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RGS14

  • Official Full Name

    regulator of G-protein signaling 14

  • Overview

    This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
  • Synonyms

    RGS14; regulator of G-protein signaling 14; regulator of G protein signalling 14; regulator of G-protein signalling 14;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • No tag
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RGS14 Related Articles

RGS14 involved in several pathways and played different roles in them. We selected most pathways RGS14 participated on our site, such as Calcium Regulation in the Cardiac Cell, G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium Regulation in the Cardiac CellRGS5;KCNB1;GJB1;RGS4;GJB2;RGS17;RGS11;KCNJ5;ANXA6
G alpha (i) signalling eventsCHRM4;PENKA;LPAR5A;GPR55A;OPN1LW;CNR2;OPN1MW;RLN3;NPB
GPCR downstream signalingABR;MLN;ARHGEF3;ARHGEF18;GCGA;SST;DRD2;OPN1LW;GNA13B
Myometrial Relaxation and Contraction PathwaysRGS11;RGS18;RGS5;ADM;CORIN;RGS6;RXFP2;CRHR1;IGFBP4
Rap1 signaling pathwayEFNA4;PFN4;EFNA2;RGS14;CSF1;LOC608458
Signal TransductionPYGO2;USP9;RGS11;ARHGEF18A;FGFBP1;NEDD8L;TAS2R7;PCSK6;OR2AP1
Signaling by GPCROXGR1A.1;ARHGEF18A;RLN2;ADM2;OPN4B;FGD4A;XK;CXCR7B;CCBP2

RGS14 has several biochemical functions, for example, G-protein alpha-subunit binding, GDP-dissociation inhibitor activity, GTPase activating protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS14 itself. We selected most functions RGS14 had, and list some proteins which have the same functions with RGS14. You can find most of the proteins on our site.

Function Related Protein
G-protein alpha-subunit bindingOPRM1;DRD1A;RGS4;RIC8A;CRHR1;HTR2B;RIC8;PPP5C;AGTR1A
GDP-dissociation inhibitor activityGDI1;SH3BP4A;GPSM1B;RANBP1;ITGB1BP1;SH3BP4;RGS14;GPSM1;GPSM2L
GTPase activating protein bindingCDH1;TUBB;PIN1;RGS14;PLCD1;MEX3B;GNAO1;TSC1;GAPVD1
GTPase activator activityTBC1D30;SGSM2;ALDH1A2;RAP1GAP2B;RGS5A;RIC8A;FAM13A;RACGAP1;GIT1
microtubule bindingDPYSL5;CNN3;REEP4;KIFC2;CCDC88A;NEIL2;CEP57;RCC2;MAP1S
protein bindingARL2BP;XK;KRT80;PRPF4B;C8orf48;RAB5C;SNRPC;TOB1A;FAM176B
receptor signaling complex scaffold activityNCK2;SHANK1;MAGI2;CD3E;LRRK2;NCK1;GRIP2A;MMS19;SPAG9
receptor signaling protein activityRGS12B;ARF1;DOK1;NCR1;PDCL;TGFBR1;FLRT2;IL1RL1;SMAD1

RGS14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS14 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS14.

TINF2; GNAI1; GNAI1; XPO1; GNAI3; NFKB1; WAS; TRAF2; POT1

Evans, PR; Lee, SE; et al. Postnatal Developmental Expression of Regulator of G Protein Signaling 14 (RGS14) in the Mouse Brain. JOURNAL OF COMPARATIVE NEUROLOGY 522:186-203(2014).
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