rasgrp3
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  • Official Full Name
  • RAS guanyl releasing protein 3 (calcium and DAG-regulated)
  • Background
  • Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated;switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),;such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and;are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).
  • Synonyms
  • RASGRP3; RAS guanyl releasing protein 3 (calcium and DAG-regulated); ras guanyl-releasing protein 3; GRP3; KIAA0846; guanine nucleotide exchange factor for Rap1; calcium and DAG-regulated guanine nucleotide exchange factor III
Cat.#:RASGRP3-2190HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RASGRP3, GST-tagged
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Cat.#:RASGRP3-405HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RASGRP3 Protein, GST/His-tagged
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Cat.#:RASGRP3-3794RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RASGRP3 Protein, His-tagged
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Cat.#:RASGRP3-1543CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RASGRP3
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Cat.#:RASGRP3-6184ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RASGRP3
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Cat.#:RASGRP3-2504HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RASGRP3 293 Cell Lysate
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Involved Pathway

RASGRP3 involved in several pathways and played different roles in them. We selected most pathways RASGRP3 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
IL1R2; STMN1; CACNB4; PPM1BA; MAPK9; PRKACA; TP53; PPP3R1; PPP3CB; CACNB3
Ras signaling pathway
SOS1; KSR2; RGL2; KIT; PLA2G2F; FGF2; PDGFRB; PIK3CG; PAK6; PIK3R1
Rap signaling pathway
PARD3; PLCE1; PARD6B; VAV2; VEGFC; FGF3; PRKD1; FGF13; FYB; MAPK3
B cell receptor signaling pathway
PPP3R2; DAPP1; PDK2B; PLEKHA2; CD79A; CD72; VAV2; PPP3R1; PIK3R2; CD22
Pathways in cancer
LAMA4; TRAF6; FGF19; XIAP; LPAR2; IL-8; LAMB2; PDGFA; GNG11; RB1

Protein Function

RASGRP3 has several biochemical functions, for example, GTPase activator activity, Ras GTPase binding, Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP3 itself. We selected most functions RASGRP3 had, and list some proteins which have the same functions with RASGRP3. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein DEPDC1A; RGS9A; TBC1D9; ARHGDIA; DAB2IPB; TBC1D2B; ARRB1; TBCD; ARHGAP9; TBC1D13
Function Ras GTPase binding
Related Protein RIN1; SPHK2; MLLT4; RAPGEF6; MAPKAP1; RASGRP3; SH3BP4; RGL3; RAP1A; CIB1
Function Ras guanyl-nucleotide exchange factor activity
Related Protein RAB3A; SOS1; RASGEF1B; RGL2; RASGEF1BB; RAPGEF4; RAPGEF5; RASGRP1; RASGRP4; RASGEF1BA
Function calcium ion binding
Related Protein PADI1; PCDH1G26; CALN1; LTBP2; PCDHB15; DOC2D; LALBA; MAN1C1; AMY2A; MMP14B
Function diacylglycerol binding
Related Protein RASGRP2; CDIPT; RASGRP1; TRPC2; RASGRP3; RASGRP4; UNC13B; UNC13A; UNC13C
Function guanyl-nucleotide exchange factor activity
Related Protein ARHGEF1B; ARHGEF17; DOCK6; TBXAS1; NET1; KALRN; GDPGP1; ARHGEF18; RALGPS2; SERGEF
Function kinase binding
Related Protein PER1; JAKMIP3; DGKQ; TENC1; C2orf44; CEBPA; RPS3; CHP; PRKAA1; HAP1
Function protein binding
Related Protein HNRNPF; PEX6; SMC2; KPNA6; AP1G1; THOC7; INCA1; C14orf135; IFT172; DDX31
Function signal transducer activity
Related Protein TAAR12E; FAS; ZP3; OLFR147; GNB3; YARS; PLCB4; RERG; HTR1AA; PLCB3

Interacting Protein

RASGRP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP3.
DYNLL2; YWHAQ; SULT1C2; uxuA