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RDH12

  • Official Full Name

    retinol dehydrogenase 12 (all-trans/9-cis/11-cis)

  • Overview

    The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and;all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not;exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).
  • Synonyms

    RDH12; retinol dehydrogenase 12 (all-trans/9-cis/11-cis); retinol dehydrogenase 12 (all trans and 9 cis); retinol dehydrogenase 12; FLJ30273; LCA13; SDR7C2; short chain dehydrogenase/reductase family 7C; member 2; All trans and 9 cis retinol dehydrogenase; All-trans and 9-cis retinol dehydrogenase; LCA 3; LCA3; RDH 12; RDH12_HUMAN; Retinol dehydrogenase 12 (all trans/9 cis/11 cis); retinol dehydrogenase 12, all-trans and 9-cis; short chain dehydrogenase/reductase family 7C, member 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RDH12-31307TH Recombinant Human RDH12, His-tagged E.coli His 278 amino acids
Human RDH12-2237H Recombinant Human RDH12, GST-tagged E.coli GST 1-316aa
Human RDH12-1371H Recombinant Human Retinol Dehydrogenase 12 (all-trans/9-cis/11-cis), His-tagged E.coli His
Human RDH12-2437HCL Recombinant Human RDH12 293 Cell Lysate HEK293 N/A
Human RDH12-4692H Recombinant Human RDH12 protein, His-SUMO-tagged E.coli His-SUMO 1-316aa
Mouse RDH12-14047M Recombinant Mouse RDH12 Protein Mammalian Cell His
Mouse RDH12-7508M Recombinant Mouse RDH12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RDH12-7508M-B Recombinant Mouse RDH12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RDH12-3838R Recombinant Rhesus monkey RDH12 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RDH12-3655R-B Recombinant Rhesus Macaque RDH12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RDH12-3655R Recombinant Rhesus Macaque RDH12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RDH12-474Z Recombinant Zebrafish RDH12 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RDH12 Related Articles

RDH12 involved in several pathways and played different roles in them. We selected most pathways RDH12 participated on our site, such as Metabolic pathways, Retinol metabolism, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RDH12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysACOT8;LYCAT;HLCS;MRI1;DCTPP1;GPAA1;AUH;POLR2GL;PIGX
Retinol metabolismLRATA;RDH10B;RDH5;RDH8B;CYP3A25;ALDH1A1;ADH2-1;DHRS4;RETSATL
Signal TransductionDACT1;ARHGAP23;RGS4;RNF31;ARHGEF16;SST1.1;ZFPM2B;GPRC6A;SKILB
The canonical retinoid cycle in rods (twilight vision)IRBP;SDR9C7;MYO7A;ABCA4A;RLBP1B;STRA6;RDH10;RPE65B;RDH12
Visual phototransductionSTRA6;RLBP1A;RLBP1B;APOA4A;BCO2;GRK7;RGS9BP;MYO7A;RDH12
Visual signal transduction: ConesRLN1;ARR3;GRK7;CNGA3;RDH12
Visual signal transduction: RodsRDH12;CNGA1
Vitamin A and Carotenoid MetabolismRDH12;CRABP1;RARG;BCO2;RBP7;CRABP2;DHRS3;RDH10

RDH12 has several biochemical functions, for example, protein binding, retinol dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RDH12 itself. We selected most functions RDH12 had, and list some proteins which have the same functions with RDH12. You can find most of the proteins on our site.

Function Related Protein
protein bindingFBXL8;CNOT1;ALOX12B;F2R;NEK3;CDK2AP1;MRPS27;CRYBA4;APTX
retinol dehydrogenase activityBMP2;HSD17B6;ADH7;RDH1;RDH11;RDH10;RDH12;RDH8;DHRS9

RDH12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RDH12 here. Most of them are supplied by our site. Hope this information will be useful for your research of RDH12.

RBPMS; UBC; BUB1; ANXA8; MAP1LC3A

Yucel-Yilmaz, D; Tarlan, B; et al. Genome-Wide Homozygosity Mapping in Families with Leber Congenital Amaurosis Identifies Mutations in AIPL1 and RDH12 Genes. DNA AND CELL BIOLOGY 33:876-883(2014).
Sanchez-Alcudia, R; Corton, M; et al. Contribution of Mutation Load to the Intrafamilial Genetic Heterogeneity in a Large Cohort of Spanish Retinal Dystrophies Families. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:7562-7571(2014).
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