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RCHY1

  • Official Full Name

    ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase

  • Overview

    RING finger and CHY1 zinc finger domain-containing protein 1 (RCHY1) is a newly identified RING-H2-type protein-ubiquitin E3 ligase that is expressed as multiple isoforms generated through alternative splicing of mRNA transcripts. Notably, RCHY1 is a p53-
  • Synonyms

    RCHY1; ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; ring finger and CHY zinc finger domain containing 1 , zinc finger protein 363 , ZNF363; RING finger and CHY zinc finger domain-containing protein 1; androgen recepto;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RCHY1-233H Recombinant Human ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase, His-tagged E.coli His
Human RCHY1-2444HCL Recombinant Human RCHY1 293 Cell Lysate HEK293 N/A
Human RCHY1-4559H Recombinant Human RCHY1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RCHY1-4646H Recombinant Human RCHY1 protein, GST-tagged E.coli GST 1-261aa
Human RCHY1-234H Recombinant Human RCHY1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse RCHY1-14034M Recombinant Mouse RCHY1 Protein Mammalian Cell His
Mouse Rchy1-5437M Recombinant Mouse Rchy1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse RCHY1-7498M Recombinant Mouse RCHY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RCHY1-7498M-B Recombinant Mouse RCHY1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RCHY1-3833R Recombinant Rhesus monkey RCHY1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RCHY1-3650R-B Recombinant Rhesus Macaque RCHY1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RCHY1-3650R Recombinant Rhesus Macaque RCHY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RCHY1-11879Z Recombinant Zebrafish RCHY1 Mammalian Cell His
Chicken RCHY1-3643C Recombinant Chicken RCHY1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

RCHY1 involved in several pathways and played different roles in them. We selected most pathways RCHY1 participated on our site, such as p signaling pathway, Ubiquitin mediated proteolysis, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCHY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
p signaling pathwaySIAH1;APAF1;PIDD1;CCNB2;SHISA5;CASP3A;MDM4;SERPINB5;FAS
Ubiquitin mediated proteolysisITCHA;UBE2Z;UBE2D2L;HERC2;WWP2;DET1;ANAPC2;UBE2NB;UBE2E3
MeaslesTNFRSF10B;TLR7;GSK3B;TBK1;IFNAR1;Ifna11;MSN;IFNAR2;BBC3

RCHY1 has several biochemical functions, for example, ligase activity, p53 binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCHY1 itself. We selected most functions RCHY1 had, and list some proteins which have the same functions with RCHY1. You can find most of the proteins on our site.

Function Related Protein
ligase activityRNF180;TRAF2;TTLL9;CNOT4;PET112L;MARCH10;MARCH2;MEX3C;RCHY1
p53 bindingAAAS;ZNF385D;SETD7;DUSP26;USP10;GSK3B;SMARCA4;RFFL;AXIN1
protein bindingP4HA3;TDG;BANF1;VAMP5;HEY1;FAM168A;PHF15;ISG15;HIP1
protein homodimerization activityTHRA;PON1;TPR;ALX1;HNF1B;NOS2;PVRL1;CDA;CARD8
receptor bindingAPLN;CRH;SMARCD3;CYTL1;SNX17;CROT;PVRL1A;ZAP70;Icosl
ubiquitin-protein transferase activityRNF182;ANKIB1A;G2E3;UBE2C;MIB2;RNF38;SHPRH;CMTM2A;UBE2H
zinc ion bindingSF3A3;FBXO40.1;PRKCBA;RNF7;ESR2A;GATA1A;ZMAT3;ZDHHC7;MARCH2

RCHY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCHY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCHY1.

TP53; NLK; AIG1; MEOX2; 25796

  • Q&As
  • Reviews

Q&As (6)

Ask a question
Why RCHY1 attempts to provide supportive information as a marker in early node-negative oral squamous cell carcinoma? 11/04/2020

RCHY1 acts as an independent target in early-stage node-negative oral squamous cell carcinoma and may provide patients with more accurate diagnostic and prognostic information.

What is the association between RCHY1 and ovarian, breast cancer, etc.? 10/23/2020

The association between RCHY1 and ovarian and breast cancer is mainly manifested in its regulation of hormone receptor expression, migration and invasion.

Is RCHY1 an important driver? 12/13/2019

RCHY1, as a Ubiquitin ligase, has been found as a driving factor in a variety of cancers such as liver, prostate, and kidney cancer.

How about the relationship between the expression of RCHY1 and prognosis? 07/03/2019

RCHY1 is expressed in different types of cancer, and its high expression is associated with poor prognosis and high risk of metastasis.

Does the polymorphism of RCHY1 predict tumor recurrence? 06/03/2019

For breast and ovarian cancer patients, the polymorphisms of RCHY1 are associated with the risk of tumor recurrence and can be used as a biomarker to predict recurrence.

What is the role of RCHY1 in apoptosis? 03/03/2019

RCHY1 is involved in regulating apoptosis signaling pathways by mediating the single ubiquitination pathway and promoting apoptosis of tumor cells.

Customer Reviews (3)

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Reviews
11/25/2019

    Experiments using RCHY1 were very reproducible and allowed me to evaluate the results more accurately.

    07/18/2019

      Due to stability of RCHY1 was still very good under different experimental conditions, indicating that it has a wide range of applications and adaptability.

      04/10/2019

        The band definition of RCHY1 in Western blot was very high, which improved the confidence of the experiment.

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