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RBL2

Official Full Name

retinoblastoma-like 2 (p130)
Overview

p130 is a tumor suppressor of the pocket protein family whose expression is posttranscriptionally regulated and largely G0 restricted. The mechanism of down-regulation of p130 expression in proliferating cells was investigated and results indicate that the decline of p130 expression as G0 cells reenter the cell cycle is due to a decrease in protein stability. In vitro polyubiquitination of p130 by SCF(Skp2) was specifically dependent on phosphorylation of p130 on Serine 672 (1). The retinoblastoma family of proteins including pRB, p107 and p130 undergoes cell cycle dependent phosphorylation during the mid-G1 to S phase transition. This phosphorylation is dependent upon the activity of cyclin D/cdk4. In contrast to pRB and p107, p130 is phosphorylated during G0 and the early G1 phase of the cell cycle. Also it is thought that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. Data indicates complementary roles for the Rb/E2F pathway in the control of telomere length (3).
Synonyms

RBL2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; p130; Rb2; PRB2; RBR-2; retinoblastoma-related protein 2; 130 kDa retinoblastoma-associated protein; FLJ26459;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
Mamanlian cells
Mammalian Cell

Tag

Flag
GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RBL2-2205H	Recombinant Human RBL2, GST-tagged	E.coli	GST	N-term-350aa	$319 / 25ug
Human	RBL2-2483H	Recombinant Human RBL2 protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	RBL2-2483HCL	Recombinant Human RBL2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RBL2-6051HFL	Recombinant Full Length Human RBL2 protein, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	RBL2-881H	Recombinant Human RBL2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	RBL2-4358H	Recombinant Human RBL2 protein, His-tagged	E.coli	His	417-616aa	Inquiry
Mouse	Rbl2-5409M	Recombinant Mouse Rbl2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	RBL2-4955R	Recombinant Rat RBL2 Protein	Mammalian Cell	His		Inquiry
Rat	RBL2-4614R-B	Recombinant Rat RBL2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	RBL2-4614R	Recombinant Rat RBL2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	RBL2-2984C	Recombinant Chicken RBL2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RBL2 Related Research Area

RBL2 involved in several pathways and played different roles in them. We selected most pathways RBL2 participated on our site, such as FoxO signaling pathway, Cell cycle, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
FoxO signaling pathway	MAPK13;GABARAPL1;G6PC2;INSRB;PRMT1;PLK4;FOXO4;MAPK14B;CDKN1BA
Cell cycle	CSNK2B;TBC1D8;CKS1B;RUVBL2;CCNB3;ORC6;SMAD4;THRSP;SKP1
PIK-Akt signaling pathway	VTN;PDGFA;IL2RA;GH2;KIT;TNXB;AKT1;GNG10;FGF18
Viral carcinogenesis	HIST1H4I;HRAS;YWHAH;HDAC9;SYK;HDAC11;HIST2H4;HIST1H2BL;PKM

RBL2 has several biochemical functions, for example, DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBL2 itself. We selected most functions RBL2 had, and list some proteins which have the same functions with RBL2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZFP423;VOX;KCNH7;STAT3;HLF;SSH2B;ATXN1L;SOX1;AHCTF1
protein binding	IL17F;CDCA7L;DIAPH1;EFEMP1;DNAJB11;HTR1E;KIAA0408;CCDC6;RALY

RBL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBL2.

CDK2; E2F4; LIN54

CKIs(Cyclin Dependent Kinase Inhibitors)