rfxap
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  • Official Full Name
  • regulatory factor X-associated protein
  • Background
  • Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene.
  • Synonyms
  • RFXAP; regulatory factor X-associated protein; Regulatory factor X associated protein; RFX associated protein; RFX DNA binding complex 36 kDa subunit; RFX DNA-binding complex 36 kDa subunit; RFX-associated protein; RFXAP_HUMAN; OTTHUMP00000018260
Cat.#:RFXAP-2267HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RFXAP, GST-tagged
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Cat.#:RFXAP-14121MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RFXAP Protein
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Cat.#:RFXAP-3865RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RFXAP Protein, His-tagged
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Cat.#:RFXAP-1496HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RFXAP cell lysate
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Involved Pathway

RFXAP involved in several pathways and played different roles in them. We selected most pathways RFXAP participated on our site, such as Antigen processing and presentation, Tuberculosis, Primary i, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFXAP were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
HLA-B; KIR2DS3; TAPBP; KIR3DL2; HSP90AA1; RFX5; HLA-DPA1; HLA-F; HLA-DRB4; NFYB
Tuberculosis
ATP6V0C; IL1B; IL12B; AKT2; APAF1; FCGR1; MAPK1; ITGAM; TGFB3; TGFB2
Primary i
BLNK; CD40; PTPRC; BTK; DCLRE1C; CD3D; RAG1; CD19; AIRE; LCK
nodeficiency
DCLRE1C; IL2RG; RFXAP; CD8B1; TNFRSF13B; RAG2; IKBKG; RFXANK; ZAP70; AICDA

Protein Function

RFXAP has several biochemical functions, for example, DNA binding, transcription coactivator activity, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFXAP itself. We selected most functions RFXAP had, and list some proteins which have the same functions with RFXAP. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein DBX1B; HOXC13A; KCNA3; DDX20; FOXO3; ZNF434; OASL; ASCL1A; HOXD13; ZNF512
Function transcription coactivator activity
Related Protein GRIP1; USP22; TAF5L; SUB1B; TADA1; TAF6L; MED17; NR1I3; RAP2C; Ankar
Function transcription factor activity, sequence-specific DNA binding
Related Protein NR6A1B; ZBTB11; PBX1; TGIF2; HOXA4A; ELF3; MYBL2; HMGB2; NR3C2; ATF5

Interacting Protein

RFXAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFXAP here. Most of them are supplied by our site. Hope this information will be useful for your research of RFXAP.
EPS8; RFX5; Rfx5