ret
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  • Official Full Name
  • ret proto-oncogene
  • Background
  • This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
  • Synonyms
  • RET; ret proto-oncogene; PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16; RET-ELE1; proto-oncogene tyrosine-protein kinase receptor Ret; proto-oncogene c-Ret; receptor tyrosine kinase; RET transforming sequence; cadherin family member 12; hydroxyaryl-protein kinase; cadherin-related family member 16; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease);
Cat.#:RET-5475HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Ret Proto-Oncogene, GST-tagged
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Cat.#:RET-5476HTag:GST/His
Source (Host):Sf9 insect cellsSpecies:Human
Product nameRecombinant Human Ret Proto-Oncogene, GST-His-tagged
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Cat.#:RET-716HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human RET Protein, His-tagged
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Cat.#:RET-91HTag:GST-His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human RET Protein, GST-His-tagged
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Cat.#:RET-16HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RET (G691S), GST-tagged
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Cat.#:RET-1850HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Ret Proto-Oncogene, GST-tagged
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Cat.#:RET-290HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RET protein, His-tagged
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Cat.#:RET-291HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RET protein, His-tagged
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Cat.#:RET-292HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RET protein, His-tagged
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Cat.#:RET-293HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RET protein, His-tagged
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Cat.#:RET-34HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RET (R749T), GST-tagged
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Cat.#:RET-35HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RET (E762Q), GST-tagged
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Cat.#:RET-36HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RET (V804M), GST-tagged
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Cat.#:RET-37HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RET (R813Q), GST-tagged
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Cat.#:RET-38HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RET (A883F), GST-tagged
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Cat.#:RET-3948HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RET, His & GST tagged
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Cat.#:RET-417HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Ret Proto-oncogene, GST-tagged, Active
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Cat.#:RET-52HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RET (V778I), GST-tagged
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Cat.#:RET-53HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RET (L790F), GST-tagged
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Cat.#:RET-64HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RET (S891A), GST-tagged
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Cat.#:RET-65HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RET (M918T), GST-tagged
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Cat.#:RET-684HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human RET Protein, DDK/His-tagged
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Cat.#:RET-685HTag:DDK
Source (Host):sf9 cellsSpecies:Human
Product nameRecombinant Human RET Protein, DDK-tagged
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Cat.#:RET-686HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human RET Protein, DDK-tagged
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Cat.#:RET-7010HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human RET, His tagged
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Cat.#:RET-75HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human RET protein, Flag-tagged, Biotinylated
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Cat.#:RET-14085MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RET Protein
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Cat.#:Ret-18MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Ret/FC Chimera
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Cat.#:RET-6744CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RET
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Cat.#:RET-9631ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RET
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Cat.#:RET-1928HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human Ret Proto-oncogene, His-tagged
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Cat.#:Ret-1776MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Ret Proto-oncogene
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Cat.#:RET-1822HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human RET cell lysate
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Cat.#:RET-570HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RET cell lysate
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Involved Pathway

RET involved in several pathways and played different roles in them. We selected most pathways RET participated on our site, such as Endocytosis, Pathways in cancer, Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RET were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
IGF2R; STAMBPB; DAB2; PIP5K1BB; ADRB2B; ITCHA; VPS26A; CHMP2A; RET; CHMP1B
Pathways in cancer
ZBTB16; NFKB1; CBL; SLC2A1; CKS2; CYCS; EGLN2; CASP9; SKP2; TRAF2
Thyroid cancer
TCF7; MAP2K1; MAPK3; CCDC6; RXRG; TPR; TCF7L2; NTRK1; TRP53; TFG
Central carbon metabolism in cancer
FGFR3; MTOR; FLT3; PIK3CD; TP53; NRAS; PFKM; HKDC1; MAP2K2; PGAM1

Protein Function

RET has several biochemical functions, for example, ATP binding, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RET itself. We selected most functions RET had, and list some proteins which have the same functions with RET. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KTI12; PEX6; NTRK2; RIPK2; GLULC; PCXA; KIF5B; P2RX5; CAMK1DB; ACVR1C
Function calcium ion binding
Related Protein NCALD; CLSTN1; PCDH1G1; CDK5R1; SLC24A1; CGREF1; MMP3; SLC25A23B; PCDH2AB6; CALM2
Function protein binding
Related Protein MDFI; IL11; NOX5; P2RY1; PTPRB; IRAK2; PLCG2; ULK2; NUMBL; GCA
Function protein tyrosine kinase activity
Related Protein ERBB3A; TNK2B; DYRK2; IGF1RA; ROS1; FYNA; TNK1; MAP2K5; FES; EPHB2
Function receptor activity
Related Protein CSF2RB; VMN1R44; CD46; NOTCH1B; P2RY1; KLRG1; VMN1R52; GUCY1B3; VMN1R47; PVRL2L
Function transmembrane receptor protein tyrosine kinase activity
Related Protein NTRK2B; ERBB2; FGFR1B; INSRB; EPHB4; EGFRA; KITB; INSRR; EPHB3A; EPHA4B

Interacting Protein

RET has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RET here. Most of them are supplied by our site. Hope this information will be useful for your research of RET.
CBL; Sh2b1; PLCG1; STAT3; NOTCH2NL; Plcg1

RET Related Articles

Gurzu, S; Ciortea, D; et al. The immunohistochemical profile of granular cell (Abrikossoff) tumor suggests an endomesenchymal origin. ARCHIVES OF DERMATOLOGICAL RESEARCH 307:151-157(2015).
Doberstein, K; Harter, PN; et al. Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT. INTERNATIONAL JOURNAL OF CANCER 136:E326-E339(2015).