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RBBP8

  • Official Full Name

    retinoblastoma binding protein 8

  • Overview

    The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
  • Synonyms

    RBBP8; retinoblastoma binding protein 8; RIM; COM1; CTIP; JWDS; SAE2; SCKL2; DNA endonuclease RBBP8; RBBP-8; CTBP-interacting protein; sporulation in the absence of SPO11 protein 2 homolog;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RBBP8-2201H Recombinant Human RBBP8, GST-tagged E.coli GST C-term-299aa
Human RBBP8-6835HF Recombinant Full Length Human RBBP8 Protein, GST-tagged In Vitro Cell Free System GST 897 amino acids
Human RBBP8-2202H Recombinant Human RBBP8 Protein, GST-tagged Wheat Germ GST
Mouse RBBP8-13979M Recombinant Mouse RBBP8 Protein Mammalian Cell His
Mouse RBBP8-7460M Recombinant Mouse RBBP8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RBBP8-7460M-B Recombinant Mouse RBBP8 Protein Pre-coupled Magnetic Beads HEK293
Rat RBBP8-4951R Recombinant Rat RBBP8 Protein Mammalian Cell His
Rat RBBP8-4610R Recombinant Rat RBBP8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RBBP8-4610R-B Recombinant Rat RBBP8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RBBP8-3805R Recombinant Rhesus monkey RBBP8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RBBP8-3622R Recombinant Rhesus Macaque RBBP8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RBBP8-3622R-B Recombinant Rhesus Macaque RBBP8 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish RBBP8-2058Z Recombinant Zebrafish RBBP8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RBBP8 Related Articles

RBBP8 involved in several pathways and played different roles in them. We selected most pathways RBBP8 participated on our site, such as BARD1 signaling events, Cell Cycle, DNA Double-Strand Break Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBBP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
BARD1 signaling eventsNPM1;RBBP8;RAD50;CSTF1;CDK2;BARD1
Cell CyclePLK1;GSK3B;CENPA;DBF4;MCM7;YWHAQ;RAD9B;CDKN2A;KIF18A
DNA Double-Strand Break RepairRAD50;BARD1;EYA2;BRE;RBBP8;TIPIN;CLSPN;PPP4R2B;UIMC1
DNA RepairTP53BP1;RTEL1;PARP2;FUZ;DCLRE1A;ACTL6A;USP10;DTL;RHNO1
E2F transcription factor networkSMARCA2;CES1;YY1;UXT;DHFR;RYBP;CDKN2C;HIC1;RBBP8
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)PPP4R2;UIMC1;FAM175A;PPP4CA;EME1;RTEL1;TIPIN;RNF168;PPP4R2A
HDR through Homologous Recombination (HRR)TOPBP1;KIAA0146;RAD9;FUZ;RHNO1;EME2;RBBP8;WRN;RAD9B
HDR through MMEJ (alt-NHEJ)

RBBP8 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, RNA polymerase II transcription corepressor activity, damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBBP8 itself. We selected most functions RBBP8 had, and list some proteins which have the same functions with RBBP8. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II repressing transcription factor bindingHDAC1;MKKS;TBP;DMAP1;BBS7;MTA1;GTF2A2;HDAC2;BBS4
RNA polymerase II transcription corepressor activityHDAC1;NFIB;RBBP8;SIN3A;BEND6;TBX18;CITED2;SIN3B;TCERG1
damaged DNA bindingRAD23B;TP63;RBBP8;NEIL2;GTF2H3;XPA;HMGB1;TRP53;APTX
protein bindingBHLHE40;HIST1H2AK;UBD;PRPS2;ACPL2;GATC;AQP1;GPR177;GNB2L1
single-stranded DNA endodeoxyribonuclease activityERCC4;SETMAR;DCLRE1C;MRE11A;RBBP8

RBBP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBBP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBBP8.

BRCA1; CTBP1; EXO1; RBL2; AATF

Fresu, M; Bianchi, M; et al. Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase. BIOCHEMICAL JOURNAL 358:407-414(2001).
Kim, HS; Hausman, GJ; et al. The expression of cyclin D1 during adipogenesis in pig primary stromal-vascular cultures. OBESITY RESEARCH 9:572-578(2001).
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