RFXANK
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Official Full Name
regulatory factor X-associated ankyrin-containing protein
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Overview
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity. -
Synonyms
RFXANK; regulatory factor X-associated ankyrin-containing protein; DNA-binding protein RFXANK; ANKRA1; ankyrin repeat containing regulatory factor X associated protein; BLS; DNA binding protein RFXANK; F14150_1; MGC138628; regulatory factor X subunit B; RFX B; RFX Bdelta4; Ankyrin repeat family A protein 1; Regulatory factor X associated ankyrin containing protein; RFX-B; RFXB; RFXB delta 4; RFXK_HUMAN; RFX-Bdelta4; ankyrin repeat-containing regulatory factor X-associated protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
RFXANK involved in several pathways and played different roles in them. We selected most pathways RFXANK participated on our site, such as Antigen processing and presentation, Tuberculosis, Primary i, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFXANK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | KIR2DS5;PSME2;PDIA3;KIR2DS4;RFXANK;CD8A;CANX;HLA-DQA1;HLA-E |
| Tuberculosis | MAPK8;HLA-DRB3;CAMK2A;HLA-DRA;AKT2;IL23;IFNA13;LSP1;MAPK13 |
| Primary i | ICOS;RFXAP;RAG1;CD19;IGLL1;ZAP70;ORAI1;BTK;TAP2 |
| nodeficiency | AIRE;IL7R;IGLL1;CD40;ORAI1;PTPRC;CD3E;Cd79a, Cd79b;RAG1 |
RFXANK has several biochemical functions, for example, DNA binding, histone deacetylase binding, transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RFXANK itself. We selected most functions RFXANK had, and list some proteins which have the same functions with RFXANK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | EBF4;RXRAA;TAF4B;ZFP423;TAF1A;HOMEZ;IRX3A;SAP30;HOXB3A |
| histone deacetylase binding | MEF2B;YWHAB;SKOR2;PRDM1;TRAF6;BRMS1;MAGEA2B;USF1;NR2E1 |
| transcription cofactor activity | NFKBIZ;TFB2M;PHF21A;MED30;MAX;MSX2;ZNF212;SND1;ZMYND11 |
| transcription factor activity, sequence-specific DNA binding | ESR1;POU2F1B;HNF4A;RXRB;NFIX;RXRGA;HIVEP3;ELK4;GLI2 |
RFXANK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFXANK here. Most of them are supplied by our site. Hope this information will be useful for your research of RFXANK.
BSG; DDOST; HNRNPM; DCTN1; TBR1; PTCD3; C20orf24; ACTR6; NFKBIL1; PHLDA3
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