rfxank
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  • Official Full Name
  • regulatory factor X-associated ankyrin-containing protein
  • Background
  • Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.
  • Synonyms
  • RFXANK; regulatory factor X-associated ankyrin-containing protein; DNA-binding protein RFXANK; ANKRA1; ankyrin repeat containing regulatory factor X associated protein; BLS; DNA binding protein RFXANK; F14150_1; MGC138628; regulatory factor X subunit B; RFX B; RFX Bdelta4; Ankyrin repeat family A protein 1; Regulatory factor X associated ankyrin containing protein; RFX-B; RFXB; RFXB delta 4; RFXK_HUMAN; RFX-Bdelta4; ankyrin repeat-containing regulatory factor X-associated protein
Cat.#:RFXANK-2266HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RFXANK, His-tagged
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Cat.#:RFXANK-234HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human regulatory factor X-associated ankyrin-containing protein, His-tagged
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Cat.#:RFXANK-3864RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RFXANK Protein, His-tagged
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Cat.#:RFXANK-3040CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RFXANK
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Cat.#:RFXANK-7110ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RFXANK
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Cat.#:RFXANK-2393HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RFXANK 293 Cell Lysate
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Cat.#:RFXANK-2394HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RFXANK 293 Cell Lysate
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Involved Pathway

RFXANK involved in several pathways and played different roles in them. We selected most pathways RFXANK participated on our site, such as Antigen processing and presentation, Tuberculosis, Primary i, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFXANK were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
PDIA3; KIR2DL3; HLA-A; PSME1; HLA-DMA; KLRD1; KIR2DL4; HLA-G; HLA-DRB3; HLA-DPA1
Tuberculosis
CD209; IFNA21; IFNA13; FCGR3; IFNGR2; NOS2; RFX5; IL1A; KSR1; SYK
Primary i
TNFRSF13B; UNG; RFXAP; CD79A; AICDA; AIRE; PTPRC; CD4; CD40LG; RAG2
nodeficiency
ICOS; BTK; IKBKG; RAG1; AICDA; IL2RG; CD19; LCK; CD40; ORAI1

Protein Function

RFXANK has several biochemical functions, for example, DNA binding, histone deacetylase binding, transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RFXANK itself. We selected most functions RFXANK had, and list some proteins which have the same functions with RFXANK. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HOXC13A; SMARCB1A; RARAA; H2AFB1; RIMKLB; HIST2H3C; SP9; POLR3K; MGAA; FOXL2
Function histone deacetylase binding
Related Protein PKN1; DDX20; YY1; TOP2A; MAGEA2B; MECP2; GMNN; YWHAE; XBP1; SKOR2
Function transcription cofactor activity
Related Protein SLC26A3; PHF21A; TRIP13; MED30; MAP3K7; PRKCBP1L; SUPT20H; MXD1; MED13; NRG1
Function transcription factor activity, sequence-specific DNA binding
Related Protein SNAPC4; E2F5; HIF1AL; ZFP639; CBFA2T3; AFF4; ZFP551; IRF3; EOMES; HSF1

Interacting Protein

RFXANK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFXANK here. Most of them are supplied by our site. Hope this information will be useful for your research of RFXANK.
BSG; DDOST; HNRNPM; DCTN1; TBR1; PTCD3; C20orf24; ACTR6; NFKBIL1; PHLDA3