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RBPJ

  • Official Full Name

    recombination signal binding protein for immunoglobulin kappa J region

  • Overview

    The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
  • Synonyms

    RBPJ; recombination signal binding protein for immunoglobulin kappa J region; SUH; csl; AOS3; CBF1; KBF2; RBP-J; RBPJK; IGKJRB; RBPSUH; IGKJRB1; recombining binding protein suppressor of hairless; CBF-1; RBP-JK; RBP-J kappa; H-2K binding factor-2; suppressor of hairless homolog; renal carcinoma antigen NY-REN-30; immunoglobulin kappa J region recombination signal binding protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RBPJ-13H Recombinant Human RBPJ protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RBPJ-31301TH Recombinant Human RBPJ, His-tagged E.coli His
Human RBPJ-2225H Recombinant Human RBPJ, GST-tagged E.coli GST 138-486aa
Human RBPJ-12H Recombinant Human RBPJ protein, His-tagged E.coli His
Human RBPJ-14H Recombinant Human RBPJ protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RBPJ-2453HCL Recombinant Human RBPJ 293 Cell Lysate HEK293 N/A
Human RBPJ-2454HCL Recombinant Human RBPJ 293 Cell Lysate HEK293 N/A
Human RBPJ-1139H Recombinant Human RBPJ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RBPJ-1960HFL Recombinant Full Length Human RBPJ Protein, N-His-tagged E.coli His
Human RBPJ-5292H Recombinant Human RBPJ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RBPJ-2829H Recombinant Human RBPJ protein(91-170 aa), C-His-tagged E. coli C-His 91-170 aa
Mouse Rbpj-5429M Recombinant Mouse Rbpj Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque RBPJ-3828R Recombinant Rhesus monkey RBPJ Protein, His-tagged Mammalian Cell His
Rhesus Macaque RBPJ-3645R Recombinant Rhesus Macaque RBPJ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RBPJ-3645R-B Recombinant Rhesus Macaque RBPJ Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RBPJ Related Articles
  • RBPJ Related Research Area
  • RBPJ Related Signal Pathway

RBPJ involved in several pathways and played different roles in them. We selected most pathways RBPJ participated on our site, such as Notch signaling pathway, Epstein-Barr virus infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBPJ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Notch signaling pathwayDLL3;NOTCH1;DVL3A;MAML2;RBPJB;PSEN2;CTBP2;RBPJL;KAT2B
Epstein-Barr virus infectionCR2;RB1;HLA-DRB1;YWHAG;MAPK11;PSMC5;PTMA;POLR2J;RELA
Viral carcinogenesisMDM2;HDAC3;HIST1H2BG;HIST1H4J;SNW1;CCNE2;CCNA2;MRPS18B;CASP8

RBPJ has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBPJ itself. We selected most functions RBPJ had, and list some proteins which have the same functions with RBPJ. You can find most of the proteins on our site.

Function Related Protein
DNA bindingTP53;SIX4;ZNF358;ZNF410;EGR2B;HIST1H2BP;DMRT2B;ZBTB39;Ar
RNA polymerase II core promoter proximal region sequence-specific DNA bindingZNF562;MYOD1;GLI2;PATZ1;T;HOXA7;RBPJ;Ar;TBX3
RNA polymerase II core promoter sequence-specific DNA bindingH2AFZ;TFAP2B;SP3;SOX8;SFPI1;EGR1;SUZ12;STAT5A;SOX11
RNA polymerase II repressing transcription factor bindingGTF2A2;GSC;SIN3A;HDAC2;RBPJ;MTA2;MIXL1;HDAC1;CHD4
chromatin bindingBAZ1B;HMG20A;EYA3;ANKRD2;MSH6;JARID2;MEF2C;ANKRD17;NR5A1
protein N-terminus bindingPPP1CC;RND2;ARF6;CHMP6;TRAF6;UNC13A;EXOC4;SYNGR3;SERPINB1A
protein bindingSENP6;MYO6;TXNIP;RNPS1;FAM20C;ERH;Trf;EPHA7;AICDA
recombinase activityRAD51C;RAD51L1;RBPJ;RAD51;RAD51L3;XRCC2;DMC1;RAD51D;XRCC3
sequence-specific DNA bindingPOU4F2;MTA3;HOXC8;NR1D4A;DMRT3;PAX2A;SIX1B;NANOG;ELF2B
transcription factor activity, sequence-specific DNA bindingCREB5;DBPA;HOMEZ;YBX1;HIF1AB;SMAD5;NR1D1;MYCL1;MYCN
transcription factor bindingHES1;CDK9;FLNA;CDKN2A;ARRB1;TLE1;NKX3;TFDP1B;EPAS1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGRHL1;NPAS4;ELK3;NEUROG3;ZFP292;BARHL2;ETV2;DBP;NEUROD6

RBPJ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBPJ here. Most of them are supplied by our site. Hope this information will be useful for your research of RBPJ.

NOTCH1; ATXN1L; ATXN1; RITA1

Guiu, J; Bergen, DJM; et al. Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. JOURNAL OF EXPERIMENTAL MEDICINE 211:2411-2423(2014).
Querol, L; Clark, PL; et al. Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. NEUROLOGY 81:956-963(2013).
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