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RBL1

Official Full Name

retinoblastoma-like 1 (p107)
Overview

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

RBL1; retinoblastoma-like 1 (p107); retinoblastoma-like protein 1; cp107; p107; PRB1; cellular protein 107; 107 kDa retinoblastoma-associated protein; MGC40006;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RBL1-2204H	Recombinant Human RBL1, GST-tagged	E.coli	GST	1-351aa	$319 / 25ug
Human	RBL1-2484HCL	Recombinant Human RBL1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RBL1-067H	Recombinant Human RBL1 Protein	E.coli		1068	Inquiry
Zebrafish	RBL1-7092Z	Recombinant Zebrafish RBL1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RBL1 Related Research Area

RBL1 involved in several pathways and played different roles in them. We selected most pathways RBL1 participated on our site, such as Cell cycle, TGF-beta signaling pathway, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell cycle	NEDD1;SMAD3B;DIDO1;ORC2L;PDS5B;THRSP;OFD1;NSL1;CCNA2
TGF-beta signaling pathway	BMPR2B;ACVR1B;RHOAB;AMHR2;SMAD7B;RHOAD;BAMBIB;TGFB1;ACVR2AA
Viral carcinogenesis	YWHAE;GTF2H1;HIST2H4A;HIST1H4I;PIK3CG;HLA-B;HDAC9;EP300;KRAS

RBL1 has several biochemical functions, for example, protein binding, transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBL1 itself. We selected most functions RBL1 had, and list some proteins which have the same functions with RBL1. You can find most of the proteins on our site.

Function	Related Protein
protein binding	TBX1;SIRT6;NAT2;ARHGAP44;RBP4;PRKD3;SPHK2;CAB39;SH3YL1
transcription factor binding	BCL2;HMGB1;ZBTB49;DIP2C;ID1;REST;IRF4;NR0B2A;DDX3X

RBL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBL1.

CDK2; E7; DHX30; e1a_ade05; DYRK1A; DYRK1B; E7

CKIs(Cyclin Dependent Kinase Inhibitors)