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RBBP5

Official Full Name

retinoblastoma binding protein 5
Overview

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]
Synonyms

RBBP5; retinoblastoma binding protein 5; RBQ3; SWD1; retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3; SWD1, Set1c WD40 repeat protein, homolog;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E. coli
E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A
SUMO

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RBBP5-025H	Active Recombinant Human RBBP5 Protein, SUMO-tagged	E.coli	SUMO	2-538	Inquiry
Human	RBBP5-082H	Active Recombinant Human RBBP5 Protein	E. coli			Inquiry
Human	RBBP5-2199H	Recombinant Human RBBP5, GST-tagged	E.coli	GST	N-term-327aa	$319 / 25ug
Human	RBBP5-28182TH	Recombinant Human RBBP5, His-tagged	E.coli	His		Inquiry
Human	RBBP5-1479HCL	Recombinant Human RBBP5 cell lysate		N/A		Inquiry
Mouse	RBBP5-13977M	Recombinant Mouse RBBP5 Protein	Mammalian Cell	His		Inquiry
Mouse	RBBP5-7458M	Recombinant Mouse RBBP5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	RBBP5-7458M-B	Recombinant Mouse RBBP5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	RBBP5-10585Z	Recombinant Zebrafish RBBP5	Mammalian Cell	His		Inquiry
Chicken	RBBP5-2603C	Recombinant Chicken RBBP5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

RBBP5 involved in several pathways and played different roles in them. We selected most pathways RBBP5 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Deactivation of the beta-catenin transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBBP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	SAP18;PHF2;CHD4;KAT7A;SMARCB1;MSL3;PRMT5;KAT6A;ELP3
Chromatin organization	DMAP1;KDM4C;CHD4;ELP2;ANO9A;WDR77;ATF7IP;KDM5BB;PBRM1L
Deactivation of the beta-catenin transactivating complex	CBY1;SOX9A;SOX13;PYGO1;SOX6;TLE3;SOX4A;SOX7;C
Formation of the beta-catenin:TCF transactivating complex	CDC73;PYGO2;ASH2L;TLE4;TLE3B;BCL9;PYGO1;H3F3D;TLE3
PKMTs methylate histone lysines	SMYD3;EED;PRDM16;SMYD2;EHMT2;RBBP5;SUZ12B;SETD3;SUZ12
Signal Transduction	NF2A;APLN;APLNR;LEO1;ABR;CHRDL1;SOX4A;USP9;GPR37B
Signaling by Wnt	RBBP5;AES;KREMEN1;CCDC88C;LGR4;KREMEN2;HECW1B;SRY;TLE3B
TCF dependent signaling in response to WNT	HECW1B;RSPO1;RBBP5;KREMEN1;SOX7;WIF1;BCL9L;RSPO4;LGR6

RBBP5 has several biochemical functions, for example, contributes_to histone methyltransferase activity (H3-K4 specific), methylated histone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBBP5 itself. We selected most functions RBBP5 had, and list some proteins which have the same functions with RBBP5. You can find most of the proteins on our site.

Function	Related Protein
contributes_to histone methyltransferase activity (H3-K4 specific)	DPY30;CXXC1;RBBP5;DYDC2;DYDC1;ASH2L
methylated histone binding	L3MBTL1;ATRX;CCDC101;ING2;TDRD3;CBX4;PHF8;PHF19;PHF2
protein binding	BBS9;TMSB4X;CD300A;BICD1;DHDDS;CDA;YWHAG;MKL1;RAB18
transcription regulatory region DNA binding	TAF7;CBX4;TFAP2A;NKX3;KDM1A;TA;TP63;FOXC1;RFX6

RBBP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBBP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBBP5.

ASH2L; KMT2A