RASGRP1
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Official Full Name
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
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Overview
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008] -
Synonyms
RASGRP1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII; RAS guanyl-releasing protein 1; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; calcium and DAG-regulated guanine nucleotide exchange factor II; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
RASGRP1 involved in several pathways and played different roles in them. We selected most pathways RASGRP1 participated on our site, such as ARMS-mediated activation, Activation of RAS in B cells, Adaptive Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ARMS-mediated activation | MARK3;PEA15A;FGF8B;CSF2RA;SPNA2;PEBP1;FGFR1B;DLG4;NRG3 |
| Activation of RAS in B cells | |
| Adaptive Immune System | Mill2;RNF25;ASB11;FGF8B;CD160;DCTN1;SEC61B;LAIR2;ASB6 |
| Axon guidance | COL9A1B;PAK2;SPNA2;NRP1A;PAQR3B;EPHA8;GNAI3;HBEGF;CSNK2A2 |
| Cytokine Signaling in Immune system | TAB1;IL1RN;FRS3;FRS2;HAVCR2;PELI3;PAQR3B;EGR1;USP18 |
| DAP12 interactions | SPTBN1;RASGRP4;SPRED2;DUSP5;KIR2DS2;RASGRP1;CNKSR1;THEM4;DUSP2 |
| DAP12 signaling | PTPRA;FGF8B;CNKSR1;SPRED3;PRKAR1AA;FRS2;PAQR3B;NEFLB;NRG4 |
| Developmental Biology | CCNC;ITGB1B.1;EFNA1B;KLB;EFNA1A;DUSP9;CNTN1;SCN3A;COL4A4 |
RASGRP1 has several biochemical functions, for example, Ras guanyl-nucleotide exchange factor activity, calcium ion binding, diacylglycerol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP1 itself. We selected most functions RASGRP1 had, and list some proteins which have the same functions with RASGRP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ras guanyl-nucleotide exchange factor activity | RASGRP3;RASGEF1BB;RASGRP1;RASGEF1A;ADRB1;RASGEF1B;RAPGEF5;RASGEF1BA;SOS1 |
| calcium ion binding | SLC24A4A;SCUBE1;MMP30;SYT5A;RCN1;S100A5;PKD2L1;CALM2;CDH23 |
| diacylglycerol binding | RASGRP1;TRPC2;UNC13B;CDIPT;UNC13C;RASGRP4;RASGRP3;RASGRP2;UNC13A |
| guanyl-nucleotide exchange factor activity | PTGIR;RIC8B;FGD4;RASGRP1;DOCK5;ITSN2A;ARHGEF4;ARHGEF3L;RIC8 |
| lipid binding | PACSIN1B;S1PR2;TRIP10A;CRABP2A;MELK;RBP7B;FABP7A;LIPF;BPIFB6 |
| phosphatidylcholine binding | PCTP;APOA1;GPR119;APOA4B.2;CHMP2A;APOC1;APOA5;ALDOB;ESYT2 |
| phosphatidylserine binding | SCARB1;CPNE6;GAP43;TRIM72;OSBPL5;SDPR;PLCD1;THBS1;FCHO2 |
| protein homodimerization activity | TERT;CCDC103;DHDPSL;GIPC1;HOGA1;CCDC88A;ABCG1;SLC4A1;CECR1 |
| zinc ion binding | MMP13;BAZ1A;PRICKLE2A;ZDHHC6;TP53;ADAM15;UBR2;Car12;ZRANB2 |
RASGRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP1.
Dlg4; PPM1B; VHL
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