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RASGRP4

Official Full Name

RAS guanyl releasing protein 4
Overview

The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

RASGRP4; RAS guanyl releasing protein 4; RAS guanyl-releasing protein 4; guanyl nucleotide releasing protein 4;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RASGRP4-2191H	Recombinant Human RASGRP4, GST-tagged	E.coli	GST	1-168aa	$319 / 25ug
Human	RASGRP4-1477HCL	Recombinant Human RASGRP4 cell lysate		N/A		Inquiry
Mouse	RASGRP4-13955M	Recombinant Mouse RASGRP4 Protein	Mammalian Cell	His		Inquiry
Mouse	RASGRP4-7439M-B	Recombinant Mouse RASGRP4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	RASGRP4-7439M	Recombinant Mouse RASGRP4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	RASGRP4-4938R	Recombinant Rat RASGRP4 Protein	Mammalian Cell	His		Inquiry
Rat	RASGRP4-4597R	Recombinant Rat RASGRP4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	RASGRP4-4597R-B	Recombinant Rat RASGRP4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	RASGRP4-3983Z	Recombinant Zebrafish RASGRP4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

RASGRP4 involved in several pathways and played different roles in them. We selected most pathways RASGRP4 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ARMS-mediated activation	PEBP1;PAQR3A;SPNA2;DAB2IPB;HBEGF;FGFR1B;PSMD5;SPTA1;PSMA8
Axon guidance	ABLIM3;DCX;SPTA1;SRGAP3;RGMB;SRGAP1;CSF2;RND1;RGS3
Cytokine Signaling in Immune system	TRIM17;LGALS9;FGF20A;SPNA1;PAQR3B;OSTN;GHRB;EDA;DUSP6
DAP12 interactions	SPRED2;PAQR3B;KLB;FRS3;AGO2;FRS2A;DUSP2;CD300LB;GRAP2A
DAP12 signaling	SPTA1;LCP2A;JAK3;PTPRA;CSF2RA;MOV10;FGF20A;NRG4;DUSP10
Developmental Biology	RHOGA;NR2F2;PAQR3A;MEF2B;CAP1;SPTBN2;COL9A1A;DUSP5;EZRA
Downstream signal transduction	SPTB;CRKL;DUSP9;PEA15;SPNA1;SPTA1;AGO2;FGF20A;AGO3
Downstream signaling of activated FGFR1	MARK3;SPRED3;AGO2;CNKSR1;SPNA1;SPTB;SPRED2;PAQR3A;RASGEF1A

RASGRP4 has several biochemical functions, for example, GTP-dependent protein binding, Ras guanyl-nucleotide exchange factor activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP4 itself. We selected most functions RASGRP4 had, and list some proteins which have the same functions with RASGRP4. You can find most of the proteins on our site.

Function	Related Protein
GTP-dependent protein binding	RAPGEF5;GCHFR;PPIAL4A;EEA1;MRAS;RAB32;RAB38;CDC42;RASGRP4
Ras guanyl-nucleotide exchange factor activity	RAPGEF5;RASGRP1;RASGEF1A;RASGEF1B;RASGEF1BA;RASGRP3;RASGEF1BB;SOS1;RGL2
calcium ion binding	CELSR2;RAB11FIP3;MMP28;ANXA1C;S100A10;MAN1A2;DSC2;CRB1;SLC25A24L
diacylglycerol binding	RASGRP3;UNC13A;RASGRP1;CDIPT;TRPC2;RASGRP2;UNC13C;RASGRP4;UNC13B

RASGRP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP4.

RAP1A