rfc2
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  • Official Full Name
  • replication factor C (activator 1) 2, 40kDa
  • Background
  • The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms
  • RFC2; replication factor C (activator 1) 2, 40kDa; replication factor C (activator 1) 2 (40kD); replication factor C subunit 2; A1; activator 1; RFC40; A1 40 kDa subunit; RF-C 40 kDa subunit; activator 1 subunit 2; replication factor C 2; activator 1 40 k
Cat.#:RFC2-1703HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RFC2 protein, His & T7-tagged
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Cat.#:Rfc2-1704MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rfc2 protein, His & T7-tagged
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Cat.#:RFC2-5004RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RFC2 Protein
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Cat.#:RFC2-3856RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RFC2 Protein, His-tagged
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Cat.#:RFC2-7078CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RFC2
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Cat.#:RFC2-2119ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RFC2
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Cat.#:RFC2-2412HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RFC2 293 Cell Lysate
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Involved Pathway

RFC2 involved in several pathways and played different roles in them. We selected most pathways RFC2 participated on our site, such as DNA replication, Nucleotide excision repair, Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFC2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA replication
GINS3; PRIM2; MCM5; RFC5; POLA1; PRIM1; MCM3L; MCM6L; RNASEH2B; RFC2
Nucleotide excision repair
RFC4; XPC; ZFP830; ZNF830; POLE; INO80B; COPS3; POLE2; COPS7B; ERCC4
Mismatch repair
RFC2; SSBP1; MLH1; RFC5; POLD2; RFC3; MLH3; POLD1; PMS2; RPA4

Protein Function

RFC2 has several biochemical functions, for example, ATP binding, contributes_to DNA clamp loader activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFC2 itself. We selected most functions RFC2 had, and list some proteins which have the same functions with RFC2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TARS2; MYH8; MYH9A; SMARCA4; MAP4K1; KIAA1804; NEK10; ERBB2; P2RX4A; HARS2
Function contributes_to DNA clamp loader activity
Related Protein RFC5; DSCC1; RFC2; RFC4
Function protein binding
Related Protein IFT172; CD19; HOXC4; MYH10; NUFIP1; GABBR2; ACVR2A; PEX12; RCAN3; NDUFA9

Interacting Protein

RFC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RFC2.
RFC4; RFC1; PRKAR1A; RFC5