rasa4
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  • Official Full Name
  • RAS p21 protein activator 4
  • Background
  • This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • RASA4; RAS p21 protein activator 4; ras GTPase-activating protein 4; CAPRI; GAPL; KIAA0538; Ca2+ promoted Ras inactivator; Calcium promoted Ras inactivator; GTPase activating protein like; MGC131890; Ras GTPase activating protein 4; Ca2+-promoted Ras inactivator; calcium-promoted Ras inactivator; rasGAP-activating-like protein 2
Cat.#:RASA4-13942MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RASA4 Protein
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Cat.#:RASA4-5508CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RASA4
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Cat.#:RASA4-5777ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RASA4
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Involved Pathway

RASA4 involved in several pathways and played different roles in them. We selected most pathways RASA4 participated on our site, such as Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
KLK1B4; PLA2G4D; PDGFRB; RALGDS; NFKB1; RASA1; RAC3; MAPK10; ARF6; RIN1

Protein Function

RASA4 has several biochemical functions, for example, GTPase activator activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASA4 itself. We selected most functions RASA4 had, and list some proteins which have the same functions with RASA4. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein ERRFI1; CDC42EP2; RABGAP1; SRGAP2A; RASAL1; ARHGDIB; TBC1D8; STXBP5L; AGFG1B; RALGAPA1
Function metal ion binding
Related Protein NRXN3B; ZDHHC24; ISL1L; ZFYVE27; IMPDH1B; FUZ; CYP2C54; EXT1B; NAIP1; VAV1