rbp3
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  • Official Full Name
  • retinol binding protein 3, interstitial
  • Background
  • Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.
  • Synonyms
  • RBP3; retinol binding protein 3, interstitial; retinol-binding protein 3; D10S64; D10S65; D10S66; Interphotoreceptor retinoid binding protein; Interphotoreceptor retinoid-binding protein; Interstitial retinol binding protein; Interstitial retinol-binding protein; IRBP; RBP 3; RBPI; RET3_HUMAN; Retinol binding protein 3; Retinol binding protein 3 interstitial; OTTHUMP00000019536
Cat.#:RBP3-35HTag:His
Source (Host):Human CellsSpecies:Human
Product nameRecombinant Human RBP3 Protein, His-tagged
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Cat.#:RBP3-1501BTag:His
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine RBP3 Protein (633-1231 aa), His-tagged
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Cat.#:RBP3-715HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RBP3 Protein, MYC/DDK-tagged
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Cat.#:RBP3-30611THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RBP3
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Cat.#:RBP3-511HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RBP3 Protein, His-tagged
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Cat.#:Rbp3-512MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rbp3 Protein, His-tagged
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Cat.#:Rbp3-513MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rbp3 Protein, His-tagged
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Cat.#:Rbp3-514RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Rbp3 Protein, His-tagged
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Cat.#:Rbp3-515RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Rbp3 Protein, His-tagged
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Cat.#:RBP3-2181CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RBP3
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Involved Pathway

RBP3 involved in several pathways and played different roles in them. We selected most pathways RBP3 participated on our site, such as Signal Transduction, The canonical retinoid cycle in rods (twilight vision), The retinoid cycle in cones (daylight vision), which may be useful for your reference. Also, other proteins which involved in the same pathway with RBP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signal Transduction
OR10A5; JUPA; CRABP1; NPFF; PENKB; BCL9L; PTPRUB; SST1.1; OXGR1A.1; NPB
The canonical retinoid cycle in rods (twilight vision)
RDH12; RLBP1B; STRA6; RPE65B; RLBP1A; ABCA4A; RBP3; MYO7AA; RPE65A; RLBP1
The retinoid cycle in cones (daylight vision)
IRBP; DHRS3A; RLBP1A; RBP3; DHRS3; OPN1LW2; RLBP1B; RLBP1; OPN1SW1; OPN1LW1
Visual phototransduction
BCO2; RLN1; BCO2L; RPE65B; METAP2B; DHRS9; BCO2A; IRBP; STRA6; GUCA1E
the visual cycle I (vertebrates)
DHRS4; RBP5; RBP3

Protein Function

RBP3 has several biochemical functions, for example, retinal binding, retinoid binding, retinol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBP3 itself. We selected most functions RBP3 had, and list some proteins which have the same functions with RBP3. You can find most of the proteins on our site.
Function
Related Protein
Function retinal binding
Related Protein RBP1; RBP3; RBP7; CRABP2; CRABP1; RBP4; RBP2A; RBP2B; RBP2; RBP5
Function retinoid binding
Related Protein CRABP2; RBP4L; LCN5; CRABP1; RBP5; RBP2; RBP3; PTGDS; RBP1
Function retinol binding
Related Protein RLBP1; ADH7; LRAT; RBP5; RBP1; RBP4; RBP2; CRABP2; RBP3; CRABP1
Function serine-type peptidase activity
Related Protein MCPT2; PRSS59.1; Acr; KLK1B24; Prss32; HGFA; ELA3L; KLK5; GZMF; DPP10