;HMGA1;RARB;HMGA1-RS1;PPARG;NR4A2;NR1H4 |
| steroid hormone receptor activity | ESR2B;THRAA;PAQR8;NR5A1A;ESRRA;NR0B2;RXRG;NR4A2;PPARDB |
| transcription factor activity, sequence-specific DNA binding | EOMES;ALX1;FOXG1A;ZFP367;ESRRGA;TFE3;FOSL1A;SKINT8;ETV5 |
| zinc ion binding | ZMYM2;LMX1BA;PRICKLE1;RNF145B;EEA1;ANPEP;TADA2A;CSRP1A;MT1X |
RARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RARG here. Most of them are supplied by our site. Hope this information will be useful for your research of RARG.
SORBS3; ZNF423; OIP5; MRPL12; IL24; LSR; RHPN2; ACY3; ZNF576; SPHK1; Sorbs3; MTMR6; FOXC1; myc_human_gene; tff1_human_gene; GREB1; ESR1; RARA
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